Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation Article Swipe
Paola Muttathukunnel
,
Michael Wälti
,
Mostafa A. Aboouf
,
Christina Koester-Hegmann
,
Tatjana Haenggi
,
Max Gassmann
,
Patrizia Pannzanelli
,
Jean‐Marc Fritschy
,
Edith M. Schneider Gasser
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3190130/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3190130/v1
Myelination is a process that is tightly regulated by a variety of neurotrophic factors. Here, we show - by analyzing two transgenic mouse lines, one overexpressing EPO selectively in the brain Tg21 ( PDGFB-rhEPO ), and another with targeted removal of EPO receptors (EPORs) from oligodendrocyte progenitor cells (OPC)s ( Sox10-cre;EPOR fl/fl mice ) – a key function for EPO in regulating developmental brain myelination. Overexpression of EPO resulted in faster postnatal brain growth and myelination, an increased number of myelinating oligodendrocytes, faster axonal myelin ensheathment, and improved motor coordination. Inversely, targeted ablation of EPORs from OPCs reduced the number of mature oligodendrocytes and impaired motor coordination during the second postnatal week. Further, we found that EPORs are transiently expressed in the subventricular zone (SVZ) during the second postnatal week, and they stimulate the Erk1/2 pathway as well as the expression of essential oligodendrocyte pro-differentiation and pro-maturation transcripts (Nkx6.2 and Myrf), and the Nfatc2/calcineurin pathway. Our results reveal developmental time windows in which EPORs are expressed when therapies could be highly effective for stimulating oligodendrocyte maturation and myelination.
Related Topics
Concepts
Oligodendrocyte
Subventricular zone
Biology
OLIG2
SOX10
Neuroscience
Myelin
Erythropoietin
Calcineurin
Progenitor cell
Cell biology
Endocrinology
Internal medicine
Central nervous system
Transplantation
Stem cell
Medicine
Embryo
Neural crest
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3190130/v1
- https://www.researchsquare.com/article/rs-3190130/latest.pdf
- OA Status
- green
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386032004
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386032004Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3190130/v1Digital Object Identifier
- Title
-
Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturationWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-21Full publication date if available
- Authors
-
Paola Muttathukunnel, Michael Wälti, Mostafa A. Aboouf, Christina Koester-Hegmann, Tatjana Haenggi, Max Gassmann, Patrizia Pannzanelli, Jean‐Marc Fritschy, Edith M. Schneider GasserList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3190130/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-3190130/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3190130/latest.pdfDirect OA link when available
- Concepts
-
Oligodendrocyte, Subventricular zone, Biology, OLIG2, SOX10, Neuroscience, Myelin, Erythropoietin, Calcineurin, Progenitor cell, Cell biology, Endocrinology, Internal medicine, Central nervous system, Transplantation, Stem cell, Medicine, Embryo, Neural crestTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.oligodendrocyte | 46, 144, 175 |
| abstract_inverted_index.oligodendrocytes | 103 |
| abstract_inverted_index.oligodendrocytes, | 82 |
| abstract_inverted_index.Nfatc2/calcineurin | 154 |
| abstract_inverted_index.pro-differentiation | 145 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5042114789 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I202697423, https://openalex.org/I55143463 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.46000000834465027 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.15533355 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |