Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens Article Swipe
Shunpei Yamanaka
,
Susumu Suzuki
,
Hideaki Ito
,
Sivasundaram Karnan
,
Ichiro Hanamura
,
Ikuko Okubo
,
Kazuhiro Yoshikawa
,
Shoya Ono
,
Taishi Takahara
,
Akira Satou
,
Toyonori Tsuzuki
,
Ryuzo Ueda
,
Tetsuya Ogawa
,
Yasushi Fujimoto
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24021722
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24021722
Patients with advanced/recurrent mucoepidermoid carcinoma (MEC) have a poor prognosis. This study aimed to establish and characterize human mucoepidermoid carcinoma cell lines from the initial surgical specimen and biopsy specimen upon recurrence from the same patient to provide a resource for MEC research. MEC specimens from the initial surgical procedure and biopsy upon recurrence were used to establish cell lines. The established cell lines were cytogenetically characterized using multi-color fluorescence in situ hybridization and detection, and the sequence of the CRTC1-MAML2 chimeric gene was determined. Furthermore, the susceptibility of head and neck mucoepidermoid carcinoma to standard treatment drugs such as cisplatin, 5-fluorouracil, and cetuximab was investigated. We successfully established unique MEC cell lines, AMU-MEC1, from an initial surgical specimen and AMU-MEC1-R1 and AMU-MEC1-R2 from the recurrent biopsy specimen in the same patient. These cell lines exhibited epithelial morphology and developed in vitro-like cobblestones. They shared eight chromosomal abnormalities, including der(19)ins(19;11)(p13;?), which resulted in a chimeric CRTC1-MAML2 gene, indicating the same origin of the cell lines. The susceptibility of all cell lines to cisplatin and 5-fluorouracil was low. Interestingly, EGFR dependency for cell growth decreased in AMU-MEC-R1 and AMU-MEC-R2 but was retained in AMU-MEC1. These cytogenetic and biochemical findings suggest that the established cell lines can be used to investigate the disease progression mechanisms and develop novel therapeutics for MEC.
Related Topics
Concepts
Mucoepidermoid carcinoma
Cell culture
Biopsy
Cisplatin
Fluorescence in situ hybridization
Cancer research
Carcinoma
Pathology
Cell
Biology
Medicine
Chemistry
Gene
Internal medicine
Chemotherapy
Genetics
Chromosome
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24021722
- https://www.mdpi.com/1422-0067/24/2/1722/pdf?version=1674124483
- OA Status
- gold
- Cited By
- 1
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4316664720
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4316664720Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms24021722Digital Object Identifier
- Title
-
Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy SpecimensWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-15Full publication date if available
- Authors
-
Shunpei Yamanaka, Susumu Suzuki, Hideaki Ito, Sivasundaram Karnan, Ichiro Hanamura, Ikuko Okubo, Kazuhiro Yoshikawa, Shoya Ono, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Ryuzo Ueda, Tetsuya Ogawa, Yasushi FujimotoList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms24021722Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/24/2/1722/pdf?version=1674124483Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/24/2/1722/pdf?version=1674124483Direct OA link when available
- Concepts
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Mucoepidermoid carcinoma, Cell culture, Biopsy, Cisplatin, Fluorescence in situ hybridization, Cancer research, Carcinoma, Pathology, Cell, Biology, Medicine, Chemistry, Gene, Internal medicine, Chemotherapy, Genetics, ChromosomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| countries_distinct_count | 1 |
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| corresponding_institution_ids | https://openalex.org/I16528096 |
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