Evaluating Cryo‐TEM Reconstruction Accuracy of Self‐Assembled Polymer Nanostructures Article Swipe
Xubo Luo
,
M. Seidler
,
Yen Jea Lee
,
Tianyi Yu
,
Ronald N. Zuckermann
,
Nitash P. Balsara
,
Brooks A. Abel
,
David Prendergast
,
Xi Jiang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/marc.202400589
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/marc.202400589
Cryogenic transmission electron microscopy (cryo‐TEM) combined with single particle analysis (SPA) is an emerging imaging approach for soft materials. However, the accuracy of SPA‐reconstructed nanostructures, particularly those formed by synthetic polymers, remains uncertain due to potential packing heterogeneity of the nanostructures. In this study, the combination of molecular dynamics (MD) simulations and image simulations is utilized to validate the accuracy of cryo‐TEM 3D reconstructions of self‐assembled polypeptoid fibril nanostructures. Using CryoSPARC software, image simulations, 2D classifications, ab initio reconstructions, and homogenous refinements are performed. By comparing the results with atomic models, the recovery of molecular details is assessed, heterogeneous structures are identified, and the influence of extraction location on the reconstructions is evaluated. These findings confirm the fidelity of single particle analysis in accurately resolving complex structural characteristics and heterogeneous structures, exhibiting its potential as a valuable tool for detailed structural analysis of synthetic polymers and soft materials.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/marc.202400589
- OA Status
- green
- Cited By
- 1
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402480805
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4402480805Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/marc.202400589Digital Object Identifier
- Title
-
Evaluating Cryo‐TEM Reconstruction Accuracy of Self‐Assembled Polymer NanostructuresWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-12Full publication date if available
- Authors
-
Xubo Luo, M. Seidler, Yen Jea Lee, Tianyi Yu, Ronald N. Zuckermann, Nitash P. Balsara, Brooks A. Abel, David Prendergast, Xi JiangList of authors in order
- Landing page
-
https://doi.org/10.1002/marc.202400589Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.osti.gov/biblio/2440913Direct OA link when available
- Concepts
-
Nanostructure, Materials science, Polymer, Transmission electron microscopy, Molecular dynamics, Nanotechnology, Particle (ecology), Chemistry, Computational chemistry, Composite material, Oceanography, GeologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4402480805 |
|---|---|
| doi | https://doi.org/10.1002/marc.202400589 |
| ids.doi | https://doi.org/10.1002/marc.202400589 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39264522 |
| ids.openalex | https://openalex.org/W4402480805 |
| fwci | 1.44772447 |
| mesh[0].qualifier_ui | Q000379 |
| mesh[0].descriptor_ui | D020285 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | methods |
| mesh[0].descriptor_name | Cryoelectron Microscopy |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D049329 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Nanostructures |
| mesh[2].qualifier_ui | Q000737 |
| mesh[2].descriptor_ui | D011108 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | chemistry |
| mesh[2].descriptor_name | Polymers |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D056004 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Molecular Dynamics Simulation |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D046529 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Microscopy, Electron, Transmission |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D010316 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Particle Size |
| type | article |
| title | Evaluating Cryo‐TEM Reconstruction Accuracy of Self‐Assembled Polymer Nanostructures |
| awards[0].id | https://openalex.org/G6254630845 |
| awards[0].funder_id | https://openalex.org/F4320337480 |
| awards[0].display_name | |
| awards[0].funder_award_id | KC11BN |
| awards[0].funder_display_name | Basic Energy Sciences |
| biblio.issue | 1 |
| biblio.volume | 46 |
| biblio.last_page | e2400589 |
| biblio.first_page | e2400589 |
| topics[0].id | https://openalex.org/T10857 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994999766349792 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1315 |
| topics[0].subfield.display_name | Structural Biology |
| topics[0].display_name | Advanced Electron Microscopy Techniques and Applications |
| topics[1].id | https://openalex.org/T12039 |
| topics[1].field.id | https://openalex.org/fields/25 |
| topics[1].field.display_name | Materials Science |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2508 |
| topics[1].subfield.display_name | Surfaces, Coatings and Films |
| topics[1].display_name | Electron and X-Ray Spectroscopy Techniques |
| topics[2].id | https://openalex.org/T11948 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.991599977016449 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2505 |
| topics[2].subfield.display_name | Materials Chemistry |
| topics[2].display_name | Machine Learning in Materials Science |
| funders[0].id | https://openalex.org/F4320306084 |
| funders[0].ror | https://ror.org/01bj3aw27 |
| funders[0].display_name | U.S. Department of Energy |
| funders[1].id | https://openalex.org/F4320332359 |
| funders[1].ror | https://ror.org/00mmn6b08 |
| funders[1].display_name | Office of Science |
| funders[2].id | https://openalex.org/F4320337480 |
| funders[2].ror | https://ror.org/05mg91w61 |
| funders[2].display_name | Basic Energy Sciences |
| is_xpac | False |
| apc_list.value | 4120 |
| apc_list.currency | USD |
| apc_list.value_usd | 4120 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C186187911 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7470256090164185 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1093894 |
| concepts[0].display_name | Nanostructure |
| concepts[1].id | https://openalex.org/C192562407 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6777125597000122 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[1].display_name | Materials science |
| concepts[2].id | https://openalex.org/C521977710 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6388581395149231 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q81163 |
| concepts[2].display_name | Polymer |
| concepts[3].id | https://openalex.org/C146088050 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5384182333946228 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q744818 |
| concepts[3].display_name | Transmission electron microscopy |
| concepts[4].id | https://openalex.org/C59593255 |
| concepts[4].level | 2 |
| concepts[4].score | 0.523200511932373 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q901663 |
| concepts[4].display_name | Molecular dynamics |
| concepts[5].id | https://openalex.org/C171250308 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5139124393463135 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[5].display_name | Nanotechnology |
| concepts[6].id | https://openalex.org/C2778517922 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4959200322628021 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7140482 |
| concepts[6].display_name | Particle (ecology) |
| concepts[7].id | https://openalex.org/C185592680 |
| concepts[7].level | 0 |
| concepts[7].score | 0.1672351360321045 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[7].display_name | Chemistry |
| concepts[8].id | https://openalex.org/C147597530 |
| concepts[8].level | 1 |
| concepts[8].score | 0.08944979310035706 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q369472 |
| concepts[8].display_name | Computational chemistry |
| concepts[9].id | https://openalex.org/C159985019 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[9].display_name | Composite material |
| concepts[10].id | https://openalex.org/C111368507 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q43518 |
| concepts[10].display_name | Oceanography |
| concepts[11].id | https://openalex.org/C127313418 |
| concepts[11].level | 0 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q1069 |
| concepts[11].display_name | Geology |
| keywords[0].id | https://openalex.org/keywords/nanostructure |
| keywords[0].score | 0.7470256090164185 |
| keywords[0].display_name | Nanostructure |
| keywords[1].id | https://openalex.org/keywords/materials-science |
| keywords[1].score | 0.6777125597000122 |
| keywords[1].display_name | Materials science |
| keywords[2].id | https://openalex.org/keywords/polymer |
| keywords[2].score | 0.6388581395149231 |
| keywords[2].display_name | Polymer |
| keywords[3].id | https://openalex.org/keywords/transmission-electron-microscopy |
| keywords[3].score | 0.5384182333946228 |
| keywords[3].display_name | Transmission electron microscopy |
| keywords[4].id | https://openalex.org/keywords/molecular-dynamics |
| keywords[4].score | 0.523200511932373 |
| keywords[4].display_name | Molecular dynamics |
| keywords[5].id | https://openalex.org/keywords/nanotechnology |
| keywords[5].score | 0.5139124393463135 |
| keywords[5].display_name | Nanotechnology |
| keywords[6].id | https://openalex.org/keywords/particle |
| keywords[6].score | 0.4959200322628021 |
| keywords[6].display_name | Particle (ecology) |
| keywords[7].id | https://openalex.org/keywords/chemistry |
| keywords[7].score | 0.1672351360321045 |
| keywords[7].display_name | Chemistry |
| keywords[8].id | https://openalex.org/keywords/computational-chemistry |
| keywords[8].score | 0.08944979310035706 |
| keywords[8].display_name | Computational chemistry |
| language | en |
| locations[0].id | doi:10.1002/marc.202400589 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S130615878 |
| locations[0].source.issn | 1022-1336, 1521-3927 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1022-1336 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Macromolecular Rapid Communications |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Macromolecular Rapid Communications |
| locations[0].landing_page_url | https://doi.org/10.1002/marc.202400589 |
| locations[1].id | pmid:39264522 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Macromolecular rapid communications |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39264522 |
| locations[2].id | pmh:oai:escholarship.org:ark:/13030/qt0kf312br |
| locations[2].is_oa | False |
| locations[2].source | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Macromolecular Rapid Communications, vol 46, iss 1 |
| locations[2].landing_page_url | https://escholarship.org/uc/item/0kf312br |
| locations[3].id | pmh:oai:osti.gov:2440913 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306402487 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) |
| locations[3].source.host_organization | https://openalex.org/I139351228 |
| locations[3].source.host_organization_name | Office of Scientific and Technical Information |
| locations[3].source.host_organization_lineage | https://openalex.org/I139351228 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.osti.gov/biblio/2440913 |
| locations[4].id | pmh:oai:osti.gov:2462734 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306402487 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) |
| locations[4].source.host_organization | https://openalex.org/I139351228 |
| locations[4].source.host_organization_name | Office of Scientific and Technical Information |
| locations[4].source.host_organization_lineage | https://openalex.org/I139351228 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | https://www.osti.gov/biblio/2462734 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5033057776 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1591-7466 |
| authorships[0].author.display_name | Xubo Luo |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[0].affiliations[0].raw_affiliation_string | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[0].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[0].institutions[0].id | https://openalex.org/I148283060 |
| authorships[0].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Xubo Luo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA, Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[1].author.id | https://openalex.org/A5021584909 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4719-8179 |
| authorships[1].author.display_name | M. Seidler |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I95457486 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[1].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[1].institutions[0].id | https://openalex.org/I148283060 |
| authorships[1].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[1].institutions[1].id | https://openalex.org/I95457486 |
| authorships[1].institutions[1].ror | https://ror.org/01an7q238 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I95457486 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | University of California, Berkeley |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Morgan Seidler |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA, Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[2].author.id | https://openalex.org/A5083594863 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2699-8676 |
| authorships[2].author.display_name | Yen Jea Lee |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[2].affiliations[0].raw_affiliation_string | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[2].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[2].institutions[0].id | https://openalex.org/I148283060 |
| authorships[2].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yen Jea Lee |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA, Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[3].author.id | https://openalex.org/A5104807013 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Tianyi Yu |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[3].affiliations[0].raw_affiliation_string | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[3].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[3].institutions[0].id | https://openalex.org/I148283060 |
| authorships[3].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Tianyi Yu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA, Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[4].author.id | https://openalex.org/A5024089820 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3055-8860 |
| authorships[4].author.display_name | Ronald N. Zuckermann |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[4].affiliations[0].raw_affiliation_string | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[4].institutions[0].id | https://openalex.org/I148283060 |
| authorships[4].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ronald N. Zuckermann |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[5].author.id | https://openalex.org/A5046800376 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0106-5565 |
| authorships[5].author.display_name | Nitash P. Balsara |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I95457486 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[5].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[5].institutions[0].id | https://openalex.org/I148283060 |
| authorships[5].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[5].institutions[1].id | https://openalex.org/I95457486 |
| authorships[5].institutions[1].ror | https://ror.org/01an7q238 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I95457486 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | University of California, Berkeley |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Nitash P. Balsara |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA, Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[6].author.id | https://openalex.org/A5061093266 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-2288-1975 |
| authorships[6].author.display_name | Brooks A. Abel |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I95457486 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I148283060 |
| authorships[6].affiliations[1].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[6].institutions[0].id | https://openalex.org/I148283060 |
| authorships[6].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[6].institutions[1].id | https://openalex.org/I95457486 |
| authorships[6].institutions[1].ror | https://ror.org/01an7q238 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I95457486 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | University of California, Berkeley |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Brooks A. Abel |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA, Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[7].author.id | https://openalex.org/A5081930385 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-0598-1453 |
| authorships[7].author.display_name | David Prendergast |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[7].affiliations[0].raw_affiliation_string | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[7].institutions[0].id | https://openalex.org/I148283060 |
| authorships[7].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | David Prendergast |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[8].author.id | https://openalex.org/A5019768395 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Xi Jiang |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I148283060 |
| authorships[8].affiliations[0].raw_affiliation_string | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| authorships[8].institutions[0].id | https://openalex.org/I148283060 |
| authorships[8].institutions[0].ror | https://ror.org/02jbv0t02 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I1330989302, https://openalex.org/I148283060, https://openalex.org/I39565521 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Lawrence Berkeley National Laboratory |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Xi Jiang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.osti.gov/biblio/2440913 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Evaluating Cryo‐TEM Reconstruction Accuracy of Self‐Assembled Polymer Nanostructures |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10857 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994999766349792 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1315 |
| primary_topic.subfield.display_name | Structural Biology |
| primary_topic.display_name | Advanced Electron Microscopy Techniques and Applications |
| related_works | https://openalex.org/W2531643796, https://openalex.org/W1996879913, https://openalex.org/W2114373712, https://openalex.org/W2042233828, https://openalex.org/W2072310787, https://openalex.org/W3044510892, https://openalex.org/W1991678174, https://openalex.org/W2243727187, https://openalex.org/W1986543017, https://openalex.org/W77342359 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | pmh:oai:osti.gov:2440913 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402487 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) |
| best_oa_location.source.host_organization | https://openalex.org/I139351228 |
| best_oa_location.source.host_organization_name | Office of Scientific and Technical Information |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I139351228 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://www.osti.gov/biblio/2440913 |
| primary_location.id | doi:10.1002/marc.202400589 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S130615878 |
| primary_location.source.issn | 1022-1336, 1521-3927 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1022-1336 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Macromolecular Rapid Communications |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Macromolecular Rapid Communications |
| primary_location.landing_page_url | https://doi.org/10.1002/marc.202400589 |
| publication_date | 2024-09-12 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4212814362, https://openalex.org/W2075370047, https://openalex.org/W2000291025, https://openalex.org/W1998840138, https://openalex.org/W2066697261, https://openalex.org/W2010328894, https://openalex.org/W2057607610, https://openalex.org/W2021181435, https://openalex.org/W2621982759, https://openalex.org/W2040927196, https://openalex.org/W2095966980, https://openalex.org/W1965139318, https://openalex.org/W1998407850, https://openalex.org/W3006386971, https://openalex.org/W2938571433, https://openalex.org/W2290289381, https://openalex.org/W2034693925, https://openalex.org/W2019060205, https://openalex.org/W2059397441, https://openalex.org/W2118147816, https://openalex.org/W2092303653, https://openalex.org/W1988448289, https://openalex.org/W2011095551, https://openalex.org/W1992829362, https://openalex.org/W4284890632, https://openalex.org/W1984195387, https://openalex.org/W2057901960, https://openalex.org/W2141158534, https://openalex.org/W2009803833, https://openalex.org/W2103972113, https://openalex.org/W2005601437, https://openalex.org/W2048473576, https://openalex.org/W1986126636, https://openalex.org/W2117274978, https://openalex.org/W2028636490, https://openalex.org/W2912325502, https://openalex.org/W2977361915, https://openalex.org/W2075115399, https://openalex.org/W2101308785, https://openalex.org/W2132294415, https://openalex.org/W2043821105, https://openalex.org/W2129906827, https://openalex.org/W2903714836, https://openalex.org/W2101071020, https://openalex.org/W4210911787, https://openalex.org/W1492556495, https://openalex.org/W575681570, https://openalex.org/W2780078877, https://openalex.org/W3093646295, https://openalex.org/W3046186514, https://openalex.org/W4294637036, https://openalex.org/W3204128622, https://openalex.org/W4321610279, https://openalex.org/W2893788024, https://openalex.org/W2945013162, https://openalex.org/W2587625522, https://openalex.org/W2919834097, https://openalex.org/W4392796087, https://openalex.org/W2910505072, https://openalex.org/W2164659462, https://openalex.org/W3013674006, https://openalex.org/W4376126459, https://openalex.org/W2132629607, https://openalex.org/W2783506271, https://openalex.org/W4399118939, https://openalex.org/W2070753604, https://openalex.org/W2944095474, https://openalex.org/W1031578623, https://openalex.org/W2021546446, https://openalex.org/W2032698311, https://openalex.org/W2021703585, https://openalex.org/W3202179996 |
| referenced_works_count | 72 |
| abstract_inverted_index.a | 136 |
| abstract_inverted_index.2D | 75 |
| abstract_inverted_index.3D | 63 |
| abstract_inverted_index.By | 85 |
| abstract_inverted_index.In | 42 |
| abstract_inverted_index.ab | 77 |
| abstract_inverted_index.an | 13 |
| abstract_inverted_index.as | 135 |
| abstract_inverted_index.by | 29 |
| abstract_inverted_index.in | 123 |
| abstract_inverted_index.is | 12, 55, 97, 112 |
| abstract_inverted_index.of | 23, 39, 47, 61, 65, 94, 106, 119, 143 |
| abstract_inverted_index.on | 109 |
| abstract_inverted_index.to | 35, 57 |
| abstract_inverted_index.and | 52, 80, 103, 129, 146 |
| abstract_inverted_index.are | 83, 101 |
| abstract_inverted_index.due | 34 |
| abstract_inverted_index.for | 17, 139 |
| abstract_inverted_index.its | 133 |
| abstract_inverted_index.the | 21, 40, 45, 59, 87, 92, 104, 110, 117 |
| abstract_inverted_index.(MD) | 50 |
| abstract_inverted_index.soft | 18, 147 |
| abstract_inverted_index.this | 43 |
| abstract_inverted_index.tool | 138 |
| abstract_inverted_index.with | 7, 89 |
| abstract_inverted_index.(SPA) | 11 |
| abstract_inverted_index.These | 114 |
| abstract_inverted_index.Using | 70 |
| abstract_inverted_index.image | 53, 73 |
| abstract_inverted_index.those | 27 |
| abstract_inverted_index.atomic | 90 |
| abstract_inverted_index.fibril | 68 |
| abstract_inverted_index.formed | 28 |
| abstract_inverted_index.initio | 78 |
| abstract_inverted_index.single | 8, 120 |
| abstract_inverted_index.study, | 44 |
| abstract_inverted_index.complex | 126 |
| abstract_inverted_index.confirm | 116 |
| abstract_inverted_index.details | 96 |
| abstract_inverted_index.imaging | 15 |
| abstract_inverted_index.models, | 91 |
| abstract_inverted_index.packing | 37 |
| abstract_inverted_index.remains | 32 |
| abstract_inverted_index.results | 88 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.accuracy | 22, 60 |
| abstract_inverted_index.analysis | 10, 122, 142 |
| abstract_inverted_index.approach | 16 |
| abstract_inverted_index.combined | 6 |
| abstract_inverted_index.detailed | 140 |
| abstract_inverted_index.dynamics | 49 |
| abstract_inverted_index.electron | 3 |
| abstract_inverted_index.emerging | 14 |
| abstract_inverted_index.fidelity | 118 |
| abstract_inverted_index.findings | 115 |
| abstract_inverted_index.location | 108 |
| abstract_inverted_index.particle | 9, 121 |
| abstract_inverted_index.polymers | 145 |
| abstract_inverted_index.recovery | 93 |
| abstract_inverted_index.utilized | 56 |
| abstract_inverted_index.validate | 58 |
| abstract_inverted_index.valuable | 137 |
| abstract_inverted_index.CryoSPARC | 71 |
| abstract_inverted_index.Cryogenic | 1 |
| abstract_inverted_index.assessed, | 98 |
| abstract_inverted_index.comparing | 86 |
| abstract_inverted_index.influence | 105 |
| abstract_inverted_index.molecular | 48, 95 |
| abstract_inverted_index.polymers, | 31 |
| abstract_inverted_index.potential | 36, 134 |
| abstract_inverted_index.resolving | 125 |
| abstract_inverted_index.software, | 72 |
| abstract_inverted_index.synthetic | 30, 144 |
| abstract_inverted_index.uncertain | 33 |
| abstract_inverted_index.accurately | 124 |
| abstract_inverted_index.cryo‐TEM | 62 |
| abstract_inverted_index.evaluated. | 113 |
| abstract_inverted_index.exhibiting | 132 |
| abstract_inverted_index.extraction | 107 |
| abstract_inverted_index.homogenous | 81 |
| abstract_inverted_index.materials. | 19, 148 |
| abstract_inverted_index.microscopy | 4 |
| abstract_inverted_index.performed. | 84 |
| abstract_inverted_index.structural | 127, 141 |
| abstract_inverted_index.structures | 100 |
| abstract_inverted_index.combination | 46 |
| abstract_inverted_index.identified, | 102 |
| abstract_inverted_index.polypeptoid | 67 |
| abstract_inverted_index.refinements | 82 |
| abstract_inverted_index.simulations | 51, 54 |
| abstract_inverted_index.structures, | 131 |
| abstract_inverted_index.(cryo‐TEM) | 5 |
| abstract_inverted_index.particularly | 26 |
| abstract_inverted_index.simulations, | 74 |
| abstract_inverted_index.transmission | 2 |
| abstract_inverted_index.heterogeneity | 38 |
| abstract_inverted_index.heterogeneous | 99, 130 |
| abstract_inverted_index.characteristics | 128 |
| abstract_inverted_index.nanostructures, | 25 |
| abstract_inverted_index.nanostructures. | 41, 69 |
| abstract_inverted_index.reconstructions | 64, 111 |
| abstract_inverted_index.classifications, | 76 |
| abstract_inverted_index.reconstructions, | 79 |
| abstract_inverted_index.self‐assembled | 66 |
| abstract_inverted_index.SPA‐reconstructed | 24 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.81339353 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |