Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer Article Swipe
Naoko Honma
,
Tomio Arai
,
Yoko Matsuda
,
Yosuke Fukunaga
,
Masaaki Muramatsu
,
Shinobu Ikeda
,
Yuri Akishima‐Fukasawa
,
Noriko Yamamoto
,
Hiroshi Kawachi
,
Yuichi Ishikawa
,
Kengo Takeuchi
,
Tetuo Mikami
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24054502
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24054502
The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unknown, we previously showed that a shorter allele (germline) increased the risk of colon cancer in older women, whereas it decreased it in younger postmenopausal women. ESR2-CA and ER-β expressions were examined in cancerous (Ca) and non-cancerous (NonCa) tissue pairs from 114 postmenopausal women, and comparisons were made considering tissue types, age/locus, and the mismatch repair protein (MMR) status. ESR2-CA repeats <22/≥22 were designated as ‘S’/‘L’, respectively, resulting in genotypes SS/nSS (=SL&LL). In NonCa, the rate of the SS genotype and ER-β expression level were significantly higher in right-sided cases of women ≥70 (≥70Rt) than in those in the others. A decreased ER-β expression in Ca compared with NonCa was observed in proficient-MMR, but not in deficient-MMR. In NonCa, but not in Ca, ER-β expression was significantly higher in SS than in nSS. ≥70Rt cases were characterized by NonCa with a high rate of SS genotype or high ER-β expression. The germline ESR2-CA genotype and resulting ER-β expression were considered to affect the clinical characteristics (age/locus/MMR status) of colon cancer, supporting our previous findings.
Related Topics
Concepts
Estrogen receptor
Colorectal cancer
Estrogen receptor alpha
Cytosine
Estrogen
Selective estrogen receptor modulator
Internal medicine
Gene
Postmenopausal women
Cancer research
Estrogen receptor beta
Polymorphism (computer science)
Endocrinology
Breast cancer
Biology
Medicine
Genetics
Cancer
Allele
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24054502
- https://www.mdpi.com/1422-0067/24/5/4502/pdf?version=1678436999
- OA Status
- gold
- Cited By
- 3
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4322501554
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4322501554Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms24054502Digital Object Identifier
- Title
-
Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon CancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-24Full publication date if available
- Authors
-
Naoko Honma, Tomio Arai, Yoko Matsuda, Yosuke Fukunaga, Masaaki Muramatsu, Shinobu Ikeda, Yuri Akishima‐Fukasawa, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Kengo Takeuchi, Tetuo MikamiList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms24054502Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/24/5/4502/pdf?version=1678436999Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/24/5/4502/pdf?version=1678436999Direct OA link when available
- Concepts
-
Estrogen receptor, Colorectal cancer, Estrogen receptor alpha, Cytosine, Estrogen, Selective estrogen receptor modulator, Internal medicine, Gene, Postmenopausal women, Cancer research, Estrogen receptor beta, Polymorphism (computer science), Endocrinology, Breast cancer, Biology, Medicine, Genetics, Cancer, AlleleTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2058409189, https://openalex.org/W2049515408, https://openalex.org/W2141130185, https://openalex.org/W3014547684, https://openalex.org/W3112209279, https://openalex.org/W1950345886, https://openalex.org/W2115876798, https://openalex.org/W2115817355, https://openalex.org/W2060899994, https://openalex.org/W2138314493, https://openalex.org/W2139533413, https://openalex.org/W4206083582, https://openalex.org/W2041987808, https://openalex.org/W1518876876, https://openalex.org/W2031880571, https://openalex.org/W2111724604, https://openalex.org/W1992278934, https://openalex.org/W1969637213, https://openalex.org/W2112719911, https://openalex.org/W1973778455, https://openalex.org/W1822314864, https://openalex.org/W2008496640, https://openalex.org/W3164652928, https://openalex.org/W2305574656, https://openalex.org/W1989513214, https://openalex.org/W27697048, https://openalex.org/W6638689613, https://openalex.org/W1555570895, https://openalex.org/W4245045357 |
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| corresponding_author_ids | https://openalex.org/A5048766632 |
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