Epitope-Based Specific Antibody Modification Article Swipe
Saki Horie
,
Kenji Mishiro
,
Mio Nishino
,
Inori Domae
,
Mitsuo Wakasugi
,
Tsukasa Matsunaga
,
Munetaka Kunishima
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-c0k4n
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-c0k4n
Modified antibodies play essential roles in various fields, such as analysis, diagnosis, and therapy, which require modified antibodies with optimal physical and biological properties. To this aim, the development of methods for site-selective antibody modification is crucial. Herein, we introduce a Fab region–selective antibody modification method using epitope-based affinity labeling. Although affinity labeling exploiting the high affinity between an antibody and its epitope may sound straightforward, it remains as a challenge probably due to target affinity loss caused by modification around the epitope binding site. By thoroughly screening of the modifying agent structure, reaction conditions, and purification methods, we achieved to develop an efficient method for the selective modification of the Fab region of the antibody while maintaining its high affinity for the epitope.
Related Topics
Concepts
Epitope
Antibody
Linear epitope
Chemistry
Epitope mapping
Computational biology
Combinatorial chemistry
Biology
Immunology
Metadata
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- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2023-c0k4n
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/641c205291074bccd02561ee/original/epitope-based-specific-antibody-modification.pdf
- OA Status
- gold
- References
- 5
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.26434/chemrxiv-2023-c0k4nDigital Object Identifier
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Epitope-Based Specific Antibody ModificationWork title
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preprintOpenAlex work type
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enPrimary language
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2023Year of publication
- Publication date
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2023-03-23Full publication date if available
- Authors
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Saki Horie, Kenji Mishiro, Mio Nishino, Inori Domae, Mitsuo Wakasugi, Tsukasa Matsunaga, Munetaka KunishimaList of authors in order
- Landing page
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https://doi.org/10.26434/chemrxiv-2023-c0k4nPublisher landing page
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/641c205291074bccd02561ee/original/epitope-based-specific-antibody-modification.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/641c205291074bccd02561ee/original/epitope-based-specific-antibody-modification.pdfDirect OA link when available
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Epitope, Antibody, Linear epitope, Chemistry, Epitope mapping, Computational biology, Combinatorial chemistry, Biology, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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5Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.target | 74 |
| abstract_inverted_index.Herein, | 37 |
| abstract_inverted_index.between | 57 |
| abstract_inverted_index.binding | 83 |
| abstract_inverted_index.develop | 101 |
| abstract_inverted_index.epitope | 62, 82 |
| abstract_inverted_index.fields, | 7 |
| abstract_inverted_index.methods | 30 |
| abstract_inverted_index.optimal | 19 |
| abstract_inverted_index.remains | 67 |
| abstract_inverted_index.require | 15 |
| abstract_inverted_index.various | 6 |
| abstract_inverted_index.Although | 50 |
| abstract_inverted_index.Modified | 0 |
| abstract_inverted_index.achieved | 99 |
| abstract_inverted_index.affinity | 48, 51, 56, 75, 120 |
| abstract_inverted_index.antibody | 33, 43, 59, 115 |
| abstract_inverted_index.crucial. | 36 |
| abstract_inverted_index.epitope. | 123 |
| abstract_inverted_index.labeling | 52 |
| abstract_inverted_index.methods, | 97 |
| abstract_inverted_index.modified | 16 |
| abstract_inverted_index.physical | 20 |
| abstract_inverted_index.probably | 71 |
| abstract_inverted_index.reaction | 93 |
| abstract_inverted_index.therapy, | 13 |
| abstract_inverted_index.analysis, | 10 |
| abstract_inverted_index.challenge | 70 |
| abstract_inverted_index.efficient | 103 |
| abstract_inverted_index.essential | 3 |
| abstract_inverted_index.introduce | 39 |
| abstract_inverted_index.labeling. | 49 |
| abstract_inverted_index.modifying | 90 |
| abstract_inverted_index.screening | 87 |
| abstract_inverted_index.selective | 107 |
| abstract_inverted_index.antibodies | 1, 17 |
| abstract_inverted_index.biological | 22 |
| abstract_inverted_index.diagnosis, | 11 |
| abstract_inverted_index.exploiting | 53 |
| abstract_inverted_index.structure, | 92 |
| abstract_inverted_index.thoroughly | 86 |
| abstract_inverted_index.conditions, | 94 |
| abstract_inverted_index.development | 28 |
| abstract_inverted_index.maintaining | 117 |
| abstract_inverted_index.properties. | 23 |
| abstract_inverted_index.modification | 34, 44, 79, 108 |
| abstract_inverted_index.purification | 96 |
| abstract_inverted_index.epitope-based | 47 |
| abstract_inverted_index.site-selective | 32 |
| abstract_inverted_index.straightforward, | 65 |
| abstract_inverted_index.region–selective | 42 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.04450229 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |