Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US States Article Swipe
Jagpreet Chhatwal
,
Peter P. Mueller
,
Qiushi Chen
,
Neeti Kulkarni
,
Madeline Adee
,
Gary A. Zarkin
,
Marc R. Larochelle
,
Amy B. Knudsen
,
Carolina Barbosa
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1001/jamanetworkopen.2023.14925
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1001/jamanetworkopen.2023.14925
Importance In 2021, more than 80 000 US residents died from an opioid overdose. Public health intervention initiatives, such as the Helping to End Addiction Long-term (HEALing) Communities Study (HCS), are being launched with the goal of reducing opioid-related overdose deaths (OODs). Objective To estimate the change in the projected number of OODs under different scenarios of the duration of sustainment of interventions, compared with the status quo. Design, Setting, and Participants This decision analytical model simulated the opioid epidemic in the 4 states participating in the HCS (ie, Kentucky, Massachusetts, New York, and Ohio) from 2020 to 2026. Participants were a simulated population transitioning from opioid misuse to opioid use disorder (OUD), overdose, treatment, and relapse. The model was calibrated using 2015 to 2020 data from the National Survey on Drug Use and Health, the US Centers for Disease Control and Prevention, and other sources for each state. The model accounts for reduced initiation of medications for OUD (MOUDs) and increased OODs during the COVID-19 pandemic. Exposure Increasing MOUD initiation by 2- or 5-fold, improving MOUD retention to the rates achieved in clinical trial settings, increasing naloxone distribution efforts, and furthering safe opioid prescribing. An initial 2-year duration of interventions was simulated, with potential sustainment for up to 3 additional years. Main Outcomes and Measures Projected reduction in number of OODs under different combinations and durations of sustainment of interventions. Results Compared with the status quo, the estimated annual reduction in OODs at the end of the second year of interventions was 13% to 17% in Kentucky, 17% to 27% in Massachusetts, 15% to 22% in New York, and 15% to 22% in Ohio. Sustaining all interventions for an additional 3 years was estimated to reduce the annual number of OODs at the end of the fifth year by 18% to 27% in Kentucky, 28% to 46% in Massachusetts, 22% to 34% in New York, and 25% to 41% in Ohio. The longer the interventions were sustained, the better the outcomes; however, these positive gains would be washed out if interventions were not sustained. Conclusions and Relevance In this decision analytical model study of the opioid epidemic in 4 US states, sustained implementation of interventions, including increased delivery of MOUDs and naloxone supply, was found to be needed to reduce OODs and prevent deaths from increasing again.
Related Topics
Concepts
Opioid overdose
Harm reduction
Psychological intervention
(+)-Naloxone
Heroin
Psychology
Population
Opioid
Public health
Methadone
Medicine
Psychiatry
Environmental health
Drug
Nursing
Internal medicine
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1001/jamanetworkopen.2023.14925
- https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2805808/chhatwal_2023_oi_230461_1685637298.765.pdf
- OA Status
- gold
- Cited By
- 30
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379966380
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4379966380Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1001/jamanetworkopen.2023.14925Digital Object Identifier
- Title
-
Estimated Reductions in Opioid Overdose Deaths With Sustainment of Public Health Interventions in 4 US StatesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-09Full publication date if available
- Authors
-
Jagpreet Chhatwal, Peter P. Mueller, Qiushi Chen, Neeti Kulkarni, Madeline Adee, Gary A. Zarkin, Marc R. Larochelle, Amy B. Knudsen, Carolina BarbosaList of authors in order
- Landing page
-
https://doi.org/10.1001/jamanetworkopen.2023.14925Publisher landing page
- PDF URL
-
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2805808/chhatwal_2023_oi_230461_1685637298.765.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2805808/chhatwal_2023_oi_230461_1685637298.765.pdfDirect OA link when available
- Concepts
-
Opioid overdose, Harm reduction, Psychological intervention, (+)-Naloxone, Heroin, Psychology, Population, Opioid, Public health, Methadone, Medicine, Psychiatry, Environmental health, Drug, Nursing, Internal medicine, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 15, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2023-06-09 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W4220663534, https://openalex.org/W6713185511, https://openalex.org/W2800278321, https://openalex.org/W2626234167, https://openalex.org/W2466771592, https://openalex.org/W4236858835, https://openalex.org/W2889035642, https://openalex.org/W2619968007, https://openalex.org/W3005454586, https://openalex.org/W2890254074, https://openalex.org/W2990187794, https://openalex.org/W3091176243, https://openalex.org/W3103545929, https://openalex.org/W2888377253, https://openalex.org/W3094663502, https://openalex.org/W4283447559, https://openalex.org/W4321163565, https://openalex.org/W3033620496, https://openalex.org/W3153032010, https://openalex.org/W3182511240, https://openalex.org/W2401653577, https://openalex.org/W4206608028, https://openalex.org/W2913621448, https://openalex.org/W2608446001, https://openalex.org/W4241011144, https://openalex.org/W2729232923, https://openalex.org/W2248705888, https://openalex.org/W2058056848, https://openalex.org/W2315302680, https://openalex.org/W979688486, https://openalex.org/W2898228791, https://openalex.org/W4226231332, https://openalex.org/W3185846277, https://openalex.org/W3156042293, https://openalex.org/W3161062870, https://openalex.org/W3156324838, https://openalex.org/W4310131504, https://openalex.org/W2034380059, https://openalex.org/W3132147424, https://openalex.org/W4282916832, https://openalex.org/W3043975829, https://openalex.org/W3096940405, https://openalex.org/W2760696327, https://openalex.org/W2993088220, https://openalex.org/W2731109961, https://openalex.org/W2745114458, https://openalex.org/W2955994854, https://openalex.org/W2599608130, https://openalex.org/W2802034737, https://openalex.org/W2910383399, https://openalex.org/W2191045458, https://openalex.org/W2889861957 |
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