Evaluation of the Xpert HCV Viral Load Finger-Stick Point-of-Care Assay Article Swipe
F. Lamoury
,
Sahar Bajis
,
Behzad Hajarizadeh
,
Alison D. Marshall
,
Marianne Martinello
,
Elena Ivanova
,
Beth Catlett
,
Yasmin Mowat
,
Philippa Marks
,
Janaki Amin
,
Julie Smith
,
Nadine Ezard
,
Victoria Cock
,
Jeremy Hayllar
,
David H. Persing
,
Marika Kleman
,
Philip Cunningham
,
Gregory J. Dore
,
Tanya Applegate
,
Jason Grebely
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiy114
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiy114
Point-of-care hepatitis C virus (HCV) RNA testing is advantageous, enabling diagnosis of active infection in a single visit. This study evaluated the sensitivity and specificity of the Xpert HCV Viral Load Finger-Stick assay (Xpert HCV VL FS) for HCV RNA detection (finger-stick) and the Xpert HCV Viral Load assay (plasma) compared with the Abbott RealTime HCV Viral Load assay by venepuncture. Plasma and finger-stick capillary whole-blood samples were collected from participants in an observational cohort in Australia. Of 223 participants enrolled, HCV RNA was detected in 40% of participants (85 of 210) with available Xpert HCV Viral Load testing. Participants receiving HCV therapy were excluded from subsequent analyses (n = 16). Sensitivity of the Xpert HCV Viral Load assay for HCV RNA quantification in plasma collected by venepuncture was 100.0% (95% confidence interval [CI] 96.9%-100.0%) and specificity was 100.0% (95% CI, 94.4%-100.0%). Sensitivity of the Xpert HCV VL FS assay for HCV RNA quantification in samples collected by finger-stick was 100.0% (95% CI, 93.9%-100.0%) and specificity was 100.0% (95% CI, 96.6%-100.0%). The Xpert HCV VL FS test can accurately detect active infection from a finger-stick sample in 1 hour allowing single-visit HCV diagnosis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/infdis/jiy114
- https://academic.oup.com/jid/article-pdf/217/12/1889/24862761/jiy114.pdf
- OA Status
- bronze
- Cited By
- 116
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2789574679
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2789574679Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/infdis/jiy114Digital Object Identifier
- Title
-
Evaluation of the Xpert HCV Viral Load Finger-Stick Point-of-Care AssayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-02-27Full publication date if available
- Authors
-
F. Lamoury, Sahar Bajis, Behzad Hajarizadeh, Alison D. Marshall, Marianne Martinello, Elena Ivanova, Beth Catlett, Yasmin Mowat, Philippa Marks, Janaki Amin, Julie Smith, Nadine Ezard, Victoria Cock, Jeremy Hayllar, David H. Persing, Marika Kleman, Philip Cunningham, Gregory J. Dore, Tanya Applegate, Jason GrebelyList of authors in order
- Landing page
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https://doi.org/10.1093/infdis/jiy114Publisher landing page
- PDF URL
-
https://academic.oup.com/jid/article-pdf/217/12/1889/24862761/jiy114.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/jid/article-pdf/217/12/1889/24862761/jiy114.pdfDirect OA link when available
- Concepts
-
Medicine, Venipuncture, Viral load, Hepatitis C virus, Point-of-care testing, Virology, Point of care, Hepacivirus, Hepatitis C, Internal medicine, Immunology, Virus, Pathology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
116Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 17, 2023: 15, 2022: 10, 2021: 20Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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