Evaluating colonoscopy screening intervals in patients with Lynch syndrome from a large Canadian registry Article Swipe
Melyssa Aronson
,
Robert Gryfe
,
Yun‐Hee Choi
,
Kara Semotiuk
,
Spring Holter
,
Thomas R. Ward
,
Steve Gallinger
,
Zane Cohen
,
Laurent Briollais
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/jnci/djad058
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/jnci/djad058
Background Lynch syndrome (LS) screening guidelines originally recommended colonoscopy every 1 to 2 years, beginning between the ages of 20 and 25 years. Recent studies have questioned the benefits of these short screening intervals in preventing colorectal cancer (CRC). Our goal is to determine how colonoscopy screening intervals impact CRC in patients with LS. Methods We analyzed the demographics, screening practices, and outcomes of patients with LS identified through the clinic based Familial Gastrointestinal Cancer Registry at the Zane Cohen Centre, Sinai Health System, Toronto, Canada. Results A total of 429 patients with LS were identified with median follow-up of 9.2 years; 44 developed CRC. We found a positive trend between shorter screening intervals and the number of adenomas detected during colonoscopy. Any new adenoma detected at screening decreased 10-year CRC incidence by 11.3%. For MLH1 carriers, a screening interval of 1-2 years vs 2-3 years led to a 20-year cumulative CRC risk reduction of 28% and 14% in females and males, respectively. For MSH2 carriers, this risk reduction was 29% and 17%, respectively, and for male MSH6 carriers 18%. Individuals without any adenomas detected (53.4% of LS carriers) had an increased 20-year CRC risk of 25.7% and 57.2% for women and men, respectively, compared with those diagnosed with adenomas at screening. Conclusions The recommended colonoscopy screening interval of 1-2 years is efficient at detecting adenomas and reducing CRC risk. The observation that 53.4% of LS patients never had an adenoma warrants further investigation about a possible adenoma-free pathway.
Related Topics
Concepts
Medicine
Colonoscopy
Lynch syndrome
Adenoma
Colorectal cancer
Incidence (geometry)
Internal medicine
Confidence interval
Cancer
Optics
DNA mismatch repair
Physics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jnci/djad058
- OA Status
- green
- Cited By
- 12
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4360942155
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4360942155Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/jnci/djad058Digital Object Identifier
- Title
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Evaluating colonoscopy screening intervals in patients with Lynch syndrome from a large Canadian registryWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-25Full publication date if available
- Authors
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Melyssa Aronson, Robert Gryfe, Yun‐Hee Choi, Kara Semotiuk, Spring Holter, Thomas R. Ward, Steve Gallinger, Zane Cohen, Laurent BriollaisList of authors in order
- Landing page
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https://doi.org/10.1093/jnci/djad058Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10323893/pdf/djad058.pdfDirect OA link when available
- Concepts
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Medicine, Colonoscopy, Lynch syndrome, Adenoma, Colorectal cancer, Incidence (geometry), Internal medicine, Confidence interval, Cancer, Optics, DNA mismatch repair, PhysicsTop concepts (fields/topics) attached by OpenAlex
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12Total citation count in OpenAlex
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2025: 3, 2024: 7, 2023: 2Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.MLH1 | 136 |
| abstract_inverted_index.MSH2 | 165 |
| abstract_inverted_index.MSH6 | 178 |
| abstract_inverted_index.Zane | 79 |
| abstract_inverted_index.ages | 18 |
| abstract_inverted_index.goal | 41 |
| abstract_inverted_index.have | 26 |
| abstract_inverted_index.male | 177 |
| abstract_inverted_index.men, | 203 |
| abstract_inverted_index.risk | 153, 168, 195 |
| abstract_inverted_index.that | 233 |
| abstract_inverted_index.this | 167 |
| abstract_inverted_index.were | 95 |
| abstract_inverted_index.with | 53, 66, 93, 97, 206, 209 |
| abstract_inverted_index.25.7% | 197 |
| abstract_inverted_index.53.4% | 234 |
| abstract_inverted_index.57.2% | 199 |
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| abstract_inverted_index.Lynch | 2 |
| abstract_inverted_index.Sinai | 82 |
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| abstract_inverted_index.based | 72 |
| abstract_inverted_index.every | 10 |
| abstract_inverted_index.found | 107 |
| abstract_inverted_index.never | 238 |
| abstract_inverted_index.risk. | 230 |
| abstract_inverted_index.short | 32 |
| abstract_inverted_index.these | 31 |
| abstract_inverted_index.those | 207 |
| abstract_inverted_index.total | 89 |
| abstract_inverted_index.trend | 110 |
| abstract_inverted_index.women | 201 |
| abstract_inverted_index.years | 143, 146, 221 |
| abstract_inverted_index.(53.4% | 186 |
| abstract_inverted_index.(CRC). | 39 |
| abstract_inverted_index.11.3%. | 134 |
| abstract_inverted_index.Cancer | 75 |
| abstract_inverted_index.Health | 83 |
| abstract_inverted_index.Recent | 24 |
| abstract_inverted_index.cancer | 38 |
| abstract_inverted_index.clinic | 71 |
| abstract_inverted_index.during | 121 |
| abstract_inverted_index.impact | 49 |
| abstract_inverted_index.males, | 162 |
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| abstract_inverted_index.number | 117 |
| abstract_inverted_index.years, | 14 |
| abstract_inverted_index.years. | 23 |
| abstract_inverted_index.years; | 102 |
| abstract_inverted_index.10-year | 130 |
| abstract_inverted_index.20-year | 150, 193 |
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| abstract_inverted_index.Centre, | 81 |
| abstract_inverted_index.Methods | 55 |
| abstract_inverted_index.Results | 87 |
| abstract_inverted_index.System, | 84 |
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| abstract_inverted_index.between | 16, 111 |
| abstract_inverted_index.females | 160 |
| abstract_inverted_index.further | 243 |
| abstract_inverted_index.shorter | 112 |
| abstract_inverted_index.studies | 25 |
| abstract_inverted_index.through | 69 |
| abstract_inverted_index.without | 182 |
| abstract_inverted_index.Abstract | 0 |
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| abstract_inverted_index.Registry | 76 |
| abstract_inverted_index.Toronto, | 85 |
| abstract_inverted_index.adenomas | 119, 184, 210, 226 |
| abstract_inverted_index.analyzed | 57 |
| abstract_inverted_index.benefits | 29 |
| abstract_inverted_index.carriers | 179 |
| abstract_inverted_index.compared | 205 |
| abstract_inverted_index.detected | 120, 126, 185 |
| abstract_inverted_index.interval | 140, 218 |
| abstract_inverted_index.outcomes | 63 |
| abstract_inverted_index.pathway. | 249 |
| abstract_inverted_index.patients | 52, 65, 92, 237 |
| abstract_inverted_index.positive | 109 |
| abstract_inverted_index.possible | 247 |
| abstract_inverted_index.reducing | 228 |
| abstract_inverted_index.syndrome | 3 |
| abstract_inverted_index.warrants | 242 |
| abstract_inverted_index.beginning | 15 |
| abstract_inverted_index.carriers) | 189 |
| abstract_inverted_index.carriers, | 137, 166 |
| abstract_inverted_index.decreased | 129 |
| abstract_inverted_index.detecting | 225 |
| abstract_inverted_index.determine | 44 |
| abstract_inverted_index.developed | 104 |
| abstract_inverted_index.diagnosed | 208 |
| abstract_inverted_index.efficient | 223 |
| abstract_inverted_index.follow-up | 99 |
| abstract_inverted_index.incidence | 132 |
| abstract_inverted_index.increased | 192 |
| abstract_inverted_index.intervals | 34, 48, 114 |
| abstract_inverted_index.reduction | 154, 169 |
| abstract_inverted_index.screening | 5, 33, 47, 60, 113, 128, 139, 217 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.colorectal | 37 |
| abstract_inverted_index.cumulative | 151 |
| abstract_inverted_index.guidelines | 6 |
| abstract_inverted_index.identified | 68, 96 |
| abstract_inverted_index.originally | 7 |
| abstract_inverted_index.practices, | 61 |
| abstract_inverted_index.preventing | 36 |
| abstract_inverted_index.questioned | 27 |
| abstract_inverted_index.screening. | 212 |
| abstract_inverted_index.Conclusions | 213 |
| abstract_inverted_index.Individuals | 181 |
| abstract_inverted_index.colonoscopy | 9, 46, 216 |
| abstract_inverted_index.observation | 232 |
| abstract_inverted_index.recommended | 8, 215 |
| abstract_inverted_index.adenoma-free | 248 |
| abstract_inverted_index.colonoscopy. | 122 |
| abstract_inverted_index.demographics, | 59 |
| abstract_inverted_index.investigation | 244 |
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| abstract_inverted_index.respectively. | 163 |
| abstract_inverted_index.Gastrointestinal | 74 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5074877417 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I185261750, https://openalex.org/I210557978, https://openalex.org/I4210130843 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.92425307 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |