Evaluation of acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets in experimental animals Article Swipe
Trần Thanh Tùng
,
Đậu Thùy Dương
,
Pham Thi Thuy Minh
,
Nguyen Thu Hien
,
Đinh Thị Thu Hằng
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.52852/tcncyh.v141i5.210
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.52852/tcncyh.v141i5.210
The study aimed to evaluate the acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets through oral administration using experimental animal models. Acute toxicity in Swiss mice was determined using the Litchfield Wilcoxon method. The subchronic toxicity in Wistar rats was evaluated according to WHO and OECD’s recommendation with oral doses of 4.68 g/kg/day (equivalent to recommended human dose) and 14.04 g/kg/day (3 times the recommended human dose) for 4 consecutive weeks. In terms of acute toxicity, “Phuong Dong Dai Trang” tablets did not express acute toxicity in mice at the highest dose used (232.14 g materials/kg). In terms of the subchronic toxicity, after oral administration of “Phuong Dong Dai Trang” tablets, hematological parameters, hepato - renal functions, and microscopic images of liver and kidney were unchanged in the treatment group compared to the control group. In conclusion, “Phuong Dong Dai Trang” tablets did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.52852/tcncyh.v141i5.210
- https://tapchinghiencuuyhoc.vn/index.php/tcncyh/article/download/210/134
- OA Status
- bronze
- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3184085684Canonical identifier for this work in OpenAlex
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https://doi.org/10.52852/tcncyh.v141i5.210Digital Object Identifier
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Evaluation of acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets in experimental animalsWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2021Year of publication
- Publication date
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2021-06-30Full publication date if available
- Authors
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Trần Thanh Tùng, Đậu Thùy Dương, Pham Thi Thuy Minh, Nguyen Thu Hien, Đinh Thị Thu HằngList of authors in order
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https://doi.org/10.52852/tcncyh.v141i5.210Publisher landing page
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https://tapchinghiencuuyhoc.vn/index.php/tcncyh/article/download/210/134Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://tapchinghiencuuyhoc.vn/index.php/tcncyh/article/download/210/134Direct OA link when available
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Toxicity, Oral administration, Acute toxicity, Medicine, Pharmacology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Trang” | 14, 81, 111, 142 |
| abstract_inverted_index.Wilcoxon | 33 |
| abstract_inverted_index.compared | 132 |
| abstract_inverted_index.evaluate | 4 |
| abstract_inverted_index.g/kg/day | 54, 62 |
| abstract_inverted_index.tablets, | 112 |
| abstract_inverted_index.toxicity | 24, 37, 87 |
| abstract_inverted_index.according | 43 |
| abstract_inverted_index.evaluated | 42 |
| abstract_inverted_index.toxicity, | 77, 103 |
| abstract_inverted_index.treatment | 130 |
| abstract_inverted_index.unchanged | 127 |
| abstract_inverted_index.“Phuong | 11, 78, 108, 139 |
| abstract_inverted_index.Litchfield | 32 |
| abstract_inverted_index.determined | 29 |
| abstract_inverted_index.functions, | 118 |
| abstract_inverted_index.subchronic | 8, 36, 102, 149 |
| abstract_inverted_index.toxicities | 9, 150 |
| abstract_inverted_index.(equivalent | 55 |
| abstract_inverted_index.conclusion, | 138 |
| abstract_inverted_index.consecutive | 71 |
| abstract_inverted_index.microscopic | 120 |
| abstract_inverted_index.parameters, | 114 |
| abstract_inverted_index.recommended | 57, 66 |
| abstract_inverted_index.experimental | 20 |
| abstract_inverted_index.hematological | 113 |
| abstract_inverted_index.administration | 18, 106 |
| abstract_inverted_index.materials/kg). | 97 |
| abstract_inverted_index.recommendation | 48 |
| cited_by_percentile_year | |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.11880971 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |