Essential thrombocythemia with CALR mutation and recurrent stroke: two case reports and literature review Article Swipe
Rong Chen
,
Xiaodan Shi
,
Luojun Wang
,
Xuan Wang
,
Wei Jingya
,
Xiaogang Kang
,
Fang Du
,
Shan Gao
,
Fang Yang
,
Wen Jiang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/17562864221092093
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/17562864221092093
Cerebrovascular events, especially ischemic stroke, are common complications of essential thrombocythemia (ET). Compared to JAK2V617 F mutation, CALR mutation is considered as a lower risk factor of thrombosis in ET. Until now stroke in ET with CALR mutation has rarely been reported. We retrospectively investigated patients diagnosed with stroke and ET in Xijing hospital of Air Force Medical University, from 2015 to 2021. Clinical characteristics (including medical history, physical and auxiliary examination and prognosis) were recorded and associated literature was reviewed. Among the 19 patients diagnosed with both stroke and ET we retrieved, two cases were positive for CALR mutation. In case 1, a 71-year-old man developed the first ischemic event under the treatment of anagrelide, followed by a hemorrhagic stroke after receiving aspirin and clopidogrel for 4 months. Ischemic stroke reccurred and the neurological function deteriorated progressively. In case 2, a 44-year-old man presented with hypoxic-ischemic encephalopathy due to serious myocardial infarction and subsequent brain imaging indicated three times of ischemic stroke events. The patient gradually got improved through cytoreductive and antiplatelet therapy and rehabilitation. Literature review showed that cerebrovascular event is the most serious neurological complication of ET and may be the presenting symptom. Most of reported cases with ET accompanied by stroke were positive for JAK2 V617 F mutation, but with rare CALR mutation. ET with CALR mutation can cause both hemorrhagic and ischemic stroke. Identification of such rare causes of stroke is of great importance to provide precise and individualized prevention and therapy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/17562864221092093
- OA Status
- gold
- Cited By
- 4
- References
- 43
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4225776354Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/17562864221092093Digital Object Identifier
- Title
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Essential thrombocythemia with CALR mutation and recurrent stroke: two case reports and literature reviewWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
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Rong Chen, Xiaodan Shi, Luojun Wang, Xuan Wang, Wei Jingya, Xiaogang Kang, Fang Du, Shan Gao, Fang Yang, Wen JiangList of authors in order
- Landing page
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https://doi.org/10.1177/17562864221092093Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1177/17562864221092093Direct OA link when available
- Concepts
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Medicine, Stroke (engine), Essential thrombocythemia, Aspirin, Clopidogrel, Internal medicine, Pediatrics, Ischemic stroke, Cardiology, Ischemia, Platelet, Engineering, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
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2025: 1, 2023: 3Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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