Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyte Article Swipe
Ling Li
,
Longsen Han
,
Jiaqi Zhang
,
Xiaohui Liu
,
Rujun Ma
,
Xiaojing Hou
,
Juan Ge
,
Qiang Wang
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10815
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10815
Epsins are a conserved family of endocytic adaptors essential for diverse biological events. However, its role in oocytes remains completely unknown. Here, we report that specific depletion of Epsin2 in mouse oocytes significantly disrupts meiotic progression. Confocal microscopy reveals that Epsin2 knockdown results in the failure of actin cap formation and polar body extrusion during meiosis, indicative of the importance of Epsin2 in polarity establishment and cytokinesis. In addition, spindle defects and chromosome misalignment are readily observed in oocytes depleted of Epsin2. Moreover, we find that Epsin2 knockdown markedly decreases the activity of Cdc42 in oocytes and importantly, that the dominant-positive mutant of Cdc42 (Cdc42Q61L) is capable of partially rescuing the deficient phenotypes of Epsin2-knockdown oocytes. Together, our data identify Epsin2 as a novel player in regulating oocyte maturation, and demonstrate that Epsin2 promotes polarity establishment and meiotic division via activating Cdc42.
Related Topics
Concepts
Cell biology
Polar body
Gene knockdown
Cytokinesis
Meiosis
Oocyte
CDC42
Chromosome segregation
Biology
Polarity (international relations)
Cell polarity
Chemistry
Cell division
Genetics
Actin
Chromosome
Embryo
Cell
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.10815
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10815&path%5B%5D=34235
- OA Status
- diamond
- Cited By
- 9
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2504439737
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2504439737Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.10815Digital Object Identifier
- Title
-
Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyteWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-07-24Full publication date if available
- Authors
-
Ling Li, Longsen Han, Jiaqi Zhang, Xiaohui Liu, Rujun Ma, Xiaojing Hou, Juan Ge, Qiang WangList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.10815Publisher landing page
- PDF URL
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https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10815&path%5B%5D=34235Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
diamondOpen access status per OpenAlex
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https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10815&path%5B%5D=34235Direct OA link when available
- Concepts
-
Cell biology, Polar body, Gene knockdown, Cytokinesis, Meiosis, Oocyte, CDC42, Chromosome segregation, Biology, Polarity (international relations), Cell polarity, Chemistry, Cell division, Genetics, Actin, Chromosome, Embryo, Cell, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2021: 1, 2020: 2, 2019: 2, 2018: 1Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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