Evaluation of MDR1 and MRPA genes expression in different types of dry cutaneous leishmaniasis Article Swipe
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· 2019
· Open Access
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· DOI: https://doi.org/10.1186/s13104-019-4784-0
Objective The resistance to antimony-containing glucantime is a major obstacle to successful treatment, especially in endemic areas. Looking the molecular mechanisms involved in this drug resistance will help in choosing the best treatment. The aim of this study was to evaluate the expression of multidrug-resistance 1 (MDR1) and multidrug-resistance protein A (MRPA) genes in acute, chronic non-lupoid, and chronic lupoid forms of dry type cutaneous leishmaniasis (DTCL). Results MDR1 gene was over-expressed as 14.4- and 1.56-folds in the chronic lupoid and acute forms compared with the chronic non-lupoid form, respectively. Results comparison showed P < 0.05 between the chronic non-lupoid and acute groups, P < 0.01 between acute and chronic lupoid groups, and P < 0.001 between the chronic non-lupoid and chronic lupoid groups. MRPA gene was over-expressed as 266 and 17.7-fold in the chronic lupoid and chronic non-lupoid forms compared with the acute form, respectively. Statistical analysis showed P < 0.01 between the chronic non-lupoid and chronic lupoid groups, P < 0.05 between acute and chronic non-lupoid groups, and P < 0.001 between the acute and chronic lupoid groups.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13104-019-4784-0
- https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/s13104-019-4784-0
- OA Status
- gold
- Cited By
- 8
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2994864336
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2994864336Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s13104-019-4784-0Digital Object Identifier
- Title
-
Evaluation of MDR1 and MRPA genes expression in different types of dry cutaneous leishmaniasisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-12-01Full publication date if available
- Authors
-
Maryam Fekri-SoofiAbadi, Meisam Fekri, Alireza Moradabadi, Reza Vahidi, Morteza Khaleghi, Maryam Ram, Shahriar DabiriList of authors in order
- Landing page
-
https://doi.org/10.1186/s13104-019-4784-0Publisher landing page
- PDF URL
-
https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/s13104-019-4784-0Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/s13104-019-4784-0Direct OA link when available
- Concepts
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Gene, Cutaneous leishmaniasis, Leishmaniasis, Biology, Leishmania, Computational biology, Expression (computer science), Gene expression, Genetics, Immunology, Bioinformatics, Medicine, Computer science, Parasite hosting, World Wide Web, Programming languageTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 1, 2022: 2, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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