Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in theUbe3aDeletion Rat Model of Angelman Syndrome Article Swipe
Elizabeth L. Berg
,
Shekib A. Jami
,
Stela P. Petkova
,
Annuska Berz
,
Timothy A. Fenton
,
Jason P. Lerch
,
David J. Segal
,
J.A. Gray
,
Jacob Ellegood
,
Markus Wöhr
,
Jill L. Silverman
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1523/jneurosci.0925-21.2021
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1523/jneurosci.0925-21.2021
Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder characterized by intellectual disabilities, motor and balance deficits, impaired communication, and a happy, excitable demeanor with frequent laughter. We sought to elucidate a preclinical outcome measure in male and female rats that addressed communication abnormalities of AS and other neurodevelopmental disorders in which communication is atypical and/or lack of speech is a core feature. We discovered, and herein report for the first time, excessive laughter-like 50 kHz ultrasonic emissions in the Ube3a mat–/pat+ rat model of AS, which suggests an excitable, playful demeanor and elevated positive affect, similar to the demeanor of individuals with AS. Also in line with the AS phenotype, Ube3a mat–/pat+ rats demonstrated aberrant social interactions with a novel partner, distinctive gait abnormalities, impaired cognition, an underlying LTP deficit, and profound reductions in brain volume. These unique, robust phenotypes provide advantages compared with currently available mouse models and will be highly valuable as outcome measures in the evaluation of therapies for AS. SIGNIFICANCE STATEMENT Angelman syndrome (AS) is a severe neurogenetic disorder for which there is no cure, despite decades of research using mouse models. This study used a recently developed rat model of AS to delineate disease-relevant outcome measures to facilitate therapeutic development. We found the rat to be a strong model of AS, offering several advantages over mouse models by exhibiting numerous AS-relevant phenotypes, including overabundant laughter-like vocalizations, reduced hippocampal LTP, and volumetric anomalies across the brain. These findings are unconfounded by detrimental motor abilities and background strain, issues plaguing mouse models. This rat model represents an important advancement in the field of AS, and the outcome metrics reported herein will be central to the therapeutic pipeline.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1523/jneurosci.0925-21.2021
- https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdf
- OA Status
- bronze
- Cited By
- 22
- References
- 113
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3196779067
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3196779067Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1523/jneurosci.0925-21.2021Digital Object Identifier
- Title
-
Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in theUbe3aDeletion Rat Model of Angelman SyndromeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-02Full publication date if available
- Authors
-
Elizabeth L. Berg, Shekib A. Jami, Stela P. Petkova, Annuska Berz, Timothy A. Fenton, Jason P. Lerch, David J. Segal, J.A. Gray, Jacob Ellegood, Markus Wöhr, Jill L. SilvermanList of authors in order
- Landing page
-
https://doi.org/10.1523/jneurosci.0925-21.2021Publisher landing page
- PDF URL
-
https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdfDirect OA link when available
- Concepts
-
Laughter, Angelman syndrome, UBE3A, Neuroscience, Psychology, Neurodevelopmental disorder, Intellectual disability, Microcephaly, Disease, Phenotype, Fragile X syndrome, Developmental psychology, Medicine, Autism, Biology, Psychiatry, Genetics, Pathology, Ubiquitin, Ubiquitin ligase, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2023: 4, 2022: 8, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
113Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3196779067 |
|---|---|
| doi | https://doi.org/10.1523/jneurosci.0925-21.2021 |
| ids.doi | https://doi.org/10.1523/jneurosci.0925-21.2021 |
| ids.mag | 3196779067 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34475199 |
| ids.openalex | https://openalex.org/W3196779067 |
| fwci | 2.43390638 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D017204 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Angelman Syndrome |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D017204 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Angelman Syndrome |
| mesh[2].qualifier_ui | Q000523 |
| mesh[2].descriptor_ui | D017204 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | psychology |
| mesh[2].descriptor_name | Angelman Syndrome |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000818 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Animals |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D001921 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Brain |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D004195 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Disease Models, Animal |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D005260 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Female |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D017353 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Gene Deletion |
| mesh[8].qualifier_ui | Q000502 |
| mesh[8].descriptor_ui | D007845 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | physiology |
| mesh[8].descriptor_name | Laughter |
| mesh[9].qualifier_ui | Q000523 |
| mesh[9].descriptor_ui | D007845 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | psychology |
| mesh[9].descriptor_name | Laughter |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008297 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Male |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D008831 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Microcephaly |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D008831 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Microcephaly |
| mesh[13].qualifier_ui | Q000523 |
| mesh[13].descriptor_ui | D008831 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | psychology |
| mesh[13].descriptor_name | Microcephaly |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D009924 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Organ Culture Techniques |
| mesh[15].qualifier_ui | Q000502 |
| mesh[15].descriptor_ui | D014176 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | physiology |
| mesh[15].descriptor_name | Protein Biosynthesis |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D051381 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Rats |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D017207 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Rats, Sprague-Dawley |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D055647 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Rats, Transgenic |
| mesh[19].qualifier_ui | Q000502 |
| mesh[19].descriptor_ui | D013216 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | physiology |
| mesh[19].descriptor_name | Reflex, Startle |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D012919 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Social Behavior |
| mesh[21].qualifier_ui | Q000172 |
| mesh[21].descriptor_ui | D044767 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | deficiency |
| mesh[21].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[22].qualifier_ui | Q000235 |
| mesh[22].descriptor_ui | D044767 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | genetics |
| mesh[22].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[23].qualifier_ui | Q000502 |
| mesh[23].descriptor_ui | D014828 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | physiology |
| mesh[23].descriptor_name | Vocalization, Animal |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D017204 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Angelman Syndrome |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D017204 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Angelman Syndrome |
| mesh[26].qualifier_ui | Q000523 |
| mesh[26].descriptor_ui | D017204 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | psychology |
| mesh[26].descriptor_name | Angelman Syndrome |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000818 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Animals |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D001921 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Brain |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D004195 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Disease Models, Animal |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D005260 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Female |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D017353 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Gene Deletion |
| mesh[32].qualifier_ui | Q000502 |
| mesh[32].descriptor_ui | D007845 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | physiology |
| mesh[32].descriptor_name | Laughter |
| mesh[33].qualifier_ui | Q000523 |
| mesh[33].descriptor_ui | D007845 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | psychology |
| mesh[33].descriptor_name | Laughter |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D008297 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Male |
| mesh[35].qualifier_ui | Q000235 |
| mesh[35].descriptor_ui | D008831 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | genetics |
| mesh[35].descriptor_name | Microcephaly |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D008831 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Microcephaly |
| mesh[37].qualifier_ui | Q000523 |
| mesh[37].descriptor_ui | D008831 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | psychology |
| mesh[37].descriptor_name | Microcephaly |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D009924 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Organ Culture Techniques |
| mesh[39].qualifier_ui | Q000502 |
| mesh[39].descriptor_ui | D014176 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | physiology |
| mesh[39].descriptor_name | Protein Biosynthesis |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D051381 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Rats |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D017207 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Rats, Sprague-Dawley |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D055647 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Rats, Transgenic |
| mesh[43].qualifier_ui | Q000502 |
| mesh[43].descriptor_ui | D013216 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | physiology |
| mesh[43].descriptor_name | Reflex, Startle |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D012919 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Social Behavior |
| mesh[45].qualifier_ui | Q000172 |
| mesh[45].descriptor_ui | D044767 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | deficiency |
| mesh[45].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[46].qualifier_ui | Q000235 |
| mesh[46].descriptor_ui | D044767 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | genetics |
| mesh[46].descriptor_name | Ubiquitin-Protein Ligases |
| mesh[47].qualifier_ui | Q000502 |
| mesh[47].descriptor_ui | D014828 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | physiology |
| mesh[47].descriptor_name | Vocalization, Animal |
| type | article |
| title | Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in theUbe3aDeletion Rat Model of Angelman Syndrome |
| biblio.issue | 42 |
| biblio.volume | 41 |
| biblio.last_page | 8814 |
| biblio.first_page | 8801 |
| grants[0].funder | https://openalex.org/F4320310859 |
| grants[0].award_id | |
| grants[0].funder_display_name | Ontario Brain Institute |
| grants[1].funder | https://openalex.org/F4320311493 |
| grants[1].award_id | |
| grants[1].funder_display_name | Foundation for Angelman Syndrome Therapeutics |
| grants[2].funder | https://openalex.org/F4320320879 |
| grants[2].award_id | WO 1732/4-2 |
| grants[2].funder_display_name | Deutsche Forschungsgemeinschaft |
| grants[3].funder | https://openalex.org/F4320334506 |
| grants[3].award_id | |
| grants[3].funder_display_name | Canadian Institutes of Health Research |
| grants[4].funder | https://openalex.org/F4320337346 |
| grants[4].award_id | NIMH R01MH117130 |
| grants[4].funder_display_name | National Institute of Mental Health |
| topics[0].id | https://openalex.org/T11928 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Genetic Syndromes and Imprinting |
| topics[1].id | https://openalex.org/T10515 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.946399986743927 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer-related molecular mechanisms research |
| topics[2].id | https://openalex.org/T11482 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9448999762535095 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | RNA modifications and cancer |
| funders[0].id | https://openalex.org/F4320310859 |
| funders[0].ror | https://ror.org/05ecdew94 |
| funders[0].display_name | Ontario Brain Institute |
| funders[1].id | https://openalex.org/F4320311493 |
| funders[1].ror | https://ror.org/00e82pm13 |
| funders[1].display_name | Foundation for Angelman Syndrome Therapeutics |
| funders[2].id | https://openalex.org/F4320320879 |
| funders[2].ror | https://ror.org/018mejw64 |
| funders[2].display_name | Deutsche Forschungsgemeinschaft |
| funders[3].id | https://openalex.org/F4320334506 |
| funders[3].ror | https://ror.org/01gavpb45 |
| funders[3].display_name | Canadian Institutes of Health Research |
| funders[4].id | https://openalex.org/F4320337346 |
| funders[4].ror | https://ror.org/04xeg9z08 |
| funders[4].display_name | National Institute of Mental Health |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2780775679 |
| concepts[0].level | 2 |
| concepts[0].score | 0.9128415584564209 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q170579 |
| concepts[0].display_name | Laughter |
| concepts[1].id | https://openalex.org/C2778691456 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8539136648178101 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q535364 |
| concepts[1].display_name | Angelman syndrome |
| concepts[2].id | https://openalex.org/C2777041782 |
| concepts[2].level | 5 |
| concepts[2].score | 0.8075146079063416 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14878336 |
| concepts[2].display_name | UBE3A |
| concepts[3].id | https://openalex.org/C169760540 |
| concepts[3].level | 1 |
| concepts[3].score | 0.626489520072937 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[3].display_name | Neuroscience |
| concepts[4].id | https://openalex.org/C15744967 |
| concepts[4].level | 0 |
| concepts[4].score | 0.6067683696746826 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[4].display_name | Psychology |
| concepts[5].id | https://openalex.org/C2779388368 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5430731773376465 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3450985 |
| concepts[5].display_name | Neurodevelopmental disorder |
| concepts[6].id | https://openalex.org/C551499885 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5177316069602966 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q183560 |
| concepts[6].display_name | Intellectual disability |
| concepts[7].id | https://openalex.org/C2776395126 |
| concepts[7].level | 2 |
| concepts[7].score | 0.5089037418365479 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q431643 |
| concepts[7].display_name | Microcephaly |
| concepts[8].id | https://openalex.org/C2779134260 |
| concepts[8].level | 2 |
| concepts[8].score | 0.48140883445739746 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[8].display_name | Disease |
| concepts[9].id | https://openalex.org/C127716648 |
| concepts[9].level | 3 |
| concepts[9].score | 0.43676233291625977 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[9].display_name | Phenotype |
| concepts[10].id | https://openalex.org/C2777630245 |
| concepts[10].level | 2 |
| concepts[10].score | 0.42419230937957764 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q221472 |
| concepts[10].display_name | Fragile X syndrome |
| concepts[11].id | https://openalex.org/C138496976 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3221905827522278 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q175002 |
| concepts[11].display_name | Developmental psychology |
| concepts[12].id | https://openalex.org/C71924100 |
| concepts[12].level | 0 |
| concepts[12].score | 0.2963288128376007 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[12].display_name | Medicine |
| concepts[13].id | https://openalex.org/C205778803 |
| concepts[13].level | 2 |
| concepts[13].score | 0.22445178031921387 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q38404 |
| concepts[13].display_name | Autism |
| concepts[14].id | https://openalex.org/C86803240 |
| concepts[14].level | 0 |
| concepts[14].score | 0.1967778205871582 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[14].display_name | Biology |
| concepts[15].id | https://openalex.org/C118552586 |
| concepts[15].level | 1 |
| concepts[15].score | 0.14472007751464844 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[15].display_name | Psychiatry |
| concepts[16].id | https://openalex.org/C54355233 |
| concepts[16].level | 1 |
| concepts[16].score | 0.12843790650367737 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[16].display_name | Genetics |
| concepts[17].id | https://openalex.org/C142724271 |
| concepts[17].level | 1 |
| concepts[17].score | 0.108929842710495 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[17].display_name | Pathology |
| concepts[18].id | https://openalex.org/C25602115 |
| concepts[18].level | 3 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q407111 |
| concepts[18].display_name | Ubiquitin |
| concepts[19].id | https://openalex.org/C134459356 |
| concepts[19].level | 4 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q4274835 |
| concepts[19].display_name | Ubiquitin ligase |
| concepts[20].id | https://openalex.org/C104317684 |
| concepts[20].level | 2 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[20].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/laughter |
| keywords[0].score | 0.9128415584564209 |
| keywords[0].display_name | Laughter |
| keywords[1].id | https://openalex.org/keywords/angelman-syndrome |
| keywords[1].score | 0.8539136648178101 |
| keywords[1].display_name | Angelman syndrome |
| keywords[2].id | https://openalex.org/keywords/ube3a |
| keywords[2].score | 0.8075146079063416 |
| keywords[2].display_name | UBE3A |
| keywords[3].id | https://openalex.org/keywords/neuroscience |
| keywords[3].score | 0.626489520072937 |
| keywords[3].display_name | Neuroscience |
| keywords[4].id | https://openalex.org/keywords/psychology |
| keywords[4].score | 0.6067683696746826 |
| keywords[4].display_name | Psychology |
| keywords[5].id | https://openalex.org/keywords/neurodevelopmental-disorder |
| keywords[5].score | 0.5430731773376465 |
| keywords[5].display_name | Neurodevelopmental disorder |
| keywords[6].id | https://openalex.org/keywords/intellectual-disability |
| keywords[6].score | 0.5177316069602966 |
| keywords[6].display_name | Intellectual disability |
| keywords[7].id | https://openalex.org/keywords/microcephaly |
| keywords[7].score | 0.5089037418365479 |
| keywords[7].display_name | Microcephaly |
| keywords[8].id | https://openalex.org/keywords/disease |
| keywords[8].score | 0.48140883445739746 |
| keywords[8].display_name | Disease |
| keywords[9].id | https://openalex.org/keywords/phenotype |
| keywords[9].score | 0.43676233291625977 |
| keywords[9].display_name | Phenotype |
| keywords[10].id | https://openalex.org/keywords/fragile-x-syndrome |
| keywords[10].score | 0.42419230937957764 |
| keywords[10].display_name | Fragile X syndrome |
| keywords[11].id | https://openalex.org/keywords/developmental-psychology |
| keywords[11].score | 0.3221905827522278 |
| keywords[11].display_name | Developmental psychology |
| keywords[12].id | https://openalex.org/keywords/medicine |
| keywords[12].score | 0.2963288128376007 |
| keywords[12].display_name | Medicine |
| keywords[13].id | https://openalex.org/keywords/autism |
| keywords[13].score | 0.22445178031921387 |
| keywords[13].display_name | Autism |
| keywords[14].id | https://openalex.org/keywords/biology |
| keywords[14].score | 0.1967778205871582 |
| keywords[14].display_name | Biology |
| keywords[15].id | https://openalex.org/keywords/psychiatry |
| keywords[15].score | 0.14472007751464844 |
| keywords[15].display_name | Psychiatry |
| keywords[16].id | https://openalex.org/keywords/genetics |
| keywords[16].score | 0.12843790650367737 |
| keywords[16].display_name | Genetics |
| keywords[17].id | https://openalex.org/keywords/pathology |
| keywords[17].score | 0.108929842710495 |
| keywords[17].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.1523/jneurosci.0925-21.2021 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S5555990 |
| locations[0].source.issn | 0270-6474, 1529-2401 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0270-6474 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Neuroscience |
| locations[0].source.host_organization | https://openalex.org/P4310319739 |
| locations[0].source.host_organization_name | Society for Neuroscience |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319739 |
| locations[0].license | |
| locations[0].pdf_url | https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | The Journal of Neuroscience |
| locations[0].landing_page_url | https://doi.org/10.1523/jneurosci.0925-21.2021 |
| locations[1].id | pmid:34475199 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34475199 |
| locations[2].id | pmh:oai:lirias2repo.kuleuven.be:20.500.12942/687994 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401954 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Lirias (KU Leuven) |
| locations[2].source.host_organization | https://openalex.org/I99464096 |
| locations[2].source.host_organization_name | KU Leuven |
| locations[2].source.host_organization_lineage | https://openalex.org/I99464096 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://lirias.kuleuven.be/handle/20.500.12942/687994 |
| locations[3].id | pmh:oai:escholarship.org:ark:/13030/qt8fz2b3z9 |
| locations[3].is_oa | False |
| locations[3].source | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Journal of Neuroscience, vol 41, iss 42 |
| locations[3].landing_page_url | https://escholarship.org/uc/item/8fz2b3z9 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8528495 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | J Neurosci |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8528495 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5087624798 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6413-2561 |
| authorships[0].author.display_name | Elizabeth L. Berg |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[0].affiliations[0].raw_affiliation_string | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[0].institutions[0].id | https://openalex.org/I84218800 |
| authorships[0].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of California, Davis |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Elizabeth L. Berg |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[1].author.id | https://openalex.org/A5049286655 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5478-1963 |
| authorships[1].author.display_name | Shekib A. Jami |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[1].affiliations[0].raw_affiliation_string | 2Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California 95618 |
| authorships[1].institutions[0].id | https://openalex.org/I84218800 |
| authorships[1].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of California, Davis |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Shekib A. Jami |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | 2Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California 95618 |
| authorships[2].author.id | https://openalex.org/A5042788701 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2700-184X |
| authorships[2].author.display_name | Stela P. Petkova |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[2].affiliations[0].raw_affiliation_string | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[2].institutions[0].id | https://openalex.org/I84218800 |
| authorships[2].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of California, Davis |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Stela P. Petkova |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[3].author.id | https://openalex.org/A5019860209 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5522-0188 |
| authorships[3].author.display_name | Annuska Berz |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I161103922 |
| authorships[3].affiliations[0].raw_affiliation_string | 3Behavioral Neuroscience, Experimental and Biological Psychology, Faculty of Psychology, Philipps-University Marburg, Marburg, 35032, Germany |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I161103922 |
| authorships[3].affiliations[1].raw_affiliation_string | 4Center for Mind, Brain and Behavior, Philipps-University Marburg, Marburg, 35032, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I161103922 |
| authorships[3].institutions[0].ror | https://ror.org/01rdrb571 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I161103922 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Philipps University of Marburg |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Annuska Berz |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | 3Behavioral Neuroscience, Experimental and Biological Psychology, Faculty of Psychology, Philipps-University Marburg, Marburg, 35032, Germany, 4Center for Mind, Brain and Behavior, Philipps-University Marburg, Marburg, 35032, Germany |
| authorships[4].author.id | https://openalex.org/A5042685752 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0269-4328 |
| authorships[4].author.display_name | Timothy A. Fenton |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[4].affiliations[0].raw_affiliation_string | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[4].institutions[0].id | https://openalex.org/I84218800 |
| authorships[4].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of California, Davis |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Timothy A. Fenton |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[5].author.id | https://openalex.org/A5054476201 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6164-2881 |
| authorships[5].author.display_name | Jason P. Lerch |
| authorships[5].countries | CA, GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I185261750 |
| authorships[5].affiliations[0].raw_affiliation_string | 6Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S, Canada |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I40120149, https://openalex.org/I4210101881 |
| authorships[5].affiliations[1].raw_affiliation_string | 7Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, United Kingdom |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I2801317318 |
| authorships[5].affiliations[2].raw_affiliation_string | 5Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada |
| authorships[5].institutions[0].id | https://openalex.org/I2801317318 |
| authorships[5].institutions[0].ror | https://ror.org/057q4rt57 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2801317318 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | Hospital for Sick Children |
| authorships[5].institutions[1].id | https://openalex.org/I185261750 |
| authorships[5].institutions[1].ror | https://ror.org/03dbr7087 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I185261750 |
| authorships[5].institutions[1].country_code | CA |
| authorships[5].institutions[1].display_name | University of Toronto |
| authorships[5].institutions[2].id | https://openalex.org/I40120149 |
| authorships[5].institutions[2].ror | https://ror.org/052gg0110 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I40120149 |
| authorships[5].institutions[2].country_code | GB |
| authorships[5].institutions[2].display_name | University of Oxford |
| authorships[5].institutions[3].id | https://openalex.org/I4210101881 |
| authorships[5].institutions[3].ror | https://ror.org/0172mzb45 |
| authorships[5].institutions[3].type | facility |
| authorships[5].institutions[3].lineage | https://openalex.org/I40120149, https://openalex.org/I4210101881, https://openalex.org/I87048295 |
| authorships[5].institutions[3].country_code | GB |
| authorships[5].institutions[3].display_name | Wellcome Centre for Integrative Neuroimaging |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jason P. Lerch |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | 5Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada, 6Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S, Canada, 7Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, United Kingdom |
| authorships[6].author.id | https://openalex.org/A5089092085 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-8962-3105 |
| authorships[6].author.display_name | David J. Segal |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[6].affiliations[0].raw_affiliation_string | 8MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California 95616 |
| authorships[6].institutions[0].id | https://openalex.org/I84218800 |
| authorships[6].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of California, Davis |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | David J. Segal |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | 8MIND Institute, Genome Center, and Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California 95616 |
| authorships[7].author.id | https://openalex.org/A5102947423 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7287-0748 |
| authorships[7].author.display_name | J.A. Gray |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[7].affiliations[0].raw_affiliation_string | 2Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California 95618 |
| authorships[7].institutions[0].id | https://openalex.org/I84218800 |
| authorships[7].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of California, Davis |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | John A. Gray |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | 2Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California 95618 |
| authorships[8].author.id | https://openalex.org/A5079310882 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1504-3321 |
| authorships[8].author.display_name | Jacob Ellegood |
| authorships[8].countries | CA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2801317318 |
| authorships[8].affiliations[0].raw_affiliation_string | 5Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada |
| authorships[8].institutions[0].id | https://openalex.org/I2801317318 |
| authorships[8].institutions[0].ror | https://ror.org/057q4rt57 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2801317318 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | Hospital for Sick Children |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Jacob Ellegood |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | 5Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3H7, Canada |
| authorships[9].author.id | https://openalex.org/A5053795567 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-6986-5684 |
| authorships[9].author.display_name | Markus Wöhr |
| authorships[9].countries | BE, DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I161103922 |
| authorships[9].affiliations[0].raw_affiliation_string | 3Behavioral Neuroscience, Experimental and Biological Psychology, Faculty of Psychology, Philipps-University Marburg, Marburg, 35032, Germany |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I161103922 |
| authorships[9].affiliations[1].raw_affiliation_string | 4Center for Mind, Brain and Behavior, Philipps-University Marburg, Marburg, 35032, Germany |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I99464096 |
| authorships[9].affiliations[2].raw_affiliation_string | 9KU Leuven, Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, Leuven, B-3000, Belgium |
| authorships[9].affiliations[3].institution_ids | https://openalex.org/I4210153928 |
| authorships[9].affiliations[3].raw_affiliation_string | 10KU Leuven, Leuven Brain Institute, Leuven, B-3000, Belgium |
| authorships[9].institutions[0].id | https://openalex.org/I99464096 |
| authorships[9].institutions[0].ror | https://ror.org/05f950310 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I99464096 |
| authorships[9].institutions[0].country_code | BE |
| authorships[9].institutions[0].display_name | KU Leuven |
| authorships[9].institutions[1].id | https://openalex.org/I4210153928 |
| authorships[9].institutions[1].ror | https://ror.org/045c7t348 |
| authorships[9].institutions[1].type | facility |
| authorships[9].institutions[1].lineage | https://openalex.org/I2802017950, https://openalex.org/I4210153928, https://openalex.org/I99464096 |
| authorships[9].institutions[1].country_code | BE |
| authorships[9].institutions[1].display_name | VIB-KU Leuven Center for Brain & Disease Research |
| authorships[9].institutions[2].id | https://openalex.org/I161103922 |
| authorships[9].institutions[2].ror | https://ror.org/01rdrb571 |
| authorships[9].institutions[2].type | education |
| authorships[9].institutions[2].lineage | https://openalex.org/I161103922 |
| authorships[9].institutions[2].country_code | DE |
| authorships[9].institutions[2].display_name | Philipps University of Marburg |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Markus Wöhr |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | 10KU Leuven, Leuven Brain Institute, Leuven, B-3000, Belgium, 3Behavioral Neuroscience, Experimental and Biological Psychology, Faculty of Psychology, Philipps-University Marburg, Marburg, 35032, Germany, 4Center for Mind, Brain and Behavior, Philipps-University Marburg, Marburg, 35032, Germany, 9KU Leuven, Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, Leuven, B-3000, Belgium |
| authorships[10].author.id | https://openalex.org/A5050268402 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-9357-5476 |
| authorships[10].author.display_name | Jill L. Silverman |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[10].affiliations[0].raw_affiliation_string | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| authorships[10].institutions[0].id | https://openalex.org/I84218800 |
| authorships[10].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of California, Davis |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Jill L. Silverman |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | 1MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, California 95817 |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdf |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2021-09-13T00:00:00 |
| display_name | Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in theUbe3aDeletion Rat Model of Angelman Syndrome |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11928 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Genetic Syndromes and Imprinting |
| related_works | https://openalex.org/W3202970859, https://openalex.org/W2943613942, https://openalex.org/W4247981369, https://openalex.org/W2041807010, https://openalex.org/W4283164330, https://openalex.org/W4313442014, https://openalex.org/W3023975013, https://openalex.org/W1973485468, https://openalex.org/W2995442537, https://openalex.org/W1752412230 |
| cited_by_count | 22 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 9 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1523/jneurosci.0925-21.2021 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S5555990 |
| best_oa_location.source.issn | 0270-6474, 1529-2401 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0270-6474 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Neuroscience |
| best_oa_location.source.host_organization | https://openalex.org/P4310319739 |
| best_oa_location.source.host_organization_name | Society for Neuroscience |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319739 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | The Journal of Neuroscience |
| best_oa_location.landing_page_url | https://doi.org/10.1523/jneurosci.0925-21.2021 |
| primary_location.id | doi:10.1523/jneurosci.0925-21.2021 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S5555990 |
| primary_location.source.issn | 0270-6474, 1529-2401 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0270-6474 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Neuroscience |
| primary_location.source.host_organization | https://openalex.org/P4310319739 |
| primary_location.source.host_organization_name | Society for Neuroscience |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319739 |
| primary_location.license | |
| primary_location.pdf_url | https://www.jneurosci.org/content/jneuro/41/42/8801.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | The Journal of Neuroscience |
| primary_location.landing_page_url | https://doi.org/10.1523/jneurosci.0925-21.2021 |
| publication_date | 2021-09-02 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2803711209, https://openalex.org/W3152538668, https://openalex.org/W2045819396, https://openalex.org/W2412637008, https://openalex.org/W2136145485, https://openalex.org/W2231936665, https://openalex.org/W2789712560, https://openalex.org/W3111991061, https://openalex.org/W3049062340, https://openalex.org/W3001089571, https://openalex.org/W2157849519, https://openalex.org/W6675223316, https://openalex.org/W2149514160, https://openalex.org/W2082543557, https://openalex.org/W2140468855, https://openalex.org/W2078474819, https://openalex.org/W2037605578, https://openalex.org/W2803358151, https://openalex.org/W2166045656, https://openalex.org/W1707998845, https://openalex.org/W2146685566, https://openalex.org/W2077863458, https://openalex.org/W1857348637, https://openalex.org/W2999383439, https://openalex.org/W2016603062, https://openalex.org/W2031508158, https://openalex.org/W2053418371, https://openalex.org/W2098533627, https://openalex.org/W2611786193, https://openalex.org/W2513078709, https://openalex.org/W2566161814, https://openalex.org/W2059146082, https://openalex.org/W2141796362, https://openalex.org/W3118096229, https://openalex.org/W2737764543, https://openalex.org/W2065138462, https://openalex.org/W3001517812, https://openalex.org/W2131051578, https://openalex.org/W2985636215, https://openalex.org/W2164752954, https://openalex.org/W2529339498, https://openalex.org/W2883928542, https://openalex.org/W2734999854, https://openalex.org/W2054571451, https://openalex.org/W2428918274, https://openalex.org/W2163274894, https://openalex.org/W2799687693, https://openalex.org/W1999247495, https://openalex.org/W2584425130, https://openalex.org/W2037783396, https://openalex.org/W2586071800, https://openalex.org/W2318541730, https://openalex.org/W2045372468, https://openalex.org/W2550726007, https://openalex.org/W2618173862, https://openalex.org/W1983532821, https://openalex.org/W1988134422, https://openalex.org/W2726021207, https://openalex.org/W2308611819, https://openalex.org/W2017048113, https://openalex.org/W2224338964, https://openalex.org/W2801071623, https://openalex.org/W2907633248, https://openalex.org/W2898018470, https://openalex.org/W2990731195, https://openalex.org/W2777394414, https://openalex.org/W2138146369, https://openalex.org/W2004421347, https://openalex.org/W2015852090, https://openalex.org/W2415803807, https://openalex.org/W1980242006, https://openalex.org/W1985567838, https://openalex.org/W3100180752, https://openalex.org/W1988515618, https://openalex.org/W2803810267, https://openalex.org/W3131377125, https://openalex.org/W2049264784, https://openalex.org/W1546334636, https://openalex.org/W2023891230, https://openalex.org/W1986149871, https://openalex.org/W2073887073, https://openalex.org/W2090309375, https://openalex.org/W2604948112, https://openalex.org/W3094877238, https://openalex.org/W2899679902, https://openalex.org/W1991269326, https://openalex.org/W141215750, https://openalex.org/W2793074165, https://openalex.org/W3082003503, https://openalex.org/W2051384019, https://openalex.org/W2071528977, https://openalex.org/W1981366587, https://openalex.org/W2756096060, https://openalex.org/W1827567735, https://openalex.org/W2149631083, https://openalex.org/W2028338644, https://openalex.org/W1893871726, https://openalex.org/W2765939417, https://openalex.org/W2047216515, https://openalex.org/W2129034454, https://openalex.org/W3144952111, https://openalex.org/W2028293560, https://openalex.org/W1963502320, https://openalex.org/W2034728437, https://openalex.org/W2019149695, https://openalex.org/W2338078902, https://openalex.org/W3094331871, https://openalex.org/W3021526609, https://openalex.org/W2112927743, https://openalex.org/W2102019802, https://openalex.org/W1853997712, https://openalex.org/W3163773339, https://openalex.org/W4285719527 |
| referenced_works_count | 113 |
| abstract_inverted_index.a | 4, 20, 31, 60, 119, 170, 190, 212 |
| abstract_inverted_index.50 | 74 |
| abstract_inverted_index.AS | 45, 109, 196 |
| abstract_inverted_index.We | 27, 63, 206 |
| abstract_inverted_index.an | 88, 127, 260 |
| abstract_inverted_index.as | 154 |
| abstract_inverted_index.be | 151, 211, 275 |
| abstract_inverted_index.by | 10, 223, 245 |
| abstract_inverted_index.in | 35, 50, 78, 105, 134, 157, 263 |
| abstract_inverted_index.is | 3, 53, 59, 169, 177 |
| abstract_inverted_index.no | 178 |
| abstract_inverted_index.of | 44, 57, 84, 100, 160, 182, 195, 215, 266 |
| abstract_inverted_index.to | 29, 97, 197, 202, 210, 277 |
| abstract_inverted_index.AS, | 85, 216, 267 |
| abstract_inverted_index.AS. | 103, 163 |
| abstract_inverted_index.LTP | 129 |
| abstract_inverted_index.and | 14, 19, 37, 46, 65, 92, 131, 149, 235, 249, 268 |
| abstract_inverted_index.are | 243 |
| abstract_inverted_index.for | 68, 162, 174 |
| abstract_inverted_index.kHz | 75 |
| abstract_inverted_index.rat | 82, 193, 209, 257 |
| abstract_inverted_index.the | 69, 79, 98, 108, 158, 208, 239, 264, 269, 278 |
| abstract_inverted_index.(AS) | 2, 168 |
| abstract_inverted_index.Also | 104 |
| abstract_inverted_index.LTP, | 234 |
| abstract_inverted_index.This | 187, 256 |
| abstract_inverted_index.core | 61 |
| abstract_inverted_index.gait | 123 |
| abstract_inverted_index.lack | 56 |
| abstract_inverted_index.line | 106 |
| abstract_inverted_index.male | 36 |
| abstract_inverted_index.over | 220 |
| abstract_inverted_index.rare | 5 |
| abstract_inverted_index.rats | 39, 113 |
| abstract_inverted_index.that | 40 |
| abstract_inverted_index.used | 189 |
| abstract_inverted_index.will | 150, 274 |
| abstract_inverted_index.with | 24, 102, 107, 118, 144 |
| abstract_inverted_index.These | 137, 241 |
| abstract_inverted_index.Ube3a | 80, 111 |
| abstract_inverted_index.brain | 135 |
| abstract_inverted_index.cure, | 179 |
| abstract_inverted_index.field | 265 |
| abstract_inverted_index.first | 70 |
| abstract_inverted_index.found | 207 |
| abstract_inverted_index.model | 83, 194, 214, 258 |
| abstract_inverted_index.motor | 13, 247 |
| abstract_inverted_index.mouse | 147, 185, 221, 254 |
| abstract_inverted_index.novel | 120 |
| abstract_inverted_index.other | 47 |
| abstract_inverted_index.study | 188 |
| abstract_inverted_index.there | 176 |
| abstract_inverted_index.time, | 71 |
| abstract_inverted_index.using | 184 |
| abstract_inverted_index.which | 51, 86, 175 |
| abstract_inverted_index.across | 238 |
| abstract_inverted_index.and/or | 55 |
| abstract_inverted_index.brain. | 240 |
| abstract_inverted_index.female | 38 |
| abstract_inverted_index.happy, | 21 |
| abstract_inverted_index.herein | 66, 273 |
| abstract_inverted_index.highly | 152 |
| abstract_inverted_index.issues | 252 |
| abstract_inverted_index.models | 148, 222 |
| abstract_inverted_index.report | 67 |
| abstract_inverted_index.robust | 139 |
| abstract_inverted_index.severe | 171 |
| abstract_inverted_index.social | 116 |
| abstract_inverted_index.sought | 28 |
| abstract_inverted_index.speech | 58 |
| abstract_inverted_index.strong | 213 |
| abstract_inverted_index.affect, | 95 |
| abstract_inverted_index.balance | 15 |
| abstract_inverted_index.central | 276 |
| abstract_inverted_index.decades | 181 |
| abstract_inverted_index.despite | 180 |
| abstract_inverted_index.genetic | 6 |
| abstract_inverted_index.measure | 34 |
| abstract_inverted_index.metrics | 271 |
| abstract_inverted_index.models. | 186, 255 |
| abstract_inverted_index.outcome | 33, 155, 200, 270 |
| abstract_inverted_index.playful | 90 |
| abstract_inverted_index.provide | 141 |
| abstract_inverted_index.reduced | 232 |
| abstract_inverted_index.several | 218 |
| abstract_inverted_index.similar | 96 |
| abstract_inverted_index.strain, | 251 |
| abstract_inverted_index.unique, | 138 |
| abstract_inverted_index.volume. | 136 |
| abstract_inverted_index.Angelman | 0, 166 |
| abstract_inverted_index.aberrant | 115 |
| abstract_inverted_index.atypical | 54 |
| abstract_inverted_index.compared | 143 |
| abstract_inverted_index.deficit, | 130 |
| abstract_inverted_index.demeanor | 23, 91, 99 |
| abstract_inverted_index.disorder | 8, 173 |
| abstract_inverted_index.elevated | 93 |
| abstract_inverted_index.feature. | 62 |
| abstract_inverted_index.findings | 242 |
| abstract_inverted_index.frequent | 25 |
| abstract_inverted_index.impaired | 17, 125 |
| abstract_inverted_index.measures | 156, 201 |
| abstract_inverted_index.numerous | 225 |
| abstract_inverted_index.offering | 217 |
| abstract_inverted_index.partner, | 121 |
| abstract_inverted_index.plaguing | 253 |
| abstract_inverted_index.positive | 94 |
| abstract_inverted_index.profound | 132 |
| abstract_inverted_index.recently | 191 |
| abstract_inverted_index.reported | 272 |
| abstract_inverted_index.research | 183 |
| abstract_inverted_index.suggests | 87 |
| abstract_inverted_index.syndrome | 1, 167 |
| abstract_inverted_index.valuable | 153 |
| abstract_inverted_index.STATEMENT | 165 |
| abstract_inverted_index.abilities | 248 |
| abstract_inverted_index.addressed | 41 |
| abstract_inverted_index.anomalies | 237 |
| abstract_inverted_index.available | 146 |
| abstract_inverted_index.currently | 145 |
| abstract_inverted_index.deficits, | 16 |
| abstract_inverted_index.delineate | 198 |
| abstract_inverted_index.developed | 192 |
| abstract_inverted_index.disorders | 49 |
| abstract_inverted_index.elucidate | 30 |
| abstract_inverted_index.emissions | 77 |
| abstract_inverted_index.excessive | 72 |
| abstract_inverted_index.excitable | 22 |
| abstract_inverted_index.important | 261 |
| abstract_inverted_index.including | 228 |
| abstract_inverted_index.laughter. | 26 |
| abstract_inverted_index.pipeline. | 280 |
| abstract_inverted_index.therapies | 161 |
| abstract_inverted_index.advantages | 142, 219 |
| abstract_inverted_index.background | 250 |
| abstract_inverted_index.cognition, | 126 |
| abstract_inverted_index.evaluation | 159 |
| abstract_inverted_index.excitable, | 89 |
| abstract_inverted_index.exhibiting | 224 |
| abstract_inverted_index.facilitate | 203 |
| abstract_inverted_index.phenotype, | 110 |
| abstract_inverted_index.phenotypes | 140 |
| abstract_inverted_index.reductions | 133 |
| abstract_inverted_index.represents | 259 |
| abstract_inverted_index.ultrasonic | 76 |
| abstract_inverted_index.underlying | 128 |
| abstract_inverted_index.volumetric | 236 |
| abstract_inverted_index.AS-relevant | 226 |
| abstract_inverted_index.advancement | 262 |
| abstract_inverted_index.detrimental | 246 |
| abstract_inverted_index.discovered, | 64 |
| abstract_inverted_index.distinctive | 122 |
| abstract_inverted_index.hippocampal | 233 |
| abstract_inverted_index.individuals | 101 |
| abstract_inverted_index.mat–/pat+ | 81, 112 |
| abstract_inverted_index.phenotypes, | 227 |
| abstract_inverted_index.preclinical | 32 |
| abstract_inverted_index.therapeutic | 204, 279 |
| abstract_inverted_index.SIGNIFICANCE | 164 |
| abstract_inverted_index.demonstrated | 114 |
| abstract_inverted_index.development. | 205 |
| abstract_inverted_index.intellectual | 11 |
| abstract_inverted_index.interactions | 117 |
| abstract_inverted_index.neurogenetic | 172 |
| abstract_inverted_index.overabundant | 229 |
| abstract_inverted_index.unconfounded | 244 |
| abstract_inverted_index.abnormalities | 43 |
| abstract_inverted_index.characterized | 9 |
| abstract_inverted_index.communication | 42, 52 |
| abstract_inverted_index.disabilities, | 12 |
| abstract_inverted_index.laughter-like | 73, 230 |
| abstract_inverted_index.abnormalities, | 124 |
| abstract_inverted_index.communication, | 18 |
| abstract_inverted_index.vocalizations, | 231 |
| abstract_inverted_index.disease-relevant | 199 |
| abstract_inverted_index.neurodevelopmental | 7, 48 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.88421825 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |