EV-mediated asymmetrical crosstalk between CAFs and cancer cells in the tumor microenvironment Article Swipe
Alice Santi
,
Annalisa Moccia
,
Anna Caselli
,
Paolo Cirri
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbcan.2025.189380
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbcan.2025.189380
Tumor is a complex tissue composed of both genetically transformed cancer cells and the cells of the tumor microenvironment, including connective cells, immune cells, and endothelial cells that actively contribute to the maintenance of the tumor and, consequently, to its progression. As for any other tissue, the communication between cells of the tumor microenvironment plays an essential role in determining the architecture and physiology of the tumor tissue. This intercellular communication is classically mediated by soluble factors (such as cytokines and growth factors) but it has been shown that the extracellular vesicle (EV) trafficking may also contribute to tumor growth and progression. In this paper, we discuss the EV-mediated transfer of proteins between cancer cells and cancer-associated fibroblasts (CAFs) in an attempt to propose an interpretation of the relationships between these two cell types within the tumor microenvironment. In particular, we propose that this type of crosstalk between cancer cells and CAFs is asymmetrical: on the one hand, cancer cells secrete signaling protein-bearing exosomes that induce the trans-differentiation of neighboring fibroblasts into CAFs; on the other hand, CAFs transfer biomass to cancer cells through ectosome trafficking, thus supporting cancer cell proliferation.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bbcan.2025.189380
- OA Status
- hybrid
- Cited By
- 1
- References
- 81
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411992077Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.bbcan.2025.189380Digital Object Identifier
- Title
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EV-mediated asymmetrical crosstalk between CAFs and cancer cells in the tumor microenvironmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
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2025-07-03Full publication date if available
- Authors
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Alice Santi, Annalisa Moccia, Anna Caselli, Paolo CirriList of authors in order
- Landing page
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https://doi.org/10.1016/j.bbcan.2025.189380Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.bbcan.2025.189380Direct OA link when available
- Concepts
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Crosstalk, Tumor microenvironment, Cancer cell, Tumor cells, Cell biology, Cancer research, Physics, Biology, Cancer, Medicine, Optics, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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81Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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