Epigenetic memory as a time integral over prior history of Polycomb phase separation Article Swipe
Jorine M. Eeftens
,
Manya Kapoor
,
Clifford P. Brangwynne
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.19.254706
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.08.19.254706
Structural organization of the genome into transcriptionally active euchromatin and silenced heterochromatin is essential for eukaryotic cell function. Heterochromatin is a more compact form of chromatin, and is associated with characteristic post-translational histone modifications and chromatin binding proteins. Phase-separation has recently been suggested as a mechanism for heterochromatin formation, through condensation of heterochromatin associated proteins. However, it is unclear how phase-separated condensates can contribute to stable and robust repression, particularly for heritable epigenetic changes. The Polycomb complex PRC1 is known to be key for heterochromatin formation, but the multitude of Polycomb proteins has hindered our understanding of their collective contribution to chromatin repression. Here, we take a quantitative live cell imaging approach to show that PRC1 proteins form multicomponent condensates through hetero-oligomerization. They preferentially seed at H3K27me3 marks, and subsequently write H2AK119Ub marks. Using optogenetics to nucleate local Polycomb condensates, we show that Polycomb phase separation can induce chromatin compaction, but phase separation is dispensable for maintenance of the compacted state. Our data are consistent with a model in which the time integral of historical Polycomb phase separation is progressively recorded in repressive histone marks, which subsequently drive chromatin compaction. These findings link the equilibrium thermodynamics of phase separation with the fundamentally non-equilibrium concept of epigenetic memory.
Related Topics
Concepts
Heterochromatin
Chromatin
Heterochromatin protein 1
Non-histone protein
Polycomb-group proteins
Epigenetics
Euchromatin
Histone
Biology
Constitutive heterochromatin
Cell biology
Genetics
Repressor
DNA
Gene expression
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.08.19.254706
- https://www.biorxiv.org/content/biorxiv/early/2020/08/19/2020.08.19.254706.full.pdf
- OA Status
- green
- Cited By
- 17
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3076995141
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3076995141Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.08.19.254706Digital Object Identifier
- Title
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Epigenetic memory as a time integral over prior history of Polycomb phase separationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-08-19Full publication date if available
- Authors
-
Jorine M. Eeftens, Manya Kapoor, Clifford P. BrangwynneList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.08.19.254706Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/08/19/2020.08.19.254706.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2020/08/19/2020.08.19.254706.full.pdfDirect OA link when available
- Concepts
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Heterochromatin, Chromatin, Heterochromatin protein 1, Non-histone protein, Polycomb-group proteins, Epigenetics, Euchromatin, Histone, Biology, Constitutive heterochromatin, Cell biology, Genetics, Repressor, DNA, Gene expression, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
17Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2022: 3, 2021: 13Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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