Evidence-based pharmacological strategies for gambling disorder Article Swipe
D. Vasile
,
O. Vasiliu
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.26416/psih.66.3.2021.5370
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.26416/psih.66.3.2021.5370
Pathological gambling is a diagnostic undergoing continuous reassessment, being considered an impulse-control disorder, a behavioral addiction assimilated with a substance-related disorder, or even a disorder from the obsessive-compulsive spectrum. The neurobiology of this pathology is complex, with dysfunctions of the dopaminergic, serotonergic, noradrenergic, opioidergic, glutamatergic and GABA-ergic systems, which involve the amygdala, striatum, prefrontal cortex etc. The main classes of pharmacological agents studied for the therapy of gambling addiction are antidepressants, mood stabilizers and opioid receptor antagonists. In addition, a variety of other agents have been investigated, with controversial results, from psychostimulants like modafinil to glutamatergic agents like amantadine, and from disulfiram to GABA-ergic modulators such as baclofen. What is certain is that, so far, no drug has been approved at the European or worldwide level by a pharmaceutical regulatory authority for the treatment of pathological gambling. Therefore, the therapeutic guidelines warn about the need to inform the patient that the medication offered is used off-label and about the need to combine pharmacotherapy with other types of treatment that have a higher level of evidence, such as cognitive-behavioral therapy.
Related Topics
Concepts
Modafinil
Glutamatergic
Serotonergic
Addiction
Neuroscience
Impulsivity
Dopaminergic
Psychology
Medicine
Psychiatry
Dopamine
Glutamate receptor
Internal medicine
Receptor
Serotonin
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.26416/psih.66.3.2021.5370
- OA Status
- diamond
- Cited By
- 1
- References
- 64
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3203306020Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26416/psih.66.3.2021.5370Digital Object Identifier
- Title
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Evidence-based pharmacological strategies for gambling disorderWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-01Full publication date if available
- Authors
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D. Vasile, O. VasiliuList of authors in order
- Landing page
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https://doi.org/10.26416/psih.66.3.2021.5370Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.26416/psih.66.3.2021.5370Direct OA link when available
- Concepts
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Modafinil, Glutamatergic, Serotonergic, Addiction, Neuroscience, Impulsivity, Dopaminergic, Psychology, Medicine, Psychiatry, Dopamine, Glutamate receptor, Internal medicine, Receptor, SerotoninTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.dopaminergic, | 40 |
| abstract_inverted_index.glutamatergic | 44, 95 |
| abstract_inverted_index.investigated, | 86 |
| abstract_inverted_index.reassessment, | 7 |
| abstract_inverted_index.serotonergic, | 41 |
| abstract_inverted_index.noradrenergic, | 42 |
| abstract_inverted_index.pharmaceutical | 128 |
| abstract_inverted_index.impulse-control | 11 |
| abstract_inverted_index.pharmacological | 60 |
| abstract_inverted_index.pharmacotherapy | 162 |
| abstract_inverted_index.antidepressants, | 70 |
| abstract_inverted_index.psychostimulants | 91 |
| abstract_inverted_index.substance-related | 19 |
| abstract_inverted_index.cognitive-behavioral | 177 |
| abstract_inverted_index.obsessive-compulsive | 27 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 2 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/8 |
| sustainable_development_goals[0].score | 0.5099999904632568 |
| sustainable_development_goals[0].display_name | Decent work and economic growth |
| citation_normalized_percentile.value | 0.17925427 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |