Ex situ perfusion fixation for brain banking: a technical report Article Swipe
Andrew McKenzie
,
Emma Woodoff‐Leith
,
Diana K. Dangoor
,
Alessandra Cervera
,
Hadley W. Ressler
,
Kristen Whitney
,
Kristen Dams-O’Connor
,
Zhuhao Wu
,
Elizabeth M. C. Hillman
,
Alan C. Seifert
,
John F. Crary
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.17879/freeneuropathology-2022-4368
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.17879/freeneuropathology-2022-4368
Perfusion fixation is a well-established technique in animal research to improve preservation quality in the study of many tissues, including the brain. There is a growing interest in using perfusion to fix postmortem human brain tissue to achieve the highest fidelity preservation for downstream high-resolution morphomolecular brain mapping studies. Numerous practical barriers arise when applying perfusion fixation in brain banking settings, including the large mass of the organ, degradation of vascular integrity and patency prior to the start of the procedure, and differing investigator goals sometimes necessitating part of the brain to be frozen. As a result, there is a critical need to establish a perfusion fixation procedure in brain banking that is flexible and scalable. This technical report describes our approach to developing an ex situ perfusion fixation protocol. We discuss the challenges encountered and lessons learned while implementing this procedure. Routine morphological staining and RNA in situ hybridization data show that the perfused brains have well-preserved tissue cytoarchitecture and intact biomolecular signal. However, it remains uncertain whether this procedure leads to improved histology quality compared to immersion fixation. Additionally, ex vivo magnetic resonance imaging (MRI) data suggest that the perfusion fixation protocol may introduce imaging artifacts in the form of air bubbles in the vasculature. We conclude with further research directions to investigate the use of perfusion fixation as a rigorous and reproducible alternative to immersion fixation for the preparation of postmortem human brains.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/37284166
- OA Status
- green
- Cited By
- 10
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379600492
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379600492Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.17879/freeneuropathology-2022-4368Digital Object Identifier
- Title
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Ex situ perfusion fixation for brain banking: a technical reportWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-15Full publication date if available
- Authors
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Andrew McKenzie, Emma Woodoff‐Leith, Diana K. Dangoor, Alessandra Cervera, Hadley W. Ressler, Kristen Whitney, Kristen Dams-O’Connor, Zhuhao Wu, Elizabeth M. C. Hillman, Alan C. Seifert, John F. CraryList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/37284166Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10209847/pdf/freeneuropathol-03-22-4368.pdfDirect OA link when available
- Concepts
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Fixation (population genetics), Ex vivo, Perfusion, In situ, Perfusion scanning, In situ hybridization, Biomedical engineering, Medicine, Pathology, Biology, In vivo, Radiology, Chemistry, Biotechnology, Organic chemistry, Gene, Gene expression, Biochemistry, Population, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 5, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.as | 220 |
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| abstract_inverted_index.while | 138 |
| abstract_inverted_index.animal | 7 |
| abstract_inverted_index.brain. | 21 |
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| abstract_inverted_index.intact | 161 |
| abstract_inverted_index.organ, | 67 |
| abstract_inverted_index.report | 118 |
| abstract_inverted_index.tissue | 35, 158 |
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| abstract_inverted_index.banking | 59, 110 |
| abstract_inverted_index.brains. | 235 |
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| abstract_inverted_index.However, | 164 |
| abstract_inverted_index.Numerous | 49 |
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| abstract_inverted_index.conclude | 208 |
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| abstract_inverted_index.fidelity | 40 |
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| abstract_inverted_index.Perfusion | 0 |
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| citation_normalized_percentile.is_in_top_10_percent | False |