Evolution of the calcium feedback steps of vertebrate phototransduction Article Swipe
Trevor D. Lamb
,
David M. Hunt
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1098/rsob.180119
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1098/rsob.180119
We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the guanylyl cyclases (GCs) and the sodium/calcium-potassium exchangers (NCKXs). We identified a paralogon containing at least 36 phototransduction genes from at least fourteen families, including all four of the families involved in the Ca-feedback loop (recoverin/visinin, GCAPs, GCs and NCKXs). By combining analyses of gene synteny with analyses of the molecular phylogeny for each of these four families of genes for Ca-feedback regulation, we have established the likely pattern of gene duplications and losses underlying the expansion of isoforms, both before and during the two rounds of whole-genome duplication (2R WGD) that occurred in early vertebrate evolution. Furthermore, by combining our results with earlier evidence on the timing of duplication of the visual G-protein receptor kinase genes, we propose that specialization of proto-vertebrate photoreceptor cells for operation at high and low light intensities preceded the emergence of rhodopsin, which occurred during 2R WGD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1098/rsob.180119
- OA Status
- gold
- Cited By
- 20
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2893932691
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2893932691Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1098/rsob.180119Digital Object Identifier
- Title
-
Evolution of the calcium feedback steps of vertebrate phototransductionWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-09-01Full publication date if available
- Authors
-
Trevor D. Lamb, David M. HuntList of authors in order
- Landing page
-
https://doi.org/10.1098/rsob.180119Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1098/rsob.180119Direct OA link when available
- Concepts
-
Visual phototransduction, Recoverin, Biology, Gene duplication, Vertebrate, Synteny, Rhodopsin, Gene, Gene family, Cell biology, Gene isoform, Genetics, Calcium-binding protein, Eye Proteins, Evolutionary biology, Genome, Calcium, Biochemistry, Neuroscience, Retina, Internal medicine, Retinal, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 4, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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85Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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