Evaluating Plasma and Brain TRPV1 Channels in the Animal Model of Episodic and Chronic Migraine: The Possible Role of Somatosensory Cortex TRPV1 in Migraine Transformation Article Swipe
Fariba Karimzadeh
,
Fahime Zavvari
,
Atousa Janzadeh
,
Negin Mojarad
,
Zeinab Ghorbani
,
Mansoureh Togha
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5812/ans.115709
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.5812/ans.115709
Background: Despite extensive research, the exact molecular mechanisms underlying migraine development and especially its progression and transformation from episodic into chronic is still unknown. Objectives: This study aimed to assess the role of somatosensory cortex and hippocampal transient receptor potential vanilloid 1 (TRPV1) in migraine in a rat model. Methods: This study was an intervention study. Adult male Wistar rats were divided into three groups, including sham, episodic migraine (EM), and chronic migraine (CM). The sham group received normal intraperitoneal (IP) saline injections every two days for 11 days, and the EM group received a single dose of trinitroglycerin (TNG) injection (IP; 10 mg/kg). For the CM group, TNG was administrated every two days (on days 3, 5, 7, 9, and 11; IP; 10 mg/kg). TRPV1 levels in plasma, somatosensory cortex, and hippocampus were detected with an enzyme-linked immunosorbent assay (ELISA) kit. Results: The findings showed that in both CM and EM groups the TRPV1 levels in plasma (P < 0.001 in both groups), somatosensory cortex (P < 0.05 and P < 0.001, respectively), and hippocampus (P < 0.01 in both groups) increased after migraine induction. Interestingly, in the somatosensory cortex, this TRPV1 elevation in the CM group was much greater than the EM group, and a significant difference was observed between the two groups (P < 0.05). Conclusions: Our results suggested that headache severity and frequency may enhance concomitant with the upregulation of somatosensory cortex TRPV1. This new achievement can help to develop new drug approaches to prevent CM.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5812/ans.115709
- https://brieflands.com/articles/ans-115709.pdf
- OA Status
- diamond
- Cited By
- 8
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280639009
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4280639009Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.5812/ans.115709Digital Object Identifier
- Title
-
Evaluating Plasma and Brain TRPV1 Channels in the Animal Model of Episodic and Chronic Migraine: The Possible Role of Somatosensory Cortex TRPV1 in Migraine TransformationWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-01-30Full publication date if available
- Authors
-
Fariba Karimzadeh, Fahime Zavvari, Atousa Janzadeh, Negin Mojarad, Zeinab Ghorbani, Mansoureh ToghaList of authors in order
- Landing page
-
https://doi.org/10.5812/ans.115709Publisher landing page
- PDF URL
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https://brieflands.com/articles/ans-115709.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://brieflands.com/articles/ans-115709.pdfDirect OA link when available
- Concepts
-
TRPV1, Somatosensory system, Migraine, Hippocampus, Medicine, Chronic Migraine, Cortex (anatomy), Hippocampal formation, Endocrinology, Internal medicine, Anesthesia, Neuroscience, Transient receptor potential channel, Psychology, Receptor, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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2023: 8Per-year citation counts (last 5 years)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
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| primary_location.landing_page_url | https://doi.org/10.5812/ans.115709 |
| publication_date | 2022-01-30 |
| publication_year | 2022 |
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