Epigenetic silencing of JAM3 promotes laryngeal squamous cell carcinoma development by inhibiting the Hippo pathway Article Swipe
Yue Jia
,
Jiaojiao Liu
,
Junqi Shi
,
Chunming Zhang
,
Xinfang Wang
,
Liting Zhao
,
Yi-Han Lou
,
Xiaoya Guan
,
Hui Huangfu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3892/or.2024.8861
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3892/or.2024.8861
Laryngeal squamous cell carcinoma (LSCC), which represents a significant proportion of head and neck squamous cell carcinoma cases, is often diagnosed at advanced stages, underscoring the urgent need for effective biomarkers and therapeutic targets. Junctional adhesion molecule 3 (JAM3) is implicated in various types of cancer; however, its role in LSCC remains unclear. Therefore, the present study aimed to investigate the epigenetic regulation and tumor‑suppressive functions and mechanisms of JAM3 in LSCC. Bioinformatics analysis and 5‑Aza‑2'‑deoxycytidine treatment, which restored JAM3 expression as confirmed by reverse transcription‑quantitative PCR and western blotting, revealed that aberrant hypermethylation of the JAM3 promoter was associated with reduced JAM3 expression and poorer clinical outcomes in patients with LSCC. In vitro experiments, including Cell Counting Kit 8, colony formation and Transwell assays, demonstrated that JAM3 overexpression inhibited LSCC cell proliferation, migration and invasion. Western blotting and immunofluorescence analysis revealed that the tumor‑suppressive function of JAM3 was mediated through activation of the Hippo pathway. By contrast, both in vitro and in vivo experiments showed that JAM3 knockdown enhanced these oncogenic behaviors by inhibiting the Hippo pathway, suggesting its critical tumor‑suppressive role. In conclusion, the results of the present study indicated that JAM3 may be epigenetically downregulated and could function as a novel tumor suppressor gene through the Hippo pathway in LSCC, offering insights into developing targeted treatments and diagnostics.
Related Topics
Concepts
Hippo signaling pathway
Biology
Cancer research
Gene silencing
Gene knockdown
Cell cycle
Oncogene
Epigenetics
Blot
Cancer
Cell
Head and neck squamous-cell carcinoma
Cell biology
Cell culture
Signal transduction
Head and neck cancer
Gene
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/or.2024.8861
- http://www.spandidos-publications.com/10.3892/or.2024.8861/download
- OA Status
- hybrid
- Cited By
- 1
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405886783
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4405886783Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/or.2024.8861Digital Object Identifier
- Title
-
Epigenetic silencing of JAM3 promotes laryngeal squamous cell carcinoma development by inhibiting the Hippo pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-30Full publication date if available
- Authors
-
Yue Jia, Jiaojiao Liu, Junqi Shi, Chunming Zhang, Xinfang Wang, Liting Zhao, Yi-Han Lou, Xiaoya Guan, Hui HuangfuList of authors in order
- Landing page
-
https://doi.org/10.3892/or.2024.8861Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/or.2024.8861/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://www.spandidos-publications.com/10.3892/or.2024.8861/downloadDirect OA link when available
- Concepts
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Hippo signaling pathway, Biology, Cancer research, Gene silencing, Gene knockdown, Cell cycle, Oncogene, Epigenetics, Blot, Cancer, Cell, Head and neck squamous-cell carcinoma, Cell biology, Cell culture, Signal transduction, Head and neck cancer, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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