Evaluation of deslorelin implant on subsequent mammary tumors of rats (Rattus norvegicus) Article Swipe
Claire Vergneau‐Grosset
,
L. Peña
,
Caroline Cluzel
,
Michelle G. Hawkins
,
Édouard Maccolini
,
K. Sinclair
,
Jennifer E. Graham
,
Miranda J. Sadar
,
David Sánchez-Migallón Guzmán
,
Stéphane Lair
,
Isabelle Langlois
,
Joanne Paul‐Murphy
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1053/j.jepm.2019.08.001
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1053/j.jepm.2019.08.001
Mammary fibroadenomas are one of the most common tumors of female companion rats (Rattus norvegicus forma domestica). The objectives of this study were to determine if subcutaneous administration of a deslorelin implant following excision of fibroadenomas can prevent or delay development of additional mammary tumors and increase survival in companion rats. Female intact client-owned rats with benign mammary tumors were divided into three groups: no implant (n = 10), placebo implant (n = 10), or 4.7 mg deslorelin implant (n = 10) placed within 2 months of tumor excision. Rats were monitored for subsequent mammary tumors for 10 months following treatment. Expression of estrogen α, progesterone, prolactin, and androgen receptors stained by immunohistochemistry in primary masses of rats included in the deslorelin-treated group was evaluated using the Allred scoring system. In the control non-implanted group, four of the 10 rats developed another mammary tumor, including one anaplastic carcinoma. In the control placebo group, five of the 10 rats developed another mammary tumor, including one ductal carcinoma. In the deslorelin-treated group, three of 10 rats developed another mammary tumor, including one adenocarcinoma. Median time between surgery and new mass detection did not differ significantly among groups (55 days in the deslorelin group vs. 77 days in the control placebo group, P = 0.25). Median survival times after surgery did not differ significantly among groups. No correlation was noted between receptor expression and response to treatment with deslorelin. Deslorelin implants placed within 2 months of benign mammary tumor surgical excision were not associated with a decreased risk of developing subsequent mammary tumors, nor with an increased survival in female rats. Further studies are needed to define useful adjunct therapy to surgery.
Related Topics
Concepts
Medicine
Implant
Mammary tumor
Immunohistochemistry
Placebo
Mammary gland
Prolactin
Estrogen receptor
Internal medicine
Hormone
Urology
Endocrinology
Pathology
Surgery
Cancer
Breast cancer
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1053/j.jepm.2019.08.001
- OA Status
- hybrid
- Cited By
- 3
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2965134915
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2965134915Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1053/j.jepm.2019.08.001Digital Object Identifier
- Title
-
Evaluation of deslorelin implant on subsequent mammary tumors of rats (Rattus norvegicus)Work title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-08-06Full publication date if available
- Authors
-
Claire Vergneau‐Grosset, L. Peña, Caroline Cluzel, Michelle G. Hawkins, Édouard Maccolini, K. Sinclair, Jennifer E. Graham, Miranda J. Sadar, David Sánchez-Migallón Guzmán, Stéphane Lair, Isabelle Langlois, Joanne Paul‐MurphyList of authors in order
- Landing page
-
https://doi.org/10.1053/j.jepm.2019.08.001Publisher landing page
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://doi.org/10.1053/j.jepm.2019.08.001Direct OA link when available
- Concepts
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Medicine, Implant, Mammary tumor, Immunohistochemistry, Placebo, Mammary gland, Prolactin, Estrogen receptor, Internal medicine, Hormone, Urology, Endocrinology, Pathology, Surgery, Cancer, Breast cancer, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2021: 2, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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