Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific Article Swipe
Eugene S.J. Tan
,
Wan Ting Tay
,
Tiew‐Hwa Katherine Teng
,
David Sim
,
Kui Toh Gerard Leong
,
Poh Shuan Daniel Yeo
,
Hean Yee Ong
,
Fazlur Jaufeerally
,
Tze Pin Ng
,
Katrina Poppe
,
Mayanna Lund
,
Gerard Devlin
,
Richard W. Troughton
,
Lieng Hsi Ling
,
Mark Richards
,
Robert N. Doughty
,
Carolyn S.P. Lam
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1136/heartjnl-2018-314077
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1136/heartjnl-2018-314077
Objective Ethnic differences in the prevalence of atrial fibrillation (AF) in heart failure (HF) remain unclear. We compared the prevalence and clinical correlates of AF among different ethnicities in an Asian-Pacific population with HF. Methods Patients with validated HF were prospectively studied across Singapore and New Zealand (NZ). Results Among 1746 patients with HF (62% Asian, 26% women, mean age 66 (SD 13) years, mean ejection fraction (EF) 37 (SD 16%), 39% had AF. The prevalence of AF was markedly lower in Singapore-Asians than NZ-Europeans (24% vs 63%; p<0.001), even after adjusting for age, clinical and echocardiographic covariates, regardless of EF group (p interaction for EF=0.39). Patients with AF were older, had higher body mass index and were more likely to have a history of hypertension, stroke, peripheral vascular disease, renal disease, chronic respiratory disease and increased alcohol intake, but less likely to have diabetes. Clinical correlates were similar for Asians and NZ-Europeans, except diabetes: Asian diabetic patients with HF had less AF compared with Asian patients without diabetes (OR 0.66, 95% CI 0.50 to 0.88), whereas among NZ-Europeans there was no significant association between diabetes and AF (OR 1.22, 95% CI 0.85 to 1.75) (p interaction for ethnicity=0.01). AF was associated with a higher crude composite outcome of mortality and HF hospitalisations at 2 years (HR 1.19, 95% CI 1.02 to 1.38). Conclusion There is a strikingly lower prevalence of AF among Asian compared with NZ-European patients with HF. The underlying mechanisms for the lower prevalence of AF among Asians, particularly in the presence of diabetes, deserve further study. Trial registration number ACTRN12610000374066.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/heartjnl-2018-314077
- https://heart.bmj.com/content/heartjnl/105/11/842.full.pdf
- OA Status
- bronze
- Cited By
- 23
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2910478229
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2910478229Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/heartjnl-2018-314077Digital Object Identifier
- Title
-
Ethnic differences in atrial fibrillation in patients with heart failure from Asia-PacificWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-01-19Full publication date if available
- Authors
-
Eugene S.J. Tan, Wan Ting Tay, Tiew‐Hwa Katherine Teng, David Sim, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze Pin Ng, Katrina Poppe, Mayanna Lund, Gerard Devlin, Richard W. Troughton, Lieng Hsi Ling, Mark Richards, Robert N. Doughty, Carolyn S.P. LamList of authors in order
- Landing page
-
https://doi.org/10.1136/heartjnl-2018-314077Publisher landing page
- PDF URL
-
https://heart.bmj.com/content/heartjnl/105/11/842.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://heart.bmj.com/content/heartjnl/105/11/842.full.pdfDirect OA link when available
- Concepts
-
Medicine, Internal medicine, Atrial fibrillation, Diabetes mellitus, Heart failure, Ejection fraction, Stroke (engine), Body mass index, Population, Cardiology, Endocrinology, Engineering, Mechanical engineering, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
23Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 5, 2022: 4, 2021: 6, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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