Evaluation of the Antinociceptive, Antiallodynic, Antihyperalgesic and Anti-Inflammatory Effect of Polyalthic Acid Article Swipe
Juan Rodríguez‐Silverio
,
María Elena Sánchez‐Mendoza
,
Héctor Isaac Rocha‐González
,
Gerardo Reyes‐García
,
Francisco Javier Flores‐Murrieta
,
Yaraset López‐Lorenzo
,
Geovanna Nallely Quiñonez‐Bastidas
,
Jesús Arrieta
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26102921
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26102921
Nonsteroidal anti-inflammatory drugs (NSAIDs) are very commonly used, but their adverse effects warrant investigating new therapeutic alternatives. Polyalthic acid, a labdane-type diterpenoid, is known to produce gastroprotection, tracheal smooth muscle relaxation, and antitumoral, antiparasitic and antibacterial activity. This study aimed to evaluate the antinociceptive, antiallodynic, antihyperalgesic and anti-inflammatory effect of polyalthic acid on rats. Moreover, the effectiveness of treating hyperalgesia with a combination of polyalthic acid and naproxen was analyzed, as well as the type of drug–drug interaction involved. Nociception was examined by injecting 1% formalin into the right hind paw and thermal hyperalgesia and inflammation by injecting a 1% carrageenan solution into the left hind paw of rats. Allodynia was assessed on an L5/L6 spinal nerve ligation model. Polyalthic acid generated significant antinociceptive (56–320 mg/kg), antiallodynic (100–562 mg/kg), and antihyperalgesic and anti-inflammatory (10–178 mg/kg) effects. Antinociception mechanisms were explored by pretreating the rats with naltrexone, ODQ and methiothepin, finding the effect blocked by the former two compounds, which indicates the participation of opioid receptors and guanylate cyclase. An isobolographic analysis suggests synergism between polyalthic acid and naproxen in the combined treatment of hyperalgesia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules26102921
- https://www.mdpi.com/1420-3049/26/10/2921/pdf?version=1620989119
- OA Status
- gold
- Cited By
- 11
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3162751123
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3162751123Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules26102921Digital Object Identifier
- Title
-
Evaluation of the Antinociceptive, Antiallodynic, Antihyperalgesic and Anti-Inflammatory Effect of Polyalthic AcidWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-14Full publication date if available
- Authors
-
Juan Rodríguez‐Silverio, María Elena Sánchez‐Mendoza, Héctor Isaac Rocha‐González, Gerardo Reyes‐García, Francisco Javier Flores‐Murrieta, Yaraset López‐Lorenzo, Geovanna Nallely Quiñonez‐Bastidas, Jesús ArrietaList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules26102921Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/26/10/2921/pdf?version=1620989119Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/26/10/2921/pdf?version=1620989119Direct OA link when available
- Concepts
-
Pharmacology, Nociception, Hyperalgesia, Chemistry, Opioid, Naproxen, Medicine, Receptor, Biochemistry, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 4, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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