Evaluation of the Synergistic Antimicrobial activity of Amikacin with Norfloxacin against Pseudomonas aeruginosa isolated from buffaloes clinical mastitis Article Swipe
Hanaa M. Abdelkhalek
,
Hanaa M. Abdelkhalek
,
Hanan Nagib
,
Randa Elias
,
Saad Mansour
,
Walid Mousa
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2235241/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2235241/v1
Mastitis is a serious and economically problem commonly prevalent in most dairy cattle and buffaloes herds. Pseudomonas aeruginosa ( P. aeruginosa) is opportunistic pathogens implicated in veterinary disorders including clinical mastitis in buffaloes. This study aimed to investigate the antibiogram pattern and synergistic effect of amikacin and norfloxacin against resistant P. aeruginosa isolates from mastitis origin. In addition, detection of some virulence and antibiotics resistance genes. Out of two hundred buffaloes, sixty (30%) were diagnosed as clinical mastitis according to inflammatory signs and the culture results reveled only 5 (8.3%) were P.aeruginosa . Most of P. aeruginosa exhibited resistance to most antimicrobials classes. Meanwhile, the minimal inhibitory concentration (MIC) for amikacin and norfloxacin is significantly reduced from 64 µg/mL to 1 µg/mL and from 256 µg/mL to 8µg/mL respectively with frictional inhibitory concentration (FIC) index 0.25. Therefore, the FIC index recognized a synergistic activity between amikacin and norfloxacin against all P.areuginosa isolates. The mPCR proved to be an efficient tool for detection of virulence genes ( exo T, tox A, opr L, and isa I) at 152, 396, 504, 606 bp respectively. In addition, all the P.aeruginosa were found to carry the resistance genes ( qnr S, qnr A, aad B). In conclusion, the combination of norfloxacin plus amikacin suppressed the resistance pattern P. aeruginosa isolates. Therefore, their combination showed synergistic bacterial potential antimicrobial activity in treatment of mastitis due to P. aeruginosa infection and help in reducing the resistance problem.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2235241/v1
- https://www.researchsquare.com/article/rs-2235241/latest.pdf
- OA Status
- green
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313458725
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4313458725Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-2235241/v1Digital Object Identifier
- Title
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Evaluation of the Synergistic Antimicrobial activity of Amikacin with Norfloxacin against Pseudomonas aeruginosa isolated from buffaloes clinical mastitisWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-03Full publication date if available
- Authors
-
Hanaa M. Abdelkhalek, Hanaa M. Abdelkhalek, Hanan Nagib, Randa Elias, Saad Mansour, Walid MousaList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2235241/v1Publisher landing page
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https://www.researchsquare.com/article/rs-2235241/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-2235241/latest.pdfDirect OA link when available
- Concepts
-
Norfloxacin, Amikacin, Pseudomonas aeruginosa, Antimicrobial, Microbiology, Mastitis, Antibiotics, Medicine, Biology, Ciprofloxacin, Bacteria, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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