Evaluating Current and Emergent JAK Inhibitors for Alopecia Areata: A Narrative Review Article Swipe
Katherine Sanchez
,
Hanna Englander
,
Lana Salloum
,
Samantha Gregoire
,
Ursula Biba
,
Sherry Ershadi
,
Arash Mostaghimi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s13555-025-01517-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s13555-025-01517-9
Alopecia areata (AA) is an autoimmune condition characterized by non-scarring hair loss on the scalp, face, and body, affecting approximately 2% of the global population. Current treatments, including topical corticosteroids, topical immunotherapies, and systemic immunosuppressants, often demonstrate inconsistent efficacy and raise concerns about long-term safety, emphasizing the need for safer and more effective therapies. Janus kinase (JAK) inhibitors have emerged as a promising treatment option, offering a targeted approach by addressing the immune-mediated mechanisms driving hair follicle destruction in AA. Recent clinical advances have led to FDA approval of three JAK inhibitors-baricitinib, ritlecitinib, and deuruxolitinib-based on pivotal trials showing significant hair regrowth. Baricitinib has demonstrated durable efficacy, with 35-40% of patients achieving a Severity of Alopecia Tool (SALT) score ≤ 20 at 36 weeks. Ritlecitinib similarly reported 23% of patients achieving a SALT score ≤ 20 at week 24. Deuruxolitinib has also shown efficacy with 31% of patients achieving a SALT score ≤ 20 at 24 weeks. Off-label use of JAK inhibitors like tofacitinib and ruxolitinib have also demonstrated efficacy in limited studies. This review aims to consolidate and summarize the latest clinical evidence and trial data on JAK inhibitors for AA, providing an up-to-date resource for clinicians and researchers to guide evidence-based management and optimize therapeutic outcomes.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1007/s13555-025-01517-9
- https://link.springer.com/content/pdf/10.1007/s13555-025-01517-9.pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4413106595Canonical identifier for this work in OpenAlex
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https://doi.org/10.1007/s13555-025-01517-9Digital Object Identifier
- Title
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Evaluating Current and Emergent JAK Inhibitors for Alopecia Areata: A Narrative ReviewWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-12Full publication date if available
- Authors
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Katherine Sanchez, Hanna Englander, Lana Salloum, Samantha Gregoire, Ursula Biba, Sherry Ershadi, Arash MostaghimiList of authors in order
- Landing page
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https://doi.org/10.1007/s13555-025-01517-9Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s13555-025-01517-9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s13555-025-01517-9.pdfDirect OA link when available
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Alopecia areata, Current (fluid), Dermatology, Narrative, Narrative review, Medicine, Intensive care medicine, Engineering, Art, Literature, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
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