Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring Article Swipe
Elena Kuzmin
,
Toby M. Baker
,
Tom Lesluyes
,
Jean Monlong
,
Kento T. Abe
,
Paula P. Coelho
,
Michael Schwartz
,
Joseph Del Corpo
,
Dongmei Zou
,
Geneviève Morin
,
Alain Pacis
,
Yang Yang
,
Constanza Martínez
,
Jarrett J. Barber
,
Hellen Kuasne
,
Rui Li
,
Mathieu Bourgey
,
Anne-Marie Fortier
,
Peter Davison
,
Atilla Ömeroğlu
,
Marie‐Christine Guiot
,
Quaid Morris
,
Claudia L. Kleinman
,
Sidong Huang
,
Anne‐Claude Gingras
,
Jiannis Ragoussis
,
Guillaume Bourque
,
Peter Van Loo
,
Morag Park
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2024.113988
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2024.113988
The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module we name PGCKA1. Genome-wide pooled overexpression screens using a barcoded library of human open reading frames identify chromosomal regions, including chr4p, that suppress proliferation when overexpressed in a context-dependent manner, implicating network interactions. Together, these results shed light on the early emergence of complex aneuploid karyotypes involving chr4p and adaptive landscapes shaping breast cancer genomes.
Related Topics
Concepts
Biology
Breast cancer
Context (archaeology)
Genetics
Gene
Cancer
Triple-negative breast cancer
Cancer research
Computational biology
Paleontology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2024.113988
- http://www.cell.com/article/S2211124724003164/pdf
- OA Status
- gold
- Cited By
- 18
- References
- 98
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393085953
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393085953Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.celrep.2024.113988Digital Object Identifier
- Title
-
Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiringWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-22Full publication date if available
- Authors
-
Elena Kuzmin, Toby M. Baker, Tom Lesluyes, Jean Monlong, Kento T. Abe, Paula P. Coelho, Michael Schwartz, Joseph Del Corpo, Dongmei Zou, Geneviève Morin, Alain Pacis, Yang Yang, Constanza Martínez, Jarrett J. Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter Davison, Atilla Ömeroğlu, Marie‐Christine Guiot, Quaid Morris, Claudia L. Kleinman, Sidong Huang, Anne‐Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag ParkList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2024.113988Publisher landing page
- PDF URL
-
https://www.cell.com/article/S2211124724003164/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.cell.com/article/S2211124724003164/pdfDirect OA link when available
- Concepts
-
Biology, Breast cancer, Context (archaeology), Genetics, Gene, Cancer, Triple-negative breast cancer, Cancer research, Computational biology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 7, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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98Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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