Esclerodermia localizada (morphea): revisão das opções terapêuticas atuais Article Swipe

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Letícia Benevenutti , Brenda Cássia de Souza , Lina Ramos ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.46919/archv6n4espec-15744

A esclerodermia localizada, também conhecida como morphea, é uma doença autoimune caracterizada pelo endurecimento e fibrose da pele e tecidos subjacentes, sem envolvimento sistêmico. Embora benigno em comparação à esclerodermia sistêmica, pode causar significativa morbidade estética e funcional. O tratamento da morphea ainda apresenta desafios devido à heterogeneidade das formas clínicas e à ausência de protocolos terapêuticos padronizados. Este artigo realiza uma revisão sistemática da literatura para avaliar as opções terapêuticas atualmente utilizadas no manejo da esclerodermia localizada, destacando eficácia, segurança e recomendações clínicas. Foram analisados artigos nacionais e internacionais publicados nos últimos 15 anos, com foco em estudos brasileiros. Entre as terapias mais estudadas, destacam-se corticosteroides tópicos e sistêmicos, imunossupressores fototerapia e agentes imunomoduladores. A análise sugere que o tratamento deve ser individualizado, levando em consideração a extensão e gravidade da doença, com monitoramento regular. Novas terapias emergentes e estudos clínicos são necessários para otimizar a abordagem terapêutica.

Related Topics

Medicine

Dermatology

Lichen Sclerosus

Concepts

Medicine Morphea Dermatology Lichen sclerosus

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Type: article
Language: pt
Landing Page: https://doi.org/10.46919/archv6n4espec-15744
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Title: Esclerodermia localizada (morphea): revisão das opções terapêuticas atuais

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Type: article

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Language: pt

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Publication year: 2025

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Publication date: 2025-08-11

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Authors: Letícia Benevenutti, Brenda Cássia de Souza, Lina Ramos

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Landing page: https://doi.org/10.46919/archv6n4espec-15744

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OA status: diamond

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OA URL: https://doi.org/10.46919/archv6n4espec-15744

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Concepts: Medicine, Morphea, Dermatology, Lichen sclerosus

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