Evaluation of Celiac Disease in Children with Dilated Cardiomyopathy Article Swipe
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· 2017
· Open Access
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· OA: W2581526475
Background: The incidence of Celiac Disease (CD) raises in children with Dilated \nCardiomyopathy (DCM). \nObjectives: This study aimed to investigate the prevalence of CD in children with DCM \ncompared with controls. \nPatients and Methods: This case-control study was conducted on 38 patients with DCM \nand 76 healthy controls to evaluate tTG and IgA during 2013 - 2014. Echocardiography \nwas performed for all patients to detect cardiomyopathy. The exclusion criteria were \nIgA deficiency, history of digestive, endocrine, and metabolic disorders, iron deficiency, \nkidney disease, fever, and chronic diseases. Samples were centrifuged and the separated \nsera were kept at -70°C until tTG IgA and total IgA were measured by ELISA kit. After \nall, the data were entered into the SPSS statistical software, version 20 and were analyzed \nusing parametric and non-parametric tests. Significance level was set at P < 0.05. \nResults: This study was performed on 114 children; 38 in the case and 76 in the control \ngroup. The results showed no significant difference between the two groups regarding \nthe means of continuous variables, including sex, tTG status, and diseases. From the 38 \npatients in the case group, 31 ones (81.58%) had normal tTG (≤ 20) and 7 ones (18.42%) \nhad abnormal tTG (≥ 20). However, 72 participants in the control group (94.74%) showed \nnormal tTG status (≥ 20). The results showed a significant difference between the two \ngroups regarding tTG status (chi-square = 5.031, P = 0.025). \nConclusions: The results revealed a positive association between CD and DCM regardless \nof serology- or pathology-based diagnostic tools. This suggests the need for increasing \nawareness of patients with DCM regarding CD.
