Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 years Article Swipe
Yousuke Sugita
,
Katsuhiko Ito
,
Yui Yoshioka
,
Ayano Kudo
,
Sota Arakawa
,
Satoshi Sakai
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2023.1246739
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2023.1246739
Introduction Exercise training is an established intervention method for improving exercise capacity and survival rates in patients with heart failure with preserved ejection fraction (HFpEF). However, most reports have focused on European and American patients, with limited data regarding the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in East Asian patients. This study investigated the effects of exercise training on cardiac function, hemodynamics, and exercise capacity in Japanese patients aged 65–80 years with HFpEF. Methods This single-center, open-label, non-randomized, controlled trial prospectively enrolled 99 outpatients. Eligibility criteria for HFpEF patients were an HFA score ≥5 in addition to clinical symptoms of heart failure and left ventricular diastolic dysfunction. Exercise training in the intervention group consisted of aerobic exercise and strength training thrice weekly for 5 months. Patients in the control group continued the usual treatment for 5 months. Resting cardiac function was evaluated using echocardiography. Peak oxygen uptake (peakVO 2 ), ventilatory equivalent (VE) vs. carbon dioxide output (VCO 2 ) slope, peak cardiac output index, and arteriovenous oxygen difference were calculated using cardiopulmonary exercise testing combined with impedance cardiography. Results After 5 months of exercise training, remarkable interactions were observed, with peakVO 2 as the primary outcome. Additionally, significant interactions were observed between hemodynamic indices and some echocardiographic parameters. The mean percentage change in peakVO 2 from baseline was 8.3% in the intervention group. Fifteen study participants (30.1%) in the intervention group achieved a clinically meaningful change of 3.0 ml/min/kg (10% improvement) in peakVO 2 from baseline. The group with 3.0 ml/min/kg or 10% improvement in peakVO 2 from baseline had a considerably lower prevalence of diabetes mellitus and VE vs. VCO 2 slope and considerably higher left atrial-global longitudinal strain values than the group without any notable improvements. Conclusions Although exercise training can help improve exercise intolerance in Japanese patients aged 65–80 years with HFpEF, its benefits are limited. Our results suggest that HFpEF, complicated by diabetes mellitus and decreased ventilatory efficiency during exercise, may require reconsideration of intervention strategies. This trial was registered with the University Hospital Medical Information Network, a trial registry in Japan (registration number: UMIN000045474).
Related Topics
Concepts
Medicine
Ejection fraction
Heart failure
Cardiology
VO2 max
Internal medicine
Hemodynamics
Heart failure with preserved ejection fraction
Impedance cardiography
Aerobic exercise
Randomized controlled trial
Cardiac output
Cardiac function curve
Cardiac index
Stroke volume
Physical therapy
Heart rate
Blood pressure
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2023.1246739
- https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246739/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 2
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388021692
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388021692Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fcvm.2023.1246739Digital Object Identifier
- Title
-
Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 yearsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-30Full publication date if available
- Authors
-
Yousuke Sugita, Katsuhiko Ito, Yui Yoshioka, Ayano Kudo, Sota Arakawa, Satoshi SakaiList of authors in order
- Landing page
-
https://doi.org/10.3389/fcvm.2023.1246739Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246739/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1246739/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Medicine, Ejection fraction, Heart failure, Cardiology, VO2 max, Internal medicine, Hemodynamics, Heart failure with preserved ejection fraction, Impedance cardiography, Aerobic exercise, Randomized controlled trial, Cardiac output, Cardiac function curve, Cardiac index, Stroke volume, Physical therapy, Heart rate, Blood pressureTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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