Evolution of Survival Impact of Molecular Target Agents in Patients with Advanced Hepatocellular Carcinoma Article Swipe
Kazufumi Kobayashi
,
Sadahisa Ogasawara
,
Aya Takahashi
,
Yuya Seko
,
Hidemi Unozawa
,
Rui Sato
,
Shunji Watanabe
,
Michihisa Moriguchi
,
Naoki Morimoto
,
Satoshi Tsuchiya
,
Kenji Iwai
,
Masanori Inoue
,
Keita Ogawa
,
Takamasa Ishino
,
T. Iwanaga
,
Takafumi Sakuma
,
Naoto Fujita
,
Hiroaki Kanzaki
,
Keisuke Koroki
,
Masato Nakamura
,
Naoya Kanogawa
,
Soichiro Kiyono
,
Takayuki Kondo
,
Tomoko Saito
,
Ryo Nakagawa
,
Eiichiro Suzuki
,
Yoshihiko Ooka
,
Shingo Nakamoto
,
Akinobu Tawada
,
Tetsuhiro Chiba
,
Makoto Arai
,
Tatsuo Kanda
,
Hitoshi Maruyama
,
Kengo Nagashima
,
Jun Kato
,
Norio Isoda
,
Takeshi Aramaki
,
Yoshito Itoh
,
Naoya Kato
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1159/000519868
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1159/000519868
Background and Aims: The prognosis of patients with advanced hepatocellular carcinoma (HCC) is expected to improve as multiple molecular target agents (MTAs) are now available. However, the impact of the availability of sequential MTAs has not been fully verified yet. Approach and Results: We retrospectively collected the data on the whole clinical course of 877 patients who received any MTAs as first-line systemic therapy for advanced HCC between June 2009 and March 2019. The study population was divided into 3 groups according to the date of first-line MTA administration (period 1: 2009–2012, n = 267; period 2: 2013–2016, n = 352; period 3: 2017–2019, n = 258). Then, we compared the number of MTAs used, overall survival (OS), and MTA treatment duration among the 3 groups. Analysis was also performed separately for advanced-stage and nonadvanced-stage HCC. The proportion of patients who received multiple MTAs was remarkably increased over time (1.1%, 10.2%, and 42.6% in periods 1, 2, and 3, respectively, p < 0.001). The median OS times were prolonged to 10.4, 11.3, and 15.2 months in periods 1, 2, and 3, respectively (p = 0.016). Similarly, the MTA treatment durations were extended (2.7, 3.2, and 6.6 months in periods 1, 2, and 3, respectively; p < 0.001). We confirmed that the correlation between OS and MTA treatment duration was strengthened (period 1: 0.395, period 2: 0.505, and period 3: 0.667). All these trends were pronounced in the patients with advanced-stage HCC but limited in the patients with nonadvanced-stage HCC. Conclusions: The availability of multiple MTAs had steadily improved the prognosis of patients with advanced HCC patients, particularly advanced-stage HCC patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1159/000519868
- OA Status
- gold
- Cited By
- 50
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200547311
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4200547311Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1159/000519868Digital Object Identifier
- Title
-
Evolution of Survival Impact of Molecular Target Agents in Patients with Advanced Hepatocellular CarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-06Full publication date if available
- Authors
-
Kazufumi Kobayashi, Sadahisa Ogasawara, Aya Takahashi, Yuya Seko, Hidemi Unozawa, Rui Sato, Shunji Watanabe, Michihisa Moriguchi, Naoki Morimoto, Satoshi Tsuchiya, Kenji Iwai, Masanori Inoue, Keita Ogawa, Takamasa Ishino, T. Iwanaga, Takafumi Sakuma, Naoto Fujita, Hiroaki Kanzaki, Keisuke Koroki, Masato Nakamura, Naoya Kanogawa, Soichiro Kiyono, Takayuki Kondo, Tomoko Saito, Ryo Nakagawa, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Akinobu Tawada, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Kengo Nagashima, Jun Kato, Norio Isoda, Takeshi Aramaki, Yoshito Itoh, Naoya KatoList of authors in order
- Landing page
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https://doi.org/10.1159/000519868Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1159/000519868Direct OA link when available
- Concepts
-
Medicine, Hepatocellular carcinoma, Internal medicine, Gastroenterology, Stage (stratigraphy), Population, Surgery, Biology, Paleontology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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50Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 16, 2023: 16, 2022: 12, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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