Event‐related potential signatures of episodic memory decline predicting progression to Alzheimer’s disease in asymptomatic at‐risk subjects: a longitudinal study. Article Swipe
Filipa Raposo Pereira
,
Maximilien Chaumon
,
Bruno Dubois
,
Valentina La Corte
,
Nathalie George
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.077073
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.077073
Background The challenge in Alzheimer’s disease (AD) research ‐the world most prevalent dementia‐remains on finding preclinical markers that can predict progression to the disease. In this respect electrophysiological (EEG) measures seem promising, based on their sensitivity to the appearance of subtle episodic memory (EM) alterations, which become an AD risk‐factor when in the presence of B‐amyloid burden (AB+; AD‐biomarker) (Paitel et al., 2021; Olichney et al., 2011). We aimed to identify event‐related potential (ERP) signatures of AD‐linked EM alterations in elder cognitively normal subjects at‐risk for AD. Methods EEG data was collected longitudinally with an EGI 256‐channels cap, over 6 yearly sessions, in 15 controls (AB‐), 15 non‐converters (AB+), and 15 converters to prodromal‐AD (AB+; who converted during follow‐up but were only considered before diagnosis) from the INSIGHTpre‐AD cohort. We analysed the typical ERP response to a classic task of verbal memory recognition of old or new words (i.e. P3 and FN400 [0.25‐0.34 and 0.51‐0.57ms], P600 [0.62‐0.77ms], and monitoring [0.87‐1.04ms]). The new words were related to the old words (previously encoded) either in their number of repetitions (NR) or in their semantic content but presented once (NU). Source‐localization analysis of these data is currently underway. Results During follow‐up, the converters showed increased reaction time and decreased accuracy in word recognition when compared with the other groups. The converters significantly showed greater mean amplitude in the fronto‐parietal left and parieto‐occipital central regions typically linked to EM recollection, in the 0.25‐0.34 ms time‐window when compared with the controls, and in the 0.51‐0.57ms time‐window when compared with the non‐converters. Through our period of interest, old words activated mostly central‐posterior left regions (semantic networks/familiarity), NR words activated the frontal right region (i.e. novelty detection), and NU words frontal‐temporal right regions (semantic interference detection). Conclusion Our findings show amplitude differences associated with AD‐linked EM alterations years before individuals are diagnosed, representing potential ERP signatures of progression to AD in at‐risk individuals, while they remain cognitively normal. Anticipation of diagnosis contributes to the development of more effective tailor‐made treatments that potentially ease quality of life of patients and caregivers.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.077073
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390194421
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390194421Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/alz.077073Digital Object Identifier
- Title
-
Event‐related potential signatures of episodic memory decline predicting progression to Alzheimer’s disease in asymptomatic at‐risk subjects: a longitudinal study.Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-01Full publication date if available
- Authors
-
Filipa Raposo Pereira, Maximilien Chaumon, Bruno Dubois, Valentina La Corte, Nathalie GeorgeList of authors in order
- Landing page
-
https://doi.org/10.1002/alz.077073Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073Direct OA link when available
- Concepts
-
Dementia, Episodic memory, Audiology, Event-related potential, Biomarker, Electroencephalography, Disease, Psychology, Asymptomatic, Cohort, Medicine, Neuroscience, Cognition, Internal medicine, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390194421 |
|---|---|
| doi | https://doi.org/10.1002/alz.077073 |
| ids.doi | https://doi.org/10.1002/alz.077073 |
| ids.openalex | https://openalex.org/W4390194421 |
| fwci | 0.0 |
| type | article |
| title | Event‐related potential signatures of episodic memory decline predicting progression to Alzheimer’s disease in asymptomatic at‐risk subjects: a longitudinal study. |
| biblio.issue | S17 |
| biblio.volume | 19 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10429 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.8269000053405762 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2805 |
| topics[0].subfield.display_name | Cognitive Neuroscience |
| topics[0].display_name | EEG and Brain-Computer Interfaces |
| is_xpac | False |
| apc_list.value | 4000 |
| apc_list.currency | USD |
| apc_list.value_usd | 4000 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779483572 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6671804785728455 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[0].display_name | Dementia |
| concepts[1].id | https://openalex.org/C88576662 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6093409657478333 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q18646 |
| concepts[1].display_name | Episodic memory |
| concepts[2].id | https://openalex.org/C548259974 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5965293049812317 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q569965 |
| concepts[2].display_name | Audiology |
| concepts[3].id | https://openalex.org/C67359045 |
| concepts[3].level | 3 |
| concepts[3].score | 0.578349769115448 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q14026181 |
| concepts[3].display_name | Event-related potential |
| concepts[4].id | https://openalex.org/C2781197716 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5380641222000122 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q864574 |
| concepts[4].display_name | Biomarker |
| concepts[5].id | https://openalex.org/C522805319 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5158733129501343 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q179965 |
| concepts[5].display_name | Electroencephalography |
| concepts[6].id | https://openalex.org/C2779134260 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5095203518867493 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[6].display_name | Disease |
| concepts[7].id | https://openalex.org/C15744967 |
| concepts[7].level | 0 |
| concepts[7].score | 0.5000700950622559 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[7].display_name | Psychology |
| concepts[8].id | https://openalex.org/C2777910003 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4915867745876312 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1707292 |
| concepts[8].display_name | Asymptomatic |
| concepts[9].id | https://openalex.org/C72563966 |
| concepts[9].level | 2 |
| concepts[9].score | 0.44059547781944275 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[9].display_name | Cohort |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.4167887568473816 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C169760540 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3264507055282593 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[11].display_name | Neuroscience |
| concepts[12].id | https://openalex.org/C169900460 |
| concepts[12].level | 2 |
| concepts[12].score | 0.31782853603363037 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q2200417 |
| concepts[12].display_name | Cognition |
| concepts[13].id | https://openalex.org/C126322002 |
| concepts[13].level | 1 |
| concepts[13].score | 0.24927732348442078 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[13].display_name | Internal medicine |
| concepts[14].id | https://openalex.org/C86803240 |
| concepts[14].level | 0 |
| concepts[14].score | 0.10926434397697449 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[14].display_name | Biology |
| concepts[15].id | https://openalex.org/C55493867 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[15].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/dementia |
| keywords[0].score | 0.6671804785728455 |
| keywords[0].display_name | Dementia |
| keywords[1].id | https://openalex.org/keywords/episodic-memory |
| keywords[1].score | 0.6093409657478333 |
| keywords[1].display_name | Episodic memory |
| keywords[2].id | https://openalex.org/keywords/audiology |
| keywords[2].score | 0.5965293049812317 |
| keywords[2].display_name | Audiology |
| keywords[3].id | https://openalex.org/keywords/event-related-potential |
| keywords[3].score | 0.578349769115448 |
| keywords[3].display_name | Event-related potential |
| keywords[4].id | https://openalex.org/keywords/biomarker |
| keywords[4].score | 0.5380641222000122 |
| keywords[4].display_name | Biomarker |
| keywords[5].id | https://openalex.org/keywords/electroencephalography |
| keywords[5].score | 0.5158733129501343 |
| keywords[5].display_name | Electroencephalography |
| keywords[6].id | https://openalex.org/keywords/disease |
| keywords[6].score | 0.5095203518867493 |
| keywords[6].display_name | Disease |
| keywords[7].id | https://openalex.org/keywords/psychology |
| keywords[7].score | 0.5000700950622559 |
| keywords[7].display_name | Psychology |
| keywords[8].id | https://openalex.org/keywords/asymptomatic |
| keywords[8].score | 0.4915867745876312 |
| keywords[8].display_name | Asymptomatic |
| keywords[9].id | https://openalex.org/keywords/cohort |
| keywords[9].score | 0.44059547781944275 |
| keywords[9].display_name | Cohort |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.4167887568473816 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/neuroscience |
| keywords[11].score | 0.3264507055282593 |
| keywords[11].display_name | Neuroscience |
| keywords[12].id | https://openalex.org/keywords/cognition |
| keywords[12].score | 0.31782853603363037 |
| keywords[12].display_name | Cognition |
| keywords[13].id | https://openalex.org/keywords/internal-medicine |
| keywords[13].score | 0.24927732348442078 |
| keywords[13].display_name | Internal medicine |
| keywords[14].id | https://openalex.org/keywords/biology |
| keywords[14].score | 0.10926434397697449 |
| keywords[14].display_name | Biology |
| language | en |
| locations[0].id | doi:10.1002/alz.077073 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S108427512 |
| locations[0].source.issn | 1552-5260, 1552-5279 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1552-5260 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Alzheimer s & Dementia |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Alzheimer's & Dementia |
| locations[0].landing_page_url | https://doi.org/10.1002/alz.077073 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5046951417 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6199-7164 |
| authorships[0].author.display_name | Filipa Raposo Pereira |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210152724 |
| authorships[0].affiliations[0].raw_affiliation_string | Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEGParis Brain Institute, Paris France |
| authorships[0].affiliations[1].raw_affiliation_string | Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Départment de Neurologie, Paris France |
| authorships[0].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[0].institutions[1].id | https://openalex.org/I154526488 |
| authorships[0].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[1].type | government |
| authorships[0].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Inserm |
| authorships[0].institutions[2].id | https://openalex.org/I4210152724 |
| authorships[0].institutions[2].ror | https://ror.org/050gn5214 |
| authorships[0].institutions[2].type | facility |
| authorships[0].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210096427, https://openalex.org/I4210152724 |
| authorships[0].institutions[2].country_code | FR |
| authorships[0].institutions[2].display_name | Institut du Cerveau |
| authorships[0].institutions[3].id | https://openalex.org/I39804081 |
| authorships[0].institutions[3].ror | https://ror.org/02en5vm52 |
| authorships[0].institutions[3].type | education |
| authorships[0].institutions[3].lineage | https://openalex.org/I39804081 |
| authorships[0].institutions[3].country_code | FR |
| authorships[0].institutions[3].display_name | Sorbonne Université |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Filipa Raposo Pereira |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Départment de Neurologie, Paris France, Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEGParis Brain Institute, Paris France |
| authorships[1].author.id | https://openalex.org/A5064551137 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9664-8861 |
| authorships[1].author.display_name | Maximilien Chaumon |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210152724 |
| authorships[1].affiliations[0].raw_affiliation_string | Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEG, Paris France |
| authorships[1].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[1].institutions[1].id | https://openalex.org/I154526488 |
| authorships[1].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[1].type | government |
| authorships[1].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Inserm |
| authorships[1].institutions[2].id | https://openalex.org/I4210152724 |
| authorships[1].institutions[2].ror | https://ror.org/050gn5214 |
| authorships[1].institutions[2].type | facility |
| authorships[1].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210096427, https://openalex.org/I4210152724 |
| authorships[1].institutions[2].country_code | FR |
| authorships[1].institutions[2].display_name | Institut du Cerveau |
| authorships[1].institutions[3].id | https://openalex.org/I39804081 |
| authorships[1].institutions[3].ror | https://ror.org/02en5vm52 |
| authorships[1].institutions[3].type | education |
| authorships[1].institutions[3].lineage | https://openalex.org/I39804081 |
| authorships[1].institutions[3].country_code | FR |
| authorships[1].institutions[3].display_name | Sorbonne Université |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Maximilien Chaumon |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEG, Paris France |
| authorships[2].author.id | https://openalex.org/A5108138196 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Bruno Dubois |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I39804081, https://openalex.org/I4210121705 |
| authorships[2].affiliations[0].raw_affiliation_string | Sorbonne Université, AP‐HP, Hôpital de la Pitié‐Salpêtrière, Boulevard de l'hôpital, Paris France |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I39804081 |
| authorships[2].affiliations[1].raw_affiliation_string | Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), ICM, Salpetriere Hospital, AP‐HP, University Paris 6, Paris France |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I39804081, https://openalex.org/I4210121705, https://openalex.org/I4389425465 |
| authorships[2].affiliations[2].raw_affiliation_string | Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP‐HP, Pitié‐Salpêtrière Hospital, Boulevard de l'hôpital, F‐75013, Paris France |
| authorships[2].institutions[0].id | https://openalex.org/I4389425465 |
| authorships[2].institutions[0].ror | https://ror.org/058qr4y65 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I39804081, https://openalex.org/I4389425465 |
| authorships[2].institutions[0].country_code | |
| authorships[2].institutions[0].display_name | Alzheimer Precision Medicine |
| authorships[2].institutions[1].id | https://openalex.org/I4210121705 |
| authorships[2].institutions[1].ror | https://ror.org/02mh9a093 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210097159, https://openalex.org/I4210121705 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Pitié-Salpêtrière Hospital |
| authorships[2].institutions[2].id | https://openalex.org/I39804081 |
| authorships[2].institutions[2].ror | https://ror.org/02en5vm52 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I39804081 |
| authorships[2].institutions[2].country_code | FR |
| authorships[2].institutions[2].display_name | Sorbonne Université |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Bruno Dubois |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), ICM, Salpetriere Hospital, AP‐HP, University Paris 6, Paris France, Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP‐HP, Pitié‐Salpêtrière Hospital, Boulevard de l'hôpital, F‐75013, Paris France, Sorbonne Université, AP‐HP, Hôpital de la Pitié‐Salpêtrière, Boulevard de l'hôpital, Paris France |
| authorships[3].author.id | https://openalex.org/A5068972900 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Valentina La Corte |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].raw_affiliation_string | Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Départment de Neurologie, Paris France |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I110736937, https://openalex.org/I204730241, https://openalex.org/I4210091437 |
| authorships[3].affiliations[1].raw_affiliation_string | Institute of Psychology, University Paris Descartes, Sorbonne Paris Cite, Paris France |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I204730241, https://openalex.org/I4210124483 |
| authorships[3].affiliations[2].raw_affiliation_string | Laboratoire Mémoire, Cerveau et Cognition (MC2Lab), EA 7536, Université de Paris,, Paris France |
| authorships[3].affiliations[3].institution_ids | https://openalex.org/I185839726 |
| authorships[3].affiliations[3].raw_affiliation_string | Institut Universitaire de France, Paris France |
| authorships[3].institutions[0].id | https://openalex.org/I110736937 |
| authorships[3].institutions[0].ror | https://ror.org/02e0y6e06 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I110736937, https://openalex.org/I154526488 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Délégation Paris 5 |
| authorships[3].institutions[1].id | https://openalex.org/I185839726 |
| authorships[3].institutions[1].ror | https://ror.org/055khg266 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I185839726 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Institut Universitaire de France |
| authorships[3].institutions[2].id | https://openalex.org/I4210124483 |
| authorships[3].institutions[2].ror | https://ror.org/036ydxy43 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I154526488, https://openalex.org/I204730241, https://openalex.org/I4210124483, https://openalex.org/I4210150564, https://openalex.org/I4210163442 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Laboratoire Mémoire et Cognition |
| authorships[3].institutions[3].id | https://openalex.org/I4210091437 |
| authorships[3].institutions[3].ror | https://ror.org/001z21q04 |
| authorships[3].institutions[3].type | other |
| authorships[3].institutions[3].lineage | https://openalex.org/I4210091437 |
| authorships[3].institutions[3].country_code | FR |
| authorships[3].institutions[3].display_name | Sorbonne Paris Cité |
| authorships[3].institutions[4].id | https://openalex.org/I204730241 |
| authorships[3].institutions[4].ror | https://ror.org/05f82e368 |
| authorships[3].institutions[4].type | education |
| authorships[3].institutions[4].lineage | https://openalex.org/I204730241 |
| authorships[3].institutions[4].country_code | FR |
| authorships[3].institutions[4].display_name | Université Paris Cité |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Valentina La Corte |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institut Universitaire de France, Paris France, Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Départment de Neurologie, Paris France, Institute of Psychology, University Paris Descartes, Sorbonne Paris Cite, Paris France, Laboratoire Mémoire, Cerveau et Cognition (MC2Lab), EA 7536, Université de Paris,, Paris France |
| authorships[4].author.id | https://openalex.org/A5000693199 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1556-973X |
| authorships[4].author.display_name | Nathalie George |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210152724 |
| authorships[4].affiliations[0].raw_affiliation_string | Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEG, Paris France |
| authorships[4].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[4].institutions[1].id | https://openalex.org/I154526488 |
| authorships[4].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[1].type | government |
| authorships[4].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Inserm |
| authorships[4].institutions[2].id | https://openalex.org/I4210152724 |
| authorships[4].institutions[2].ror | https://ror.org/050gn5214 |
| authorships[4].institutions[2].type | facility |
| authorships[4].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210096427, https://openalex.org/I4210152724 |
| authorships[4].institutions[2].country_code | FR |
| authorships[4].institutions[2].display_name | Institut du Cerveau |
| authorships[4].institutions[3].id | https://openalex.org/I39804081 |
| authorships[4].institutions[3].ror | https://ror.org/02en5vm52 |
| authorships[4].institutions[3].type | education |
| authorships[4].institutions[3].lineage | https://openalex.org/I39804081 |
| authorships[4].institutions[3].country_code | FR |
| authorships[4].institutions[3].display_name | Sorbonne Université |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Nathalie George |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Sorbonne Université, Paris Brain Institute (ICM), INSERM, CNRS, CENIR MEG‐EEG, Paris France |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Event‐related potential signatures of episodic memory decline predicting progression to Alzheimer’s disease in asymptomatic at‐risk subjects: a longitudinal study. |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10429 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.8269000053405762 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2805 |
| primary_topic.subfield.display_name | Cognitive Neuroscience |
| primary_topic.display_name | EEG and Brain-Computer Interfaces |
| related_works | https://openalex.org/W2097753790, https://openalex.org/W2049776456, https://openalex.org/W2781494228, https://openalex.org/W1627705222, https://openalex.org/W3119120477, https://openalex.org/W2951399089, https://openalex.org/W2562811035, https://openalex.org/W4230540696, https://openalex.org/W3044331089, https://openalex.org/W2466743278 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1002/alz.077073 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S108427512 |
| best_oa_location.source.issn | 1552-5260, 1552-5279 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1552-5260 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Alzheimer s & Dementia |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Alzheimer's & Dementia |
| best_oa_location.landing_page_url | https://doi.org/10.1002/alz.077073 |
| primary_location.id | doi:10.1002/alz.077073 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S108427512 |
| primary_location.source.issn | 1552-5260, 1552-5279 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1552-5260 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Alzheimer s & Dementia |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.077073 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Alzheimer's & Dementia |
| primary_location.landing_page_url | https://doi.org/10.1002/alz.077073 |
| publication_date | 2023-12-01 |
| publication_year | 2023 |
| referenced_works_count | 0 |
| abstract_inverted_index.6 | 100 |
| abstract_inverted_index.a | 137 |
| abstract_inverted_index.15 | 104, 107, 111 |
| abstract_inverted_index.AD | 49, 313 |
| abstract_inverted_index.EM | 78, 235, 299 |
| abstract_inverted_index.In | 25 |
| abstract_inverted_index.NR | 271 |
| abstract_inverted_index.NU | 282 |
| abstract_inverted_index.P3 | 150 |
| abstract_inverted_index.We | 68, 130 |
| abstract_inverted_index.an | 48, 95 |
| abstract_inverted_index.et | 61, 65 |
| abstract_inverted_index.in | 4, 52, 80, 103, 173, 180, 208, 224, 237, 248, 314 |
| abstract_inverted_index.is | 193 |
| abstract_inverted_index.ms | 240 |
| abstract_inverted_index.of | 40, 55, 76, 140, 144, 176, 190, 260, 310, 323, 329, 338, 340 |
| abstract_inverted_index.on | 14, 34 |
| abstract_inverted_index.or | 146, 179 |
| abstract_inverted_index.to | 22, 37, 70, 113, 136, 166, 234, 312, 326 |
| abstract_inverted_index.AD. | 87 |
| abstract_inverted_index.EEG | 89 |
| abstract_inverted_index.EGI | 96 |
| abstract_inverted_index.ERP | 134, 308 |
| abstract_inverted_index.Our | 291 |
| abstract_inverted_index.The | 2, 161, 217 |
| abstract_inverted_index.and | 110, 151, 154, 158, 205, 228, 247, 281, 342 |
| abstract_inverted_index.are | 304 |
| abstract_inverted_index.but | 120, 184 |
| abstract_inverted_index.can | 19 |
| abstract_inverted_index.for | 86 |
| abstract_inverted_index.new | 147, 162 |
| abstract_inverted_index.old | 145, 168, 262 |
| abstract_inverted_index.our | 258 |
| abstract_inverted_index.the | 23, 38, 53, 127, 132, 167, 199, 214, 225, 238, 245, 249, 255, 274, 327 |
| abstract_inverted_index.was | 91 |
| abstract_inverted_index.who | 116 |
| abstract_inverted_index.(AD) | 7 |
| abstract_inverted_index.(EM) | 44 |
| abstract_inverted_index.(NR) | 178 |
| abstract_inverted_index.P600 | 156 |
| abstract_inverted_index.al., | 62, 66 |
| abstract_inverted_index.cap, | 98 |
| abstract_inverted_index.data | 90, 192 |
| abstract_inverted_index.ease | 336 |
| abstract_inverted_index.from | 126 |
| abstract_inverted_index.left | 227, 267 |
| abstract_inverted_index.life | 339 |
| abstract_inverted_index.mean | 222 |
| abstract_inverted_index.more | 330 |
| abstract_inverted_index.most | 11 |
| abstract_inverted_index.once | 186 |
| abstract_inverted_index.only | 122 |
| abstract_inverted_index.over | 99 |
| abstract_inverted_index.seem | 31 |
| abstract_inverted_index.show | 293 |
| abstract_inverted_index.task | 139 |
| abstract_inverted_index.that | 18, 334 |
| abstract_inverted_index.they | 318 |
| abstract_inverted_index.this | 26 |
| abstract_inverted_index.time | 204 |
| abstract_inverted_index.were | 121, 164 |
| abstract_inverted_index.when | 51, 211, 242, 252 |
| abstract_inverted_index.with | 94, 213, 244, 254, 297 |
| abstract_inverted_index.word | 209 |
| abstract_inverted_index.(AB+; | 58, 115 |
| abstract_inverted_index.(EEG) | 29 |
| abstract_inverted_index.(ERP) | 74 |
| abstract_inverted_index.(NU). | 187 |
| abstract_inverted_index.(i.e. | 149, 278 |
| abstract_inverted_index.2021; | 63 |
| abstract_inverted_index.FN400 | 152 |
| abstract_inverted_index.aimed | 69 |
| abstract_inverted_index.based | 33 |
| abstract_inverted_index.elder | 81 |
| abstract_inverted_index.other | 215 |
| abstract_inverted_index.right | 276, 285 |
| abstract_inverted_index.their | 35, 174, 181 |
| abstract_inverted_index.these | 191 |
| abstract_inverted_index.which | 46 |
| abstract_inverted_index.while | 317 |
| abstract_inverted_index.words | 148, 163, 169, 263, 272, 283 |
| abstract_inverted_index.world | 10 |
| abstract_inverted_index.years | 301 |
| abstract_inverted_index.(AB+), | 109 |
| abstract_inverted_index.2011). | 67 |
| abstract_inverted_index.During | 197 |
| abstract_inverted_index.become | 47 |
| abstract_inverted_index.before | 124, 302 |
| abstract_inverted_index.burden | 57 |
| abstract_inverted_index.during | 118 |
| abstract_inverted_index.either | 172 |
| abstract_inverted_index.linked | 233 |
| abstract_inverted_index.memory | 43, 142 |
| abstract_inverted_index.mostly | 265 |
| abstract_inverted_index.normal | 83 |
| abstract_inverted_index.number | 175 |
| abstract_inverted_index.period | 259 |
| abstract_inverted_index.region | 277 |
| abstract_inverted_index.remain | 319 |
| abstract_inverted_index.showed | 201, 220 |
| abstract_inverted_index.subtle | 41 |
| abstract_inverted_index.verbal | 141 |
| abstract_inverted_index.yearly | 101 |
| abstract_inverted_index.‐the | 9 |
| abstract_inverted_index.(Paitel | 60 |
| abstract_inverted_index.Methods | 88 |
| abstract_inverted_index.Results | 196 |
| abstract_inverted_index.Through | 257 |
| abstract_inverted_index.central | 230 |
| abstract_inverted_index.classic | 138 |
| abstract_inverted_index.cohort. | 129 |
| abstract_inverted_index.content | 183 |
| abstract_inverted_index.disease | 6 |
| abstract_inverted_index.finding | 15 |
| abstract_inverted_index.frontal | 275 |
| abstract_inverted_index.greater | 221 |
| abstract_inverted_index.groups. | 216 |
| abstract_inverted_index.markers | 17 |
| abstract_inverted_index.normal. | 321 |
| abstract_inverted_index.novelty | 279 |
| abstract_inverted_index.predict | 20 |
| abstract_inverted_index.quality | 337 |
| abstract_inverted_index.regions | 231, 268, 286 |
| abstract_inverted_index.related | 165 |
| abstract_inverted_index.respect | 27 |
| abstract_inverted_index.typical | 133 |
| abstract_inverted_index.(AB‐), | 106 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Olichney | 64 |
| abstract_inverted_index.accuracy | 207 |
| abstract_inverted_index.analysed | 131 |
| abstract_inverted_index.analysis | 189 |
| abstract_inverted_index.compared | 212, 243, 253 |
| abstract_inverted_index.controls | 105 |
| abstract_inverted_index.disease. | 24 |
| abstract_inverted_index.encoded) | 171 |
| abstract_inverted_index.episodic | 42 |
| abstract_inverted_index.findings | 292 |
| abstract_inverted_index.identify | 71 |
| abstract_inverted_index.measures | 30 |
| abstract_inverted_index.patients | 341 |
| abstract_inverted_index.presence | 54 |
| abstract_inverted_index.reaction | 203 |
| abstract_inverted_index.research | 8 |
| abstract_inverted_index.response | 135 |
| abstract_inverted_index.semantic | 182 |
| abstract_inverted_index.subjects | 84 |
| abstract_inverted_index.(semantic | 269, 287 |
| abstract_inverted_index.activated | 264, 273 |
| abstract_inverted_index.amplitude | 223, 294 |
| abstract_inverted_index.at‐risk | 85, 315 |
| abstract_inverted_index.challenge | 3 |
| abstract_inverted_index.collected | 92 |
| abstract_inverted_index.controls, | 246 |
| abstract_inverted_index.converted | 117 |
| abstract_inverted_index.currently | 194 |
| abstract_inverted_index.decreased | 206 |
| abstract_inverted_index.diagnosis | 324 |
| abstract_inverted_index.effective | 331 |
| abstract_inverted_index.increased | 202 |
| abstract_inverted_index.interest, | 261 |
| abstract_inverted_index.potential | 73, 307 |
| abstract_inverted_index.presented | 185 |
| abstract_inverted_index.prevalent | 12 |
| abstract_inverted_index.sessions, | 102 |
| abstract_inverted_index.typically | 232 |
| abstract_inverted_index.underway. | 195 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 290 |
| abstract_inverted_index.appearance | 39 |
| abstract_inverted_index.associated | 296 |
| abstract_inverted_index.considered | 123 |
| abstract_inverted_index.converters | 112, 200, 218 |
| abstract_inverted_index.diagnosed, | 305 |
| abstract_inverted_index.diagnosis) | 125 |
| abstract_inverted_index.monitoring | 159 |
| abstract_inverted_index.promising, | 32 |
| abstract_inverted_index.signatures | 75, 309 |
| abstract_inverted_index.treatments | 333 |
| abstract_inverted_index.(previously | 170 |
| abstract_inverted_index.0.25‐0.34 | 239 |
| abstract_inverted_index.AD‐linked | 77, 298 |
| abstract_inverted_index.B‐amyloid | 56 |
| abstract_inverted_index.alterations | 79, 300 |
| abstract_inverted_index.caregivers. | 343 |
| abstract_inverted_index.cognitively | 82, 320 |
| abstract_inverted_index.contributes | 325 |
| abstract_inverted_index.detection), | 280 |
| abstract_inverted_index.detection). | 289 |
| abstract_inverted_index.development | 328 |
| abstract_inverted_index.differences | 295 |
| abstract_inverted_index.follow‐up | 119 |
| abstract_inverted_index.individuals | 303 |
| abstract_inverted_index.potentially | 335 |
| abstract_inverted_index.preclinical | 16 |
| abstract_inverted_index.progression | 21, 311 |
| abstract_inverted_index.recognition | 143, 210 |
| abstract_inverted_index.repetitions | 177 |
| abstract_inverted_index.sensitivity | 36 |
| abstract_inverted_index.Anticipation | 322 |
| abstract_inverted_index.[0.25‐0.34 | 153 |
| abstract_inverted_index.alterations, | 45 |
| abstract_inverted_index.follow‐up, | 198 |
| abstract_inverted_index.individuals, | 316 |
| abstract_inverted_index.interference | 288 |
| abstract_inverted_index.representing | 306 |
| abstract_inverted_index.0.51‐0.57ms | 250 |
| abstract_inverted_index.Alzheimer’s | 5 |
| abstract_inverted_index.recollection, | 236 |
| abstract_inverted_index.risk‐factor | 50 |
| abstract_inverted_index.significantly | 219 |
| abstract_inverted_index.tailor‐made | 332 |
| abstract_inverted_index.time‐window | 241, 251 |
| abstract_inverted_index.256‐channels | 97 |
| abstract_inverted_index.longitudinally | 93 |
| abstract_inverted_index.prodromal‐AD | 114 |
| abstract_inverted_index.0.51‐0.57ms], | 155 |
| abstract_inverted_index.AD‐biomarker) | 59 |
| abstract_inverted_index.INSIGHTpre‐AD | 128 |
| abstract_inverted_index.event‐related | 72 |
| abstract_inverted_index.[0.62‐0.77ms], | 157 |
| abstract_inverted_index.non‐converters | 108 |
| abstract_inverted_index.[0.87‐1.04ms]). | 160 |
| abstract_inverted_index.fronto‐parietal | 226 |
| abstract_inverted_index.non‐converters. | 256 |
| abstract_inverted_index.dementia‐remains | 13 |
| abstract_inverted_index.frontal‐temporal | 284 |
| abstract_inverted_index.central‐posterior | 266 |
| abstract_inverted_index.parieto‐occipital | 229 |
| abstract_inverted_index.electrophysiological | 28 |
| abstract_inverted_index.Source‐localization | 188 |
| abstract_inverted_index.networks/familiarity), | 270 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5046951417 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I39804081, https://openalex.org/I4210152724 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.6000000238418579 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.24162216 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |