Exercise capacity in patients with repaired Tetralogy of Fallot aged 6 to 63 years Article Swipe
Graziëlla Eshuis
,
Julia Hock
,
Gideon Marchie du Sarvaas
,
H. van Duinen
,
Rhoia Neidenbach
,
Freek van den Heuvel
,
Hans Hillege
,
Rolf M.F. Berger
,
Alfred Hager
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/heartjnl-2020-318928
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/heartjnl-2020-318928
Objectives This study aimed to provide a perspective for the interpretation of exercise capacity (peakVO 2 ) in patients with repaired Tetralogy of Fallot (patients with rTOF) by describing the course of peakVO 2 from patients aged 6–63 years. Methods A retrospective study was performed between September 2001 and December 2016 in the German Heart Centre Munich, Germany, and in the University Medical Centre Groningen, the Netherlands. A total of 1175 cardiopulmonary exercise tests (CPETs) were collected from 586 patients with rTOF, 46% female. Maximal exertion was verified using a respiratory exchange ratio ≥1.00. PeakVO 2 was modelled using time-dependent multilevel models for repeated measurements (n=889 in 300 patients), and compared with subject-specific reference values calculated by the models of Bongers et al and Mylius et al. Results The peakVO 2 of patients with rTOF was reduced at all ages. At the age of 6, the peakVO 2 was 614 mL/min (70% of predicted (95% CI 67 to 73)). The reduced increase in peakVO 2 during adolescence resulted in a significant lower maximum peakVO 2 of 1209 mL/min at 25 years (65% predicted, p<0.001). A linear decline after 25 years was observed in patients and references, although patients showed an accelerated decline, with a -0.24% point of predicted (95% CI 0.11 to 0.38) per year without differences between sexes (p=0.263). Conclusions This study provides a context for peakVO 2 across ages in patients with rTOF under contemporary treatment strategies. It showed that the reduction in peakVO 2 originates from childhood and declines over time. Sex differences in patients with rTOF were similar to natural existing sex differences.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/heartjnl-2020-318928
- OA Status
- green
- Cited By
- 22
- References
- 33
- Related Works
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- OpenAlex ID
- https://openalex.org/W3159983234
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3159983234Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/heartjnl-2020-318928Digital Object Identifier
- Title
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Exercise capacity in patients with repaired Tetralogy of Fallot aged 6 to 63 yearsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-05-14Full publication date if available
- Authors
-
Graziëlla Eshuis, Julia Hock, Gideon Marchie du Sarvaas, H. van Duinen, Rhoia Neidenbach, Freek van den Heuvel, Hans Hillege, Rolf M.F. Berger, Alfred HagerList of authors in order
- Landing page
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https://doi.org/10.1136/heartjnl-2020-318928Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://research.rug.nl/en/publications/95ab62f5-5b8e-4142-801e-bd5520e317b9Direct OA link when available
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Medicine, Tetralogy of Fallot, Context (archaeology), Exertion, Internal medicine, Cardiology, Retrospective cohort study, Surgery, Heart disease, Paleontology, BiologyTop concepts (fields/topics) attached by OpenAlex
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22Total citation count in OpenAlex
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2025: 5, 2024: 8, 2023: 5, 2022: 3Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.references, | 195 |
| abstract_inverted_index.respiratory | 90 |
| abstract_inverted_index.significant | 170 |
| abstract_inverted_index.strategies. | 238 |
| abstract_inverted_index.Netherlands. | 66 |
| abstract_inverted_index.contemporary | 236 |
| abstract_inverted_index.differences. | 266 |
| abstract_inverted_index.measurements | 104 |
| abstract_inverted_index.p<0.001). | 183 |
| abstract_inverted_index.retrospective | 41 |
| abstract_inverted_index.interpretation | 10 |
| abstract_inverted_index.time-dependent | 99 |
| abstract_inverted_index.cardiopulmonary | 71 |
| abstract_inverted_index.subject-specific | 112 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89504451 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |