Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions Article Swipe
Luca Schelle
,
João Vasco Côrte‐Real
,
Sharmeen Fayyaz
,
Augusto del Pozo Ben
,
Margarita Shnipova
,
Moritz Petersen
,
Rishikesh Lotke
,
B. Menon
,
Dana Matzek
,
Lena Pfaff
,
Ana Pinheiro
,
João Pedro Marques
,
José Melo‐Ferreira
,
Bastian Popper
,
Pedro J. Esteves
,
Daniel Sauter
,
Joana Abrantes
,
Hanna‐Mari Baldauf
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1303089
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1303089
Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases, and their expression can be partially induced by interferons (IFNs). GBPs are involved in the cell-autonomous innate immune response against bacterial, parasitic and viral infections. Evolutionary studies have shown that GBPs exhibit a pattern of gene gain and loss events, indicative for the birth-and-death model of evolution. Most species harbor large GBP gene clusters that encode multiple paralogs. Previous functional and in-depth evolutionary studies have mainly focused on murine and human GBPs. Since rabbits are another important model system for studying human diseases, we focus here on lagomorphs to broaden our understanding of the multifunctional GBP protein family by conducting evolutionary analyses and performing a molecular and functional characterization of rabbit GBPs. We observed that lagomorphs lack GBP3, 6 and 7 . Furthermore, Leporidae experienced a loss of GBP2 , a unique duplication of GBP5 and a massive expansion of GBP4 . Gene expression analysis by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and transcriptome data revealed that leporid GBP expression varied across tissues. Overexpressed rabbit GBPs localized either uniformly and/or discretely to the cytoplasm and/or to the nucleus. Oryctolagus cuniculus (oc)GBP5L1 and rarely ocGBP5L2 were an exception, colocalizing with the trans-Golgi network (TGN). In addition, four ocGBPs were IFN-inducible and only ocGBP5L2 inhibited furin activity. In conclusion, from an evolutionary perspective, lagomorph GBPs experienced multiple gain and loss events, and the molecular and functional characteristics of ocGBP suggest a role in innate immunity.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2024.1303089
- https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 3
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391320773
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391320773Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2024.1303089Digital Object Identifier
- Title
-
Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-29Full publication date if available
- Authors
-
Luca Schelle, João Vasco Côrte‐Real, Sharmeen Fayyaz, Augusto del Pozo Ben, Margarita Shnipova, Moritz Petersen, Rishikesh Lotke, B. Menon, Dana Matzek, Lena Pfaff, Ana Pinheiro, João Pedro Marques, José Melo‐Ferreira, Bastian Popper, Pedro J. Esteves, Daniel Sauter, Joana Abrantes, Hanna‐Mari BaldaufList of authors in order
- Landing page
-
https://doi.org/10.3389/fimmu.2024.1303089Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Innate immune system, Cell biology, Biology, Immunity, Function (biology), Expression (computer science), Chemistry, Immunology, Immune system, Computer science, Programming languageTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391320773 |
|---|---|
| doi | https://doi.org/10.3389/fimmu.2024.1303089 |
| ids.doi | https://doi.org/10.3389/fimmu.2024.1303089 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38348040 |
| ids.openalex | https://openalex.org/W4391320773 |
| fwci | 1.4360536 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D011817 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Rabbits |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D051379 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Mice |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D007793 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Lagomorpha |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D002352 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Carrier Proteins |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D019204 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | GTP-Binding Proteins |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D019204 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | GTP-Binding Proteins |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D007113 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Immunity, Innate |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D007372 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Interferons |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000818 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Animals |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D011817 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Rabbits |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D051379 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mice |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D007793 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Lagomorpha |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D002352 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Carrier Proteins |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D019204 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | GTP-Binding Proteins |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D019204 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | GTP-Binding Proteins |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D007113 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Immunity, Innate |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D007372 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Interferons |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000818 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Animals |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D011817 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Rabbits |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D006801 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Humans |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D051379 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Mice |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D007793 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Lagomorpha |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D002352 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Carrier Proteins |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D019204 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | GTP-Binding Proteins |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D019204 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | GTP-Binding Proteins |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D007113 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | Immunity, Innate |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D007372 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Interferons |
| type | article |
| title | Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions |
| biblio.issue | |
| biblio.volume | 15 |
| biblio.last_page | 1303089 |
| biblio.first_page | 1303089 |
| grants[0].funder | https://openalex.org/F4320320879 |
| grants[0].award_id | |
| grants[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| topics[0].id | https://openalex.org/T11668 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | interferon and immune responses |
| topics[1].id | https://openalex.org/T10371 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9987000226974487 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | Immune Response and Inflammation |
| topics[2].id | https://openalex.org/T11597 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9980999827384949 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Neutrophil, Myeloperoxidase and Oxidative Mechanisms |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C136449434 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7873033285140991 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q428253 |
| concepts[0].display_name | Innate immune system |
| concepts[1].id | https://openalex.org/C95444343 |
| concepts[1].level | 1 |
| concepts[1].score | 0.501988410949707 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[1].display_name | Cell biology |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.46504274010658264 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C2779341262 |
| concepts[3].level | 3 |
| concepts[3].score | 0.4522347152233124 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q182581 |
| concepts[3].display_name | Immunity |
| concepts[4].id | https://openalex.org/C14036430 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4310899078845978 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3736076 |
| concepts[4].display_name | Function (biology) |
| concepts[5].id | https://openalex.org/C90559484 |
| concepts[5].level | 2 |
| concepts[5].score | 0.42479994893074036 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q778379 |
| concepts[5].display_name | Expression (computer science) |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.3224753737449646 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.286182701587677 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C8891405 |
| concepts[8].level | 2 |
| concepts[8].score | 0.22967490553855896 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[8].display_name | Immune system |
| concepts[9].id | https://openalex.org/C41008148 |
| concepts[9].level | 0 |
| concepts[9].score | 0.19093239307403564 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[9].display_name | Computer science |
| concepts[10].id | https://openalex.org/C199360897 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q9143 |
| concepts[10].display_name | Programming language |
| keywords[0].id | https://openalex.org/keywords/innate-immune-system |
| keywords[0].score | 0.7873033285140991 |
| keywords[0].display_name | Innate immune system |
| keywords[1].id | https://openalex.org/keywords/cell-biology |
| keywords[1].score | 0.501988410949707 |
| keywords[1].display_name | Cell biology |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.46504274010658264 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/immunity |
| keywords[3].score | 0.4522347152233124 |
| keywords[3].display_name | Immunity |
| keywords[4].id | https://openalex.org/keywords/function |
| keywords[4].score | 0.4310899078845978 |
| keywords[4].display_name | Function (biology) |
| keywords[5].id | https://openalex.org/keywords/expression |
| keywords[5].score | 0.42479994893074036 |
| keywords[5].display_name | Expression (computer science) |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.3224753737449646 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.286182701587677 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/immune-system |
| keywords[8].score | 0.22967490553855896 |
| keywords[8].display_name | Immune system |
| keywords[9].id | https://openalex.org/keywords/computer-science |
| keywords[9].score | 0.19093239307403564 |
| keywords[9].display_name | Computer science |
| language | en |
| locations[0].id | doi:10.3389/fimmu.2024.1303089 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2595292759 |
| locations[0].source.issn | 1664-3224 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-3224 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Immunology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=False |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Immunology |
| locations[0].landing_page_url | https://doi.org/10.3389/fimmu.2024.1303089 |
| locations[1].id | pmid:38348040 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in immunology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38348040 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10859415 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10859415/pdf/fimmu-15-1303089.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Front Immunol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10859415 |
| locations[3].id | pmh:oai:HAL:hal-04934620v1 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Journal articles |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Frontiers in Immunology, 2024, 15, pp.1303089. ⟨10.3389/fimmu.2024.1303089⟩ |
| locations[3].landing_page_url | https://hal.science/hal-04934620 |
| locations[4].id | pmh:oai:doaj.org/article:f9eaed9ec78849db87f66e1c42b9f5e4 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Frontiers in Immunology, Vol 15 (2024) |
| locations[4].landing_page_url | https://doaj.org/article/f9eaed9ec78849db87f66e1c42b9f5e4 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5038867464 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2119-1152 |
| authorships[0].author.display_name | Luca Schelle |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[0].affiliations[0].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I8204097 |
| authorships[0].institutions[0].ror | https://ror.org/05591te55 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Luca Schelle |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[1].author.id | https://openalex.org/A5029685988 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3814-0781 |
| authorships[1].author.display_name | João Vasco Côrte‐Real |
| authorships[1].countries | DE, PT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[1].affiliations[1].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[1].affiliations[2].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I8204097 |
| authorships[1].institutions[0].ror | https://ror.org/05591te55 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[1].institutions[1].id | https://openalex.org/I182534213 |
| authorships[1].institutions[1].ror | https://ror.org/043pwc612 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I182534213 |
| authorships[1].institutions[1].country_code | PT |
| authorships[1].institutions[1].display_name | Universidade do Porto |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | João Vasco Côrte-Real |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal, Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[2].author.id | https://openalex.org/A5005963971 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2386-6793 |
| authorships[2].author.display_name | Sharmeen Fayyaz |
| authorships[2].countries | DE, PK |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210140742 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I193670377 |
| authorships[2].affiliations[1].raw_affiliation_string | National Institute of Virology, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan |
| authorships[2].institutions[0].id | https://openalex.org/I4210140742 |
| authorships[2].institutions[0].ror | https://ror.org/04xqmb911 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210140742 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Institute of Medical Microbiology and Hygiene |
| authorships[2].institutions[1].id | https://openalex.org/I193670377 |
| authorships[2].institutions[1].ror | https://ror.org/05bbbc791 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I193670377 |
| authorships[2].institutions[1].country_code | PK |
| authorships[2].institutions[1].display_name | University of Karachi |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sharmeen Fayyaz |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany, National Institute of Virology, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan |
| authorships[3].author.id | https://openalex.org/A5093813152 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Augusto del Pozo Ben |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[3].affiliations[0].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I8204097 |
| authorships[3].institutions[0].ror | https://ror.org/05591te55 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Augusto del Pozo Ben |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[4].author.id | https://openalex.org/A5048701977 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8336-0113 |
| authorships[4].author.display_name | Margarita Shnipova |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[4].affiliations[0].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[4].institutions[0].id | https://openalex.org/I8204097 |
| authorships[4].institutions[0].ror | https://ror.org/05591te55 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Margarita Shnipova |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[5].author.id | https://openalex.org/A5048052369 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Moritz Petersen |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210140742 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I4210140742 |
| authorships[5].institutions[0].ror | https://ror.org/04xqmb911 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210140742 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Institute of Medical Microbiology and Hygiene |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Moritz Petersen |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[6].author.id | https://openalex.org/A5057449663 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9630-7100 |
| authorships[6].author.display_name | Rishikesh Lotke |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210140742 |
| authorships[6].affiliations[0].raw_affiliation_string | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I4210140742 |
| authorships[6].institutions[0].ror | https://ror.org/04xqmb911 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210140742 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Institute of Medical Microbiology and Hygiene |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Rishikesh Lotke |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[7].author.id | https://openalex.org/A5111698846 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | B. Menon |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[7].affiliations[0].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I8204097 |
| authorships[7].institutions[0].ror | https://ror.org/05591te55 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Bhavna Menon |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[8].author.id | https://openalex.org/A5020085519 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Dana Matzek |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[8].affiliations[0].raw_affiliation_string | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I8204097 |
| authorships[8].institutions[0].ror | https://ror.org/05591te55 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Dana Matzek |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[9].author.id | https://openalex.org/A5093813151 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Lena Pfaff |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[9].affiliations[0].raw_affiliation_string | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[9].institutions[0].id | https://openalex.org/I8204097 |
| authorships[9].institutions[0].ror | https://ror.org/05591te55 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Lena Pfaff |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[10].author.id | https://openalex.org/A5020695330 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-9047-954X |
| authorships[10].author.display_name | Ana Pinheiro |
| authorships[10].countries | PT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[10].affiliations[0].raw_affiliation_string | CIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal |
| authorships[10].affiliations[1].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[10].institutions[0].id | https://openalex.org/I182534213 |
| authorships[10].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[10].institutions[0].country_code | PT |
| authorships[10].institutions[0].display_name | Universidade do Porto |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Ana Pinheiro |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, CIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal |
| authorships[11].author.id | https://openalex.org/A5022221583 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-9834-1361 |
| authorships[11].author.display_name | João Pedro Marques |
| authorships[11].countries | FR, PT |
| authorships[11].affiliations[0].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I159885104, https://openalex.org/I19894307, https://openalex.org/I4210105943, https://openalex.org/I4210166444 |
| authorships[11].affiliations[1].raw_affiliation_string | ISEM, University of Montpellier, CNRS, EPHE, IRD, Montpellier, France |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I182534213 |
| authorships[11].affiliations[2].raw_affiliation_string | CIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal |
| authorships[11].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[11].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[11].institutions[0].type | government |
| authorships[11].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[11].institutions[0].country_code | FR |
| authorships[11].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[11].institutions[1].id | https://openalex.org/I4210166444 |
| authorships[11].institutions[1].ror | https://ror.org/05q3vnk25 |
| authorships[11].institutions[1].type | government |
| authorships[11].institutions[1].lineage | https://openalex.org/I2802818602, https://openalex.org/I4210090127, https://openalex.org/I4210131494, https://openalex.org/I4210166444 |
| authorships[11].institutions[1].country_code | FR |
| authorships[11].institutions[1].display_name | Institut de Recherche pour le Développement |
| authorships[11].institutions[2].id | https://openalex.org/I4210105943 |
| authorships[11].institutions[2].ror | https://ror.org/01cah1n37 |
| authorships[11].institutions[2].type | facility |
| authorships[11].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I131077856, https://openalex.org/I159885104, https://openalex.org/I19894307, https://openalex.org/I2746051580, https://openalex.org/I2802818602, https://openalex.org/I4210090127, https://openalex.org/I4210105943, https://openalex.org/I4210107625, https://openalex.org/I4210131494, https://openalex.org/I4210166444 |
| authorships[11].institutions[2].country_code | FR |
| authorships[11].institutions[2].display_name | Institut des Sciences de l'Evolution de Montpellier |
| authorships[11].institutions[3].id | https://openalex.org/I19894307 |
| authorships[11].institutions[3].ror | https://ror.org/051escj72 |
| authorships[11].institutions[3].type | education |
| authorships[11].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[11].institutions[3].country_code | FR |
| authorships[11].institutions[3].display_name | Université de Montpellier |
| authorships[11].institutions[4].id | https://openalex.org/I159885104 |
| authorships[11].institutions[4].ror | https://ror.org/046b3cj80 |
| authorships[11].institutions[4].type | education |
| authorships[11].institutions[4].lineage | https://openalex.org/I159885104, https://openalex.org/I2746051580 |
| authorships[11].institutions[4].country_code | FR |
| authorships[11].institutions[4].display_name | École Pratique des Hautes Études |
| authorships[11].institutions[5].id | https://openalex.org/I182534213 |
| authorships[11].institutions[5].ror | https://ror.org/043pwc612 |
| authorships[11].institutions[5].type | education |
| authorships[11].institutions[5].lineage | https://openalex.org/I182534213 |
| authorships[11].institutions[5].country_code | PT |
| authorships[11].institutions[5].display_name | Universidade do Porto |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | João Pedro Marques |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, CIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, Vairão, Portugal, ISEM, University of Montpellier, CNRS, EPHE, IRD, Montpellier, France |
| authorships[12].author.id | https://openalex.org/A5002441472 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-4473-1908 |
| authorships[12].author.display_name | José Melo‐Ferreira |
| authorships[12].countries | PT |
| authorships[12].affiliations[0].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I182534213 |
| authorships[12].affiliations[1].raw_affiliation_string | Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[12].institutions[0].id | https://openalex.org/I182534213 |
| authorships[12].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[12].institutions[0].country_code | PT |
| authorships[12].institutions[0].display_name | Universidade do Porto |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | José Melo-Ferreira |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[13].author.id | https://openalex.org/A5020991402 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1517-695X |
| authorships[13].author.display_name | Bastian Popper |
| authorships[13].countries | DE |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[13].affiliations[0].raw_affiliation_string | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[13].institutions[0].id | https://openalex.org/I8204097 |
| authorships[13].institutions[0].ror | https://ror.org/05591te55 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[13].institutions[0].country_code | DE |
| authorships[13].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Bastian Popper |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Biomedical Center (BMC), Core facility Animal Models (CAM), Faculty of Medicine, LMU München, Munich, Germany |
| authorships[14].author.id | https://openalex.org/A5046264937 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-6055-8298 |
| authorships[14].author.display_name | Pedro J. Esteves |
| authorships[14].countries | PT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I182534213 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[14].affiliations[1].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I4210096930 |
| authorships[14].affiliations[2].raw_affiliation_string | CITS - Center of Investigation in Health Technologies, CESPU, Gandra, Portugal |
| authorships[14].institutions[0].id | https://openalex.org/I4210096930 |
| authorships[14].institutions[0].ror | https://ror.org/00w7bj245 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210096930 |
| authorships[14].institutions[0].country_code | PT |
| authorships[14].institutions[0].display_name | Cooperativa de Ensino Superior Politécnico e Universitário |
| authorships[14].institutions[1].id | https://openalex.org/I182534213 |
| authorships[14].institutions[1].ror | https://ror.org/043pwc612 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I182534213 |
| authorships[14].institutions[1].country_code | PT |
| authorships[14].institutions[1].display_name | Universidade do Porto |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Pedro José Esteves |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, CITS - Center of Investigation in Health Technologies, CESPU, Gandra, Portugal, Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[15].author.id | https://openalex.org/A5041471505 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-7665-0040 |
| authorships[15].author.display_name | Daniel Sauter |
| authorships[15].countries | DE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I4210140742 |
| authorships[15].affiliations[0].raw_affiliation_string | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[15].institutions[0].id | https://openalex.org/I4210140742 |
| authorships[15].institutions[0].ror | https://ror.org/04xqmb911 |
| authorships[15].institutions[0].type | facility |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210140742 |
| authorships[15].institutions[0].country_code | DE |
| authorships[15].institutions[0].display_name | Institute of Medical Microbiology and Hygiene |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Daniel Sauter |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany |
| authorships[16].author.id | https://openalex.org/A5023445036 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-8391-7134 |
| authorships[16].author.display_name | Joana Abrantes |
| authorships[16].countries | PT |
| authorships[16].affiliations[0].raw_affiliation_string | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I182534213 |
| authorships[16].affiliations[1].raw_affiliation_string | Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[16].institutions[0].id | https://openalex.org/I182534213 |
| authorships[16].institutions[0].ror | https://ror.org/043pwc612 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I182534213 |
| authorships[16].institutions[0].country_code | PT |
| authorships[16].institutions[0].display_name | Universidade do Porto |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Joana Abrantes |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Vairão, Portugal, Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal |
| authorships[17].author.id | https://openalex.org/A5089278681 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-0589-697X |
| authorships[17].author.display_name | Hanna‐Mari Baldauf |
| authorships[17].countries | DE |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[17].affiliations[0].raw_affiliation_string | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| authorships[17].institutions[0].id | https://openalex.org/I8204097 |
| authorships[17].institutions[0].ror | https://ror.org/05591te55 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[17].institutions[0].country_code | DE |
| authorships[17].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[17].author_position | last |
| authorships[17].raw_author_name | Hanna-Mari Baldauf |
| authorships[17].is_corresponding | True |
| authorships[17].raw_affiliation_strings | Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=False |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11668 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | interferon and immune responses |
| related_works | https://openalex.org/W2066136773, https://openalex.org/W1495541589, https://openalex.org/W2565121077, https://openalex.org/W2130166758, https://openalex.org/W2316042956, https://openalex.org/W1987802636, https://openalex.org/W2158827209, https://openalex.org/W4285733331, https://openalex.org/W3195238582, https://openalex.org/W2190283986 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3389/fimmu.2024.1303089 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2595292759 |
| best_oa_location.source.issn | 1664-3224 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-3224 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Immunology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=False |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Immunology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fimmu.2024.1303089 |
| primary_location.id | doi:10.3389/fimmu.2024.1303089 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2595292759 |
| primary_location.source.issn | 1664-3224 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-3224 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Immunology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1303089/pdf?isPublishedV2=False |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Immunology |
| primary_location.landing_page_url | https://doi.org/10.3389/fimmu.2024.1303089 |
| publication_date | 2024-01-29 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2175065081, https://openalex.org/W2883058246, https://openalex.org/W2464961930, https://openalex.org/W3026095689, https://openalex.org/W2762978092, https://openalex.org/W2341959167, https://openalex.org/W2766729051, https://openalex.org/W2954066482, https://openalex.org/W1987348808, https://openalex.org/W2023882799, https://openalex.org/W2066911876, https://openalex.org/W2981250080, https://openalex.org/W4315866117, https://openalex.org/W4223617065, https://openalex.org/W2037692337, https://openalex.org/W3127109662, https://openalex.org/W4210976557, https://openalex.org/W46079709, https://openalex.org/W2024979811, https://openalex.org/W2330358494, https://openalex.org/W1990300139, https://openalex.org/W2131086619, https://openalex.org/W2009972880, https://openalex.org/W2193512695, https://openalex.org/W2805031563, https://openalex.org/W4295067248, https://openalex.org/W2131203559, https://openalex.org/W3156458251, https://openalex.org/W2061352595, https://openalex.org/W1988986117, https://openalex.org/W2127648442, https://openalex.org/W2125079066, https://openalex.org/W2107158607, https://openalex.org/W1989889573, https://openalex.org/W2701613709, https://openalex.org/W3008127884, https://openalex.org/W3143274236, https://openalex.org/W3120365890, https://openalex.org/W2132261072, https://openalex.org/W1999558098, https://openalex.org/W2945275491, https://openalex.org/W2965830542, https://openalex.org/W2914381860, https://openalex.org/W3111646026, https://openalex.org/W3134196763, https://openalex.org/W2048912867, https://openalex.org/W2128296317, https://openalex.org/W3037348091, https://openalex.org/W1952006670, https://openalex.org/W2080280401, https://openalex.org/W1971405840, https://openalex.org/W2001318826, https://openalex.org/W2963654903, https://openalex.org/W6629003624, https://openalex.org/W2106882534, https://openalex.org/W2799524357, https://openalex.org/W2017519756, https://openalex.org/W3083406432, https://openalex.org/W4281790889, https://openalex.org/W3145012743, https://openalex.org/W1523960441, https://openalex.org/W6673006467, https://openalex.org/W2100303227, https://openalex.org/W2162098634, https://openalex.org/W2089400681, https://openalex.org/W1483247593 |
| referenced_works_count | 66 |
| abstract_inverted_index., | 154 |
| abstract_inverted_index.. | 146, 166 |
| abstract_inverted_index.6 | 143 |
| abstract_inverted_index.7 | 145 |
| abstract_inverted_index.a | 57, 129, 150, 155, 161, 254 |
| abstract_inverted_index.In | 219, 231 |
| abstract_inverted_index.We | 137 |
| abstract_inverted_index.an | 5, 211, 234 |
| abstract_inverted_index.be | 29 |
| abstract_inverted_index.by | 32, 123, 170 |
| abstract_inverted_index.in | 38, 256 |
| abstract_inverted_index.of | 9, 23, 59, 70, 117, 134, 152, 158, 164, 251 |
| abstract_inverted_index.on | 92, 111 |
| abstract_inverted_index.to | 19, 113, 197, 201 |
| abstract_inverted_index.we | 108 |
| abstract_inverted_index.GBP | 76, 120, 184 |
| abstract_inverted_index.and | 25, 47, 62, 85, 94, 127, 131, 144, 160, 178, 207, 225, 242, 245, 248 |
| abstract_inverted_index.are | 4, 12, 36, 99 |
| abstract_inverted_index.can | 28 |
| abstract_inverted_index.for | 66, 104 |
| abstract_inverted_index.our | 115 |
| abstract_inverted_index.the | 20, 39, 67, 118, 198, 202, 215, 246 |
| abstract_inverted_index.GBP2 | 153 |
| abstract_inverted_index.GBP4 | 165 |
| abstract_inverted_index.GBP5 | 159 |
| abstract_inverted_index.GBPs | 35, 55, 191, 238 |
| abstract_inverted_index.Gene | 167 |
| abstract_inverted_index.Most | 72 |
| abstract_inverted_index.They | 17 |
| abstract_inverted_index.data | 180 |
| abstract_inverted_index.four | 221 |
| abstract_inverted_index.from | 233 |
| abstract_inverted_index.gain | 61, 241 |
| abstract_inverted_index.gene | 60, 77 |
| abstract_inverted_index.have | 52, 89 |
| abstract_inverted_index.here | 110 |
| abstract_inverted_index.lack | 141 |
| abstract_inverted_index.loss | 63, 151, 243 |
| abstract_inverted_index.only | 226 |
| abstract_inverted_index.role | 255 |
| abstract_inverted_index.that | 11, 54, 79, 139, 182 |
| abstract_inverted_index.were | 210, 223 |
| abstract_inverted_index.with | 214 |
| abstract_inverted_index.GBP3, | 142 |
| abstract_inverted_index.GBPs. | 96, 136 |
| abstract_inverted_index.Since | 97 |
| abstract_inverted_index.among | 15 |
| abstract_inverted_index.chain | 175 |
| abstract_inverted_index.focus | 109 |
| abstract_inverted_index.furin | 229 |
| abstract_inverted_index.human | 95, 106 |
| abstract_inverted_index.large | 75 |
| abstract_inverted_index.model | 69, 102 |
| abstract_inverted_index.ocGBP | 252 |
| abstract_inverted_index.shown | 53 |
| abstract_inverted_index.their | 26 |
| abstract_inverted_index.viral | 48 |
| abstract_inverted_index.(GBPs) | 3 |
| abstract_inverted_index.(TGN). | 218 |
| abstract_inverted_index.across | 187 |
| abstract_inverted_index.and/or | 195, 200 |
| abstract_inverted_index.belong | 18 |
| abstract_inverted_index.either | 193 |
| abstract_inverted_index.encode | 80 |
| abstract_inverted_index.family | 8, 122 |
| abstract_inverted_index.harbor | 74 |
| abstract_inverted_index.immune | 42 |
| abstract_inverted_index.innate | 41, 257 |
| abstract_inverted_index.mainly | 90 |
| abstract_inverted_index.murine | 93 |
| abstract_inverted_index.ocGBPs | 222 |
| abstract_inverted_index.rabbit | 135, 190 |
| abstract_inverted_index.rarely | 208 |
| abstract_inverted_index.system | 103 |
| abstract_inverted_index.unique | 156 |
| abstract_inverted_index.varied | 186 |
| abstract_inverted_index.widely | 13 |
| abstract_inverted_index.(IFNs). | 34 |
| abstract_inverted_index.against | 44 |
| abstract_inverted_index.ancient | 7 |
| abstract_inverted_index.another | 100 |
| abstract_inverted_index.binding | 1 |
| abstract_inverted_index.broaden | 114 |
| abstract_inverted_index.dynamin | 21 |
| abstract_inverted_index.events, | 64, 244 |
| abstract_inverted_index.exhibit | 56 |
| abstract_inverted_index.focused | 91 |
| abstract_inverted_index.induced | 31 |
| abstract_inverted_index.leporid | 183 |
| abstract_inverted_index.massive | 162 |
| abstract_inverted_index.network | 217 |
| abstract_inverted_index.pattern | 58 |
| abstract_inverted_index.protein | 121 |
| abstract_inverted_index.rabbits | 98 |
| abstract_inverted_index.reverse | 171 |
| abstract_inverted_index.species | 73 |
| abstract_inverted_index.studies | 51, 88 |
| abstract_inverted_index.suggest | 253 |
| abstract_inverted_index.GTPases, | 24 |
| abstract_inverted_index.Previous | 83 |
| abstract_inverted_index.analyses | 126 |
| abstract_inverted_index.analysis | 169 |
| abstract_inverted_index.clusters | 78 |
| abstract_inverted_index.in-depth | 86 |
| abstract_inverted_index.involved | 37 |
| abstract_inverted_index.multiple | 81, 240 |
| abstract_inverted_index.nucleus. | 203 |
| abstract_inverted_index.observed | 138 |
| abstract_inverted_index.ocGBP5L2 | 209, 227 |
| abstract_inverted_index.proteins | 2, 10 |
| abstract_inverted_index.reaction | 176 |
| abstract_inverted_index.response | 43 |
| abstract_inverted_index.revealed | 181 |
| abstract_inverted_index.studying | 105 |
| abstract_inverted_index.tissues. | 188 |
| abstract_inverted_index.(RT-qPCR) | 177 |
| abstract_inverted_index.Guanylate | 0 |
| abstract_inverted_index.Leporidae | 148 |
| abstract_inverted_index.activity. | 230 |
| abstract_inverted_index.addition, | 220 |
| abstract_inverted_index.cuniculus | 205 |
| abstract_inverted_index.cytoplasm | 199 |
| abstract_inverted_index.diseases, | 107 |
| abstract_inverted_index.expansion | 163 |
| abstract_inverted_index.immunity. | 258 |
| abstract_inverted_index.important | 101 |
| abstract_inverted_index.inhibited | 228 |
| abstract_inverted_index.lagomorph | 237 |
| abstract_inverted_index.localized | 192 |
| abstract_inverted_index.molecular | 130, 247 |
| abstract_inverted_index.paralogs. | 82 |
| abstract_inverted_index.parasitic | 46 |
| abstract_inverted_index.partially | 30 |
| abstract_inverted_index.uniformly | 194 |
| abstract_inverted_index.(oc)GBP5L1 | 206 |
| abstract_inverted_index.bacterial, | 45 |
| abstract_inverted_index.conducting | 124 |
| abstract_inverted_index.discretely | 196 |
| abstract_inverted_index.evolution. | 71 |
| abstract_inverted_index.exception, | 212 |
| abstract_inverted_index.expression | 27, 168, 185 |
| abstract_inverted_index.functional | 84, 132, 249 |
| abstract_inverted_index.indicative | 65 |
| abstract_inverted_index.lagomorphs | 112, 140 |
| abstract_inverted_index.performing | 128 |
| abstract_inverted_index.polymerase | 174 |
| abstract_inverted_index.Oryctolagus | 204 |
| abstract_inverted_index.conclusion, | 232 |
| abstract_inverted_index.distributed | 14 |
| abstract_inverted_index.duplication | 157 |
| abstract_inverted_index.eukaryotes. | 16 |
| abstract_inverted_index.experienced | 149, 239 |
| abstract_inverted_index.infections. | 49 |
| abstract_inverted_index.interferons | 33 |
| abstract_inverted_index.superfamily | 22 |
| abstract_inverted_index.trans-Golgi | 216 |
| abstract_inverted_index.Evolutionary | 50 |
| abstract_inverted_index.Furthermore, | 147 |
| abstract_inverted_index.colocalizing | 213 |
| abstract_inverted_index.evolutionary | 87, 125, 235 |
| abstract_inverted_index.perspective, | 236 |
| abstract_inverted_index.quantitative | 173 |
| abstract_inverted_index.IFN-inducible | 224 |
| abstract_inverted_index.Overexpressed | 189 |
| abstract_inverted_index.transcriptase | 172 |
| abstract_inverted_index.transcriptome | 179 |
| abstract_inverted_index.understanding | 116 |
| abstract_inverted_index.evolutionarily | 6 |
| abstract_inverted_index.birth-and-death | 68 |
| abstract_inverted_index.cell-autonomous | 40 |
| abstract_inverted_index.characteristics | 250 |
| abstract_inverted_index.multifunctional | 119 |
| abstract_inverted_index.characterization | 133 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5089278681, https://openalex.org/A5023445036 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I182534213, https://openalex.org/I8204097 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.7266043 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |