Evolution and Innovations in Bone Marrow Cellular Therapy for Musculoskeletal Disorders: Tracing the Historical Trajectory and Contemporary Advances Article Swipe
José Fábio Lana
,
Gabriela Caponero de Brito
,
André Kruel
,
Benjamim Brito
,
Gabriel Silva Santos
,
Carolina Caliari
,
Francesca Salamanna
,
Maria Sartori
,
Giovanni Barbanti Bròdano
,
Fábio Ramos Costa
,
Madhan Jeyaraman
,
Ignácio Dallo
,
Pedro Bernáldez
,
Joseph Purita
,
Marco Antônio Percope de Andrade
,
Peter A. Everts
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bioengineering11100979
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bioengineering11100979
Bone marrow cellular therapy has undergone a remarkable evolution, significantly impacting the treatment of musculoskeletal disorders. This review traces the historical trajectory from early mythological references to contemporary scientific advancements. The groundbreaking work of Friedenstein in 1968, identifying fibroblast colony-forming cells in bone marrow, laid the foundation for future studies. Caplan’s subsequent identification of mesenchymal stem cells (MSCs) in 1991 highlighted their differentiation potential and immunomodulatory properties, establishing them as key players in regenerative medicine. Contemporary research has focused on refining techniques for isolating and applying bone marrow-derived MSCs. These cells have shown promise in treating conditions like osteonecrosis, osteoarthritis, and tendon injuries thanks to their ability to promote tissue repair, modulate immune responses, and enhance angiogenesis. Clinical studies have demonstrated significant improvements in pain relief, functional recovery, and tissue regeneration. Innovations such as the ACH classification system and advancements in bone marrow aspiration methods have standardized practices, improving the consistency and efficacy of these therapies. Recent clinical trials have validated the therapeutic potential of bone marrow-derived products, highlighting their advantages in both surgical and non-surgical applications. Studies have shown that MSCs can reduce inflammation, support bone healing, and enhance cartilage repair. However, challenges remain, including the need for rigorous characterization of cell populations and standardized reporting in clinical trials. Addressing these issues is crucial for advancing the field and ensuring the reliable application of these therapies. Looking ahead, future research should focus on integrating bone marrow-derived products with other regenerative techniques and exploring non-surgical interventions. The continued innovation and refinement of these therapies hold promise for revolutionizing the treatment of musculoskeletal disorders, offering improved patient outcomes, and advancing the boundaries of medical science.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/bioengineering11100979
- OA Status
- gold
- Cited By
- 2
- References
- 62
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402987491Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/bioengineering11100979Digital Object Identifier
- Title
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Evolution and Innovations in Bone Marrow Cellular Therapy for Musculoskeletal Disorders: Tracing the Historical Trajectory and Contemporary AdvancesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-28Full publication date if available
- Authors
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José Fábio Lana, Gabriela Caponero de Brito, André Kruel, Benjamim Brito, Gabriel Silva Santos, Carolina Caliari, Francesca Salamanna, Maria Sartori, Giovanni Barbanti Bròdano, Fábio Ramos Costa, Madhan Jeyaraman, Ignácio Dallo, Pedro Bernáldez, Joseph Purita, Marco Antônio Percope de Andrade, Peter A. EvertsList of authors in order
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https://doi.org/10.3390/bioengineering11100979Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/bioengineering11100979Direct OA link when available
- Concepts
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Medicine, Regenerative medicine, Bone marrow, Bone healing, Bone Marrow Stem Cell, Clinical trial, Stem cell, Bioinformatics, Mesenchymal stem cell, Intensive care medicine, Pathology, Surgery, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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