Evaluation of the Toxicity Effects of Polyethyleneimine (Pei) on Cell Viability and Morphology of VSMC Cells Article Swipe
Fahimeh Zamani‐Garmsiri
,
Mohammad Najafi
,
Asghar Mohammadi
,
Farhad Shaikhnia
,
Ghasem Ghasempour
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.32598/qums.15.6.2353.1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.32598/qums.15.6.2353.1
Background and Objectives: Today, PEI is used for high-efficiency gene transfection. This polycation can have toxic effects on cells due to charged amine groups. This study evaluated the toxic effects of PEI in both single and oligonucleotide-binding modes on VSMC cells. Methods: First, VSMC cells were cultured and then transfected by nanoparticles in two PEI states alone and containing oligonucleotides. After 24 hours, cell viability and morphology were assessed using MTT and electron microscopy methods respectively. Data were analysed using the one-way ANOVA, followed by the Tukey Post-Hoc test. Results: The results showed that nanoparticles significantly reduced the cell viability by causing toxicity to cells (P<0.0001) and also its images showed cell death and apoptosis. But PEI containing oligonucleotides had no toxic effects on cell viability (P= 0.7414). Its electron microscope image also showed a normal cell morphology. Conclusion: Overall, this study showed that the effect of PEI toxicity on VSMC cells is inhibited by oligonucleotide sequencing and thus neutralizing the positive charges of the amine group.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.32598/qums.15.6.2353.1
- OA Status
- diamond
- Related Works
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- OpenAlex ID
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https://openalex.org/W4210362606Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.32598/qums.15.6.2353.1Digital Object Identifier
- Title
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Evaluation of the Toxicity Effects of Polyethyleneimine (Pei) on Cell Viability and Morphology of VSMC CellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2021Year of publication
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2021-09-01Full publication date if available
- Authors
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Fahimeh Zamani‐Garmsiri, Mohammad Najafi, Asghar Mohammadi, Farhad Shaikhnia, Ghasem GhasempourList of authors in order
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https://doi.org/10.32598/qums.15.6.2353.1Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.32598/qums.15.6.2353.1Direct OA link when available
- Concepts
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Viability assay, Transfection, Apoptosis, Toxicity, Oligonucleotide, MTT assay, Molecular biology, Cell, Chemistry, Cell growth, Biology, Pharmacology, Cell biology, Biochemistry, Gene, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| primary_location.source.host_organization_lineage_names | Qom University of Medical Sciences |
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| primary_location.raw_source_name | Qom Univ Med Sci J |
| primary_location.landing_page_url | https://doi.org/10.32598/qums.15.6.2353.1 |
| publication_date | 2021-09-01 |
| publication_year | 2021 |
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