Exercise modality‐dependent mitochondrial respiratory capacity in satellite cells and conditioned serum‐induced responses in cultured myotubes Article Swipe
Takanaga Shirai
,
Hiroshi Shinkai
,
Riku Tanimura
,
Kazuki Uemichi
,
Shunsuke Sugiyama
,
Kohei Takeda
,
Yu Kitaoka
,
Tohru Takemasa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1113/ep092922
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1113/ep092922
Exercise‐induced mitochondrial adaptations contribute to muscle function and metabolic health. We aimed to investigate the association of moderate‐intensity swimming (MOD) and high‐intensity interval training (HIIT) with mitochondrial function in skeletal muscle cells treated with exercise‐conditioned serum. Male ICR mice (7–8 weeks old) were assigned to the Sedentary, MOD or HIIT group. The MOD group underwent five sessions of 60 min. The HIIT group performed weighted high‐intensity swimming intervals. This study assessed mitochondrial enzyme activity in the plantaris muscle, mitochondrial respiratory capacity in isolated satellite cells, and mitochondrial function in C2C12 myotubes treated with exercise‐derived serum. Serum was obtained immediately and 24 h postexercise to assess acute effects and chronic adaptations, respectively. The MOD and HIIT groups demonstrated significantly increased muscle citrate synthase and cytochrome c oxidase activities compared with the Sedentary group, but with no significant differences between the MOD and HIIT groups. Satellite cells exhibited higher basal respiration, ATP production and maximal respiratory capacity in the MOD group than in the Sedentary and HIIT groups. Acute serum notably improved maximal mitochondrial respiration in cultured C2C12 myotubes in the HIIT group, whereas serum from chronic training improved those parameters but demonstrated no modality‐specific effects. MOD enhances mitochondrial respiratory function in satellite cells, probably owing to sustained aerobic metabolic signalling, whereas HIIT produces a potent but transient systemic response that acutely boosts mitochondrial function in muscle cells. The differential effects of exercise modalities emphasize the importance of timing and exercise modality in driving specific mitochondrial adaptations, thereby providing valuable insights for tailored exercise prescriptions for optimizing metabolic health.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1113/ep092922
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/EP092922
- OA Status
- diamond
- Cited By
- 1
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411283210
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411283210Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1113/ep092922Digital Object Identifier
- Title
-
Exercise modality‐dependent mitochondrial respiratory capacity in satellite cells and conditioned serum‐induced responses in cultured myotubesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-06-13Full publication date if available
- Authors
-
Takanaga Shirai, Hiroshi Shinkai, Riku Tanimura, Kazuki Uemichi, Shunsuke Sugiyama, Kohei Takeda, Yu Kitaoka, Tohru TakemasaList of authors in order
- Landing page
-
https://doi.org/10.1113/ep092922Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/EP092922Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/EP092922Direct OA link when available
- Concepts
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Myogenesis, Modality (human–computer interaction), Satellite, Respiratory system, Mitochondrion, Endocrinology, Internal medicine, Medicine, Biology, Cell biology, Physics, Myocyte, Computer science, Human–computer interaction, AstronomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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68Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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