Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis Article Swipe

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Rebecca K. Donegan , Yibo Fu , Jacqueline Copeland , Stanzin Idga , Gabriel Brown , Owen F. Hale , Avishek Mitra , Hui Yang , Harry A. Dailey , Michael Niederweis , Paras Jain , Amit R. Reddi ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1128/spectrum.03604-22

Mycobacterium tuberculosis infects ~25% of the world’s population and causes tuberculosis (TB), the second leading cause of death from infectious disease. Heme is an essential metabolite for M. tuberculosis , and targeting the unique heme biosynthetic pathway of M. tuberculosis could serve as an effective therapeutic strategy.

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Mycobacterium Tuberculosis

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Mycobacterium tuberculosis Heme Biology Tuberculosis Chemistry Biochemistry Medicine Enzyme Pathology

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Type: article
Language: en
Landing Page: https://doi.org/10.1128/spectrum.03604-22
OA Status: gold
Cited By: 15
References: 70
Related Works: 10
OpenAlex ID: https://openalex.org/W4297459351

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DOI: https://doi.org/10.1128/spectrum.03604-22

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Title: Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

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Type: article

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Language: en

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Publication year: 2022

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Publication date: 2022-09-28

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Authors: Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi

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Landing page: https://doi.org/10.1128/spectrum.03604-22

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Open access: Yes

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OA status: gold

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OA URL: https://doi.org/10.1128/spectrum.03604-22

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Concepts: Mycobacterium tuberculosis, Heme, Biology, Tuberculosis, Chemistry, Biochemistry, Medicine, Enzyme, Pathology

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Cited by: 15

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Citations by year (recent): 2025: 7, 2024: 5, 2023: 3

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