Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – A multimodal and comprehensive model Article Swipe
Carlo Perego
,
Francesca Fumagalli
,
F. Motta
,
Marianna Cerrato
,
Edoardo Micotti
,
Davide Olivari
,
Daria De Giorgio
,
Giulia Merigo
,
Angelo Di Clemente
,
Alessandra Mandelli
,
Gianluigi Forloni
,
Luigi Cervo
,
Roberto Furlan
,
Roberto Latini
,
Robert W. Neumar
,
Giuseppe Ristagno
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/0271678x241255599
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/0271678x241255599
Cardiac arrest (CA) is one of the leading causes of death worldwide. Due to hypoxic ischemic brain injury, CA survivors may experience variable degrees of neurological dysfunction. This study, for the first time, describes the progression of CA-induced neuropathology in the rat. CA rats displayed neurological and exploratory deficits. Brain MRI revealed cortical and striatal edema at 3 days (d), white matter (WM) damage in corpus callosum (CC), external capsule (EC), internal capsule (IC) at d7 and d14. At d3 a brain edema significantly correlated with neurological score. Parallel neuropathological studies showed neurodegeneration, reduced neuronal density in CA1 and hilus of hippocampus at d7 and d14, with cells dying at d3 in hilus. Microgliosis increased in cortex (Cx), caudate putamen (Cpu), CA1, CC, and EC up to d14. Astrogliosis increased earlier (d3 to d7) in Cx, Cpu, CC and EC compared to CA1 (d7 to d14). Plasma levels of neurofilament light (NfL) increased at d3 and remained elevated up to d14. NfL levels at d7 correlated with WM damage. The study shows the consequences up to 14d after CA in rats, introducing clinically relevant parameters such as advanced neuroimaging and blood biomarker useful to test therapeutic interventions in this model.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/0271678x241255599
- https://journals.sagepub.com/doi/pdf/10.1177/0271678X241255599
- OA Status
- hybrid
- Cited By
- 4
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398179967
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4398179967Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/0271678x241255599Digital Object Identifier
- Title
-
Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – A multimodal and comprehensive modelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-21Full publication date if available
- Authors
-
Carlo Perego, Francesca Fumagalli, F. Motta, Marianna Cerrato, Edoardo Micotti, Davide Olivari, Daria De Giorgio, Giulia Merigo, Angelo Di Clemente, Alessandra Mandelli, Gianluigi Forloni, Luigi Cervo, Roberto Furlan, Roberto Latini, Robert W. Neumar, Giuseppe RistagnoList of authors in order
- Landing page
-
https://doi.org/10.1177/0271678x241255599Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/0271678X241255599Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://journals.sagepub.com/doi/pdf/10.1177/0271678X241255599Direct OA link when available
- Concepts
-
Astrogliosis, Internal capsule, Neuropathology, Medicine, Corpus callosum, Neurodegeneration, Pathology, White matter, Brain damage, Neuroscience, Neuroinflammation, Traumatic brain injury, Internal medicine, Cardiology, Psychology, Central nervous system, Magnetic resonance imaging, Radiology, Disease, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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