Evaluation of a static mixer as a new microfluidic method for liposome formulation Article Swipe
A. Ota
,
Ayaka Mochizuki
,
Keitaro Sou
,
Shinji Takeoka
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2023.1229829
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2023.1229829
Introduction: Microfluidic formulation of liposomes has been extensively studied as a potential replacement for batch methods, which struggle with problems in scalability and difficulty in modulating conditions. Although microfluidic devices are considered to be able to combat these issues, an adequate replacement method has yet to be established. Methods: This paper examines the potential of a static mixer (SM) by comparing the encapsulation efficiency, loading, lamellarity, and user-friendliness with a commonly used microfluidic device, a staggered herringbone micromixer (SHM). Results: In both devices, it was found that as the initial lipid concentration increased, the particle size increased; however, the overall particle size was seen to be significantly larger in the liposomes prepared with SM. PDI remained significantly smaller in SM, however, signifying that better control of the particle size was accomplished in SM. In addition, the encapsulation efficiency was slightly smaller in SM compared to SHM, and in both devices, the values increased as the initial lipid concentration increased. The increase in encapsulation efficiencies was significantly smaller than that of the theoretical encapsulation efficiency, and this was found to be due to the increase in lamellarity as the initial lipid concentration increased. Discussion: In terms of user-friendliness, SM demonstrated significant advantages. The mixing elements could be taken out from the device, allowing for thorough cleaning of the element and device before and after experiments and ensuring experiments are conducted at virgin state in every round. Consequently, it was found that SM not only can produce uniformly distributed liposomes but has the potential to become a more practical method for liposome formulation with modifications in the mixing elements.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2023.1229829
- OA Status
- gold
- Cited By
- 4
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386072666
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386072666Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fbioe.2023.1229829Digital Object Identifier
- Title
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Evaluation of a static mixer as a new microfluidic method for liposome formulationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-22Full publication date if available
- Authors
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A. Ota, Ayaka Mochizuki, Keitaro Sou, Shinji TakeokaList of authors in order
- Landing page
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https://doi.org/10.3389/fbioe.2023.1229829Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fbioe.2023.1229829Direct OA link when available
- Concepts
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Microfluidics, Liposome, Micromixer, Encapsulation (networking), Materials science, Particle size, Scalability, Nanotechnology, Biomedical engineering, Chromatography, Computer science, Chemistry, Chemical engineering, Engineering, Database, Computer networkTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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