Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice Article Swipe
Davi Azevedo Ferreira
,
Anna Beatriz Araujo Medeiros
,
Mariana Mendonça Soares
,
Éssia de Almeida Lima
,
Gabriela Carolina Santos Lima de Oliveira
,
Mateus Bernardo da Silva Leite
,
Matheus Vieira Machado
,
José Augusto Ferreira Perez Villar
,
Leandro A. Barbosa
,
Cristóforo Scavone
,
Marcelo Tigre Moura
,
Sandra Rodrigues‐Mascarenhas
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13181568
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13181568
Cardiotonic steroids are known to bind to Na+/K+-ATPase and regulate several biological processes, including the immune response. The synthetic cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) is emerging as a promising immunomodulatory molecule, although it has remained largely unexplored. Therefore, we tested the immunomodulatory potential of BD-8 both in vitro and in vivo. Hence, primary mouse macrophages were incubated with combinations of BD-8 and the pro-inflammatory fungal protein zymosan (ZYM). Nitric oxide (NO) production was determined by Griess reagent and cytokines production was assessed by enzyme-linked immunosorbent assay. Inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), p-nuclear factor kappa B p65 (NF-κB p65), p-extracellular signal-regulated kinase (p-ERK), and p-p38 were evaluated by flow cytometry. Macrophages exposed to BD-8 displayed reduced phagocytic activity, NO levels, and production of the proinflammatory cytokine IL-1β induced by ZYM. Furthermore, BD-8 diminished the expression of iNOS and phosphorylation of NF-κB p65, ERK, and p38. Additionally, BD-8 exhibited anti-inflammatory capacity in vivo in a carrageenan-induced mouse paw edema model. Taken together, these findings demonstrate the anti-inflammatory activity of BD-8 and further reinforce the potential of cardiotonic steroids and their derivatives as immunomodulatory molecules.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells13181568
- OA Status
- gold
- Cited By
- 7
- References
- 76
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402601144
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402601144Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cells13181568Digital Object Identifier
- Title
-
Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-18Full publication date if available
- Authors
-
Davi Azevedo Ferreira, Anna Beatriz Araujo Medeiros, Mariana Mendonça Soares, Éssia de Almeida Lima, Gabriela Carolina Santos Lima de Oliveira, Mateus Bernardo da Silva Leite, Matheus Vieira Machado, José Augusto Ferreira Perez Villar, Leandro A. Barbosa, Cristóforo Scavone, Marcelo Tigre Moura, Sandra Rodrigues‐MascarenhasList of authors in order
- Landing page
-
https://doi.org/10.3390/cells13181568Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/cells13181568Direct OA link when available
- Concepts
-
Proinflammatory cytokine, Pharmacology, Nitric oxide, Chemistry, Nitric oxide synthase, Reactive oxygen species, p38 mitogen-activated protein kinases, Zymosan, In vivo, Immune system, MAPK/ERK pathway, Cytokine, Inflammation, Biochemistry, In vitro, Immunology, Kinase, Biology, Organic chemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7Per-year citation counts (last 5 years)
- References (count)
-
76Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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