Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position Article Swipe
Chee-Hong Chan
,
Pei Lin
,
Tse-Yen Yang
,
Bo‐Ying Bao
,
Jhen-Yang Jhong
,
Yui-Ping Weng
,
Te-Hsiu Lee
,
Hui-Fen Cheng
,
Te‐Ling Lu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0285217
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0285217
Apical-basal cell polarity must be tightly controlled for epithelial cyst and tubule formation, and these are important functional units in various epithelial organs. Polarization is achieved through the coordination of several molecules that divide cells into an apical domain and a basolateral domain, which are separated from tight and adherens junctions. Cdc42 regulates cytoskeletal organization and the tight junction protein ZO-1 at the apical margin of epithelial cell junctions. MST kinases control organ size through the regulation of cell proliferation and cell polarity. For example, MST1 relays the Rap1 signal to induce cell polarity and adhesion of lymphocytes. Our previous study showed that MST3 was involved in E-cadherin regulation and migration in MCF7 cells. In vivo , MST3 knockout mice exhibited higher ENaC expression at the apical site of renal tubules, resulting in hypertension. However, it was not clear whether MST3 was involved in cell polarity. Here, control MDCK cells, HA-MST3 and HA-MST3 kinase-dead (HA-MST3-KD) overexpressing MDCK cells were cultured in collagen or Matrigel. We found that the cysts of HA-MST3 cells were fewer and smaller than those of control MDCK cells; ZO-1 was delayed to the apical site of cysts and in cell-cell contact in the Ca 2+ switch assay. However, HA-MST3-KD cells exhibited multilumen cysts. Intensive F-actin stress fibers were observed in HA-MST3 cells with higher Cdc42 activity; in contrast, HA-MST3-KD cells had lower Cdc42 activity and weaker F-actin staining. In this study, we identified a new MST3 function in the establishment of cell polarity through Cdc42 regulation.
Related Topics
Concepts
Cell biology
Cell polarity
Adherens junction
CDC42
Matrigel
Biology
Cadherin
Cell
Actin
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0285217
- OA Status
- gold
- Cited By
- 1
- References
- 37
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4375955610Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0285217Digital Object Identifier
- Title
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Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 positionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-08Full publication date if available
- Authors
-
Chee-Hong Chan, Pei Lin, Tse-Yen Yang, Bo‐Ying Bao, Jhen-Yang Jhong, Yui-Ping Weng, Te-Hsiu Lee, Hui-Fen Cheng, Te‐Ling LuList of authors in order
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https://doi.org/10.1371/journal.pone.0285217Publisher landing page
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-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.1371/journal.pone.0285217Direct OA link when available
- Concepts
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Cell biology, Cell polarity, Adherens junction, CDC42, Matrigel, Biology, Cadherin, Cell, Actin, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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37Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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