Epigenetic and physiological alterations in zebrafish subjected to hypergravity Article Swipe
Marcela Salazar
,
Sílvia Joly
,
G. Anglada‐Escudé
,
Laia Ribas
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.10.05.560885
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.10.05.560885
Gravity is one of the most constant environmental factors across Earth’s evolution and all organisms are adapted to it. Consequently, spatial exploration has captured the interest in studying the biological changes that physiological alterations are caused by gravity. In the last two decades, epigenetics has explained how the environmental cues are able to altered gene functions in the organisms. Although many studies addressed gravity, the underlying biological and molecular mechanisms that are occurred in altered gravity for those epigenetics-related mechanisms, are mostly inexistent. The present study addressed the effects of hypergravity on development, behavior, gene expression, and most importantly, on the epigenetic changes in a world-wide animal model, the zebrafish ( Danio rerio ). To perform hypergravity experiments, a custom-centrifuge simulating the large diameter centrifuge (100 rpm ∼ 3 g ) were designed and zebrafish embryos were exposed during 5 days post fertilization (dpf). Results showed a significant decrease of survival at 2 dpf but not significance in the hatching rate. Physiological and morphological alterations including fish position, movement frequency and swimming behavior showed significant changes due to hypergravity. Epigenetic studies showed a significant hypermethylation of the genome of the zebrafish larvae subjected to 5 days of hypergravity. A downregulation of the gene expression of three epigenetic-related genes ( dnmt1 , dnmt3 , and tet1 ), although not significant, were further observed. Taken altogether, gravity alterations affected biological responses including epigenetics in fish, providing a valuable roadmap of the putative hazards of living beyond Earth.
Related Topics
Concepts
Hypergravity
Zebrafish
Epigenetics
Danio
Biology
DNA methylation
Gene
Gene expression
Genetics
Astrobiology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.10.05.560885
- https://www.biorxiv.org/content/biorxiv/early/2023/10/06/2023.10.05.560885.full.pdf
- OA Status
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- References
- 101
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1101/2023.10.05.560885Digital Object Identifier
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Epigenetic and physiological alterations in zebrafish subjected to hypergravityWork title
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preprintOpenAlex work type
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enPrimary language
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2023Year of publication
- Publication date
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2023-10-06Full publication date if available
- Authors
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Marcela Salazar, Sílvia Joly, G. Anglada‐Escudé, Laia RibasList of authors in order
- Landing page
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https://doi.org/10.1101/2023.10.05.560885Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/10/06/2023.10.05.560885.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2023/10/06/2023.10.05.560885.full.pdfDirect OA link when available
- Concepts
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Hypergravity, Zebrafish, Epigenetics, Danio, Biology, DNA methylation, Gene, Gene expression, Genetics, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
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