Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials Article Swipe
Kevin E. Boczar
,
Sheojung Shin
,
Kathryn Bezzina
,
Aishwarya Geejo
,
Alexander Pearson
,
Saba Shahab
,
Christophe A. Fehlmann
,
Sarah Visintini
,
Rob Beanlands
,
George A. Wells
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2022-062702
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2022-062702
Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents. However, comparative evidence regarding efficacy of these anti-inflammatory treatment options is currently lacking. Methods and analysis This systematic review will include randomised controlled trials evaluating the effect of anti-inflammatory agents on cardiovascular outcomes in patients with known cardiovascular disease. Studies will be retrieved from Medline, Embase, the Cochrane Central Register of Controlled Trials, as well as clinical trial registry websites, Europe PMC and conference abstract handsearching. No publication date or language restrictions will be imposed. Eligible interventions must have some component of anti-inflammatory agent. These include (but are not limited to): non-steroidal anti-inflammatory drugs (NSAIDs), colchicine, prednisone, methotrexate, canakinumab, pexelizumab, anakinra, succinobucol, losmapimod, inclacumab, atreleuton, LP-PLA 2 (darapladib) and sPLA 2 (varespladib). The primary outcomes will include major adverse cardiac events (MACE), and each individual component of MACE (myocardial infarction, stroke and cardiovascular death). Key secondary outcomes will include unstable angina, heart failure, all-cause mortality, cardiac arrest and revascularisation. Screening, inclusion, data extraction and quality assessment will be performed independently by two reviewers. Network meta-analysis based on the random effects model will be conducted to compare treatment effects both directly and indirectly. The quality of the evidence will be assessed with appropriate tools including the Grading of Recommendations, Assessment, Development and Evaluation profiler or Confidence in Network Meta-Analysis tool. Ethics and dissemination Ethics approval is not required for this systematic review. The findings will be disseminated through a peer-reviewed journal. PROSPERO registration number CRD42022303289.
Related Topics
Concepts
Medicine
Mace
Canakinumab
Systematic review
Intensive care medicine
Meta-analysis
Randomized controlled trial
Acute coronary syndrome
Myocardial infarction
MEDLINE
Anakinra
Stroke (engine)
Clinical trial
Disease
Internal medicine
Physical therapy
Percutaneous coronary intervention
Mechanical engineering
Engineering
Law
Political science
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2022-062702
- https://bmjopen.bmj.com/content/bmjopen/12/6/e062702.full.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283589955
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4283589955Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2022-062702Digital Object Identifier
- Title
-
Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trialsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-01Full publication date if available
- Authors
-
Kevin E. Boczar, Sheojung Shin, Kathryn Bezzina, Aishwarya Geejo, Alexander Pearson, Saba Shahab, Christophe A. Fehlmann, Sarah Visintini, Rob Beanlands, George A. WellsList of authors in order
- Landing page
-
https://doi.org/10.1136/bmjopen-2022-062702Publisher landing page
- PDF URL
-
https://bmjopen.bmj.com/content/bmjopen/12/6/e062702.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://bmjopen.bmj.com/content/bmjopen/12/6/e062702.full.pdfDirect OA link when available
- Concepts
-
Medicine, Mace, Canakinumab, Systematic review, Intensive care medicine, Meta-analysis, Randomized controlled trial, Acute coronary syndrome, Myocardial infarction, MEDLINE, Anakinra, Stroke (engine), Clinical trial, Disease, Internal medicine, Physical therapy, Percutaneous coronary intervention, Mechanical engineering, Engineering, Law, Political scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
28Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5089990559 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I153718931 |
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| citation_normalized_percentile.is_in_top_10_percent | False |