Evaluation Of Renal Biomarkers During Coronavirus-2 Infection Of Severe Acute Respiratory Syndrome Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.58489/2836-3604/014
· OA: W4405732615
Introduction : In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. It quickly spread to other parts of the world. Advances in the field of pathophysiology have shown that co-expression of angiotensin-converting enzyme 2 (ACE 2) receptors and TMPRSS proteases are required for virus entry into the host cell. Direct renal involvement of the virus was therefore strongly suspected due to the high concentration of these receptors at the renal level, particularly at the level of the proximal tubule. Materials and Method : This was a prospective, descriptive and analytical study of patients infected with SARS-CoV2. For each patient, blood samples were taken on a heparin tube or dry tube for the determination of parameters (albumin, creatinine, urea, Na+ K+) with the Abbott ARCHITECT ci4100. Results : Our study population consisted of 153 subjects with covid-19. The mean age was 55±19 years (15 and 93 years). The most representative age group was patients over 60 years of age (52.3%). Male sex accounted for 53.8% of the study population. 45.1% of patients had a severe form with 16.3% of deaths during hospitalization. The association of renal biomarkers with disease severity showed that the risk of severe disease was higher in patients with hypoalbuminemia (OR=5.3 ; p=0.001), hyperuraemia (OR=4.1; p=0.001), hypercreatinine (OR=3.6; p=0.001), hyponatremia (OR=2.8; p=0.008) and hyperkalemia (OR=2.7; p=0.003). Conclusion: Disruptions of renal biomarkers during SARS-Cov2 infection increase the risk of severity and mortality. Our study suggests that clinicians should pay close attention to kidney biomarkers in hospitalized patients with COVID-19.
