Exome Sequencing in a Family Identifies RECQL5 Mutation Resulting in Early Myocardial Infarction Article Swipe
Xiang Xie
,
Ying‐Ying Zheng
,
Dilare Adi
,
Yi‐Ning Yang
,
Yi-Tong Ma
,
Xiaomei Li
,
Zhen-Yan Fu
,
Xiang Ma
,
Fen Liu
,
Zi-Xiang Yu
,
You Chen
,
Ying Huang
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1097/md.0000000000002737
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1097/md.0000000000002737
Coronary artery disease (CAD) including myocardial infarction (MI) is the leading cause of death worldwide and is commonly caused by the interaction between genetic factors and environmental risks. Despite intensive efforts using linkage and candidate gene approaches, the genetic etiology for the majority of families with a multigenerational early CAD /MI predisposition is unknown.In this study, we used whole-exome sequencing of 10 individuals from 1 early MI family, in which 4 siblings were diagnosed with MI before the age of 55, to identify potential predisposing genes.We identified a mutation in the RECQL5 gene, 1 of the 5 members of the RECQ family which are involved in the maintenance of genomic stability. This novel mutation, which is a TG insert at position 73,626,918 on the 13 chromosome and occurs before the last nucleotide of the introns 11 acceptor splice site affecting splicing of RECQL5. RT-PCR suggested the control subject had a full-length mRNA including exon 12, but the patients with RECQL5 mutation had a shorter mRNA form involving splicing of exons 11 to 13 directly, with skipping of exon 12. Quantitative RT-PCR analysis of RECQL5 exon 12 demonstrated that individuals whose genotype is mutant homozygote had only trace amounts of mRNA containing this exon and the family members who carry the heterozygous genotype had a level at 48% to 55% of the control's level.These findings provide insight into both the pathogenesis of MI and the role of RECQL5 gene in human disease.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/md.0000000000002737
- OA Status
- gold
- Cited By
- 12
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1982537755
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- OpenAlex ID
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https://openalex.org/W1982537755Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/md.0000000000002737Digital Object Identifier
- Title
-
Exome Sequencing in a Family Identifies RECQL5 Mutation Resulting in Early Myocardial InfarctionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-02-01Full publication date if available
- Authors
-
Xiang Xie, Ying‐Ying Zheng, Dilare Adi, Yi‐Ning Yang, Yi-Tong Ma, Xiaomei Li, Zhen-Yan Fu, Xiang Ma, Fen Liu, Zi-Xiang Yu, You Chen, Ying HuangList of authors in order
- Landing page
-
https://doi.org/10.1097/md.0000000000002737Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1097/md.0000000000002737Direct OA link when available
- Concepts
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Exon, Genetics, Medicine, Exome sequencing, Mutation, Splice site mutation, Genetic testing, Intron, Gene, Biology, Alternative splicingTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2, 2023: 5, 2022: 2, 2021: 1, 2020: 1Per-year citation counts (last 5 years)
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20Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| authorships[0].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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| authorships[0].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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| authorships[1].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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| authorships[1].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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| authorships[2].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[2].institutions[0].id | https://openalex.org/I102398690 |
| authorships[2].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Dilare Adi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[3].author.id | https://openalex.org/A5079087568 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8332-8508 |
| authorships[3].author.display_name | Yi‐Ning Yang |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[3].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[3].institutions[0].id | https://openalex.org/I102398690 |
| authorships[3].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yi-Ning Yang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[4].author.id | https://openalex.org/A5100720803 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Yi-Tong Ma |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[4].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[4].institutions[0].id | https://openalex.org/I102398690 |
| authorships[4].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yi-Tong Ma |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[5].author.id | https://openalex.org/A5100413473 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8870-3186 |
| authorships[5].author.display_name | Xiaomei Li |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[5].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[5].institutions[0].id | https://openalex.org/I102398690 |
| authorships[5].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Xiao-Mei Li |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[6].author.id | https://openalex.org/A5047585547 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2194-1275 |
| authorships[6].author.display_name | Zhen-Yan Fu |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[6].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[6].institutions[0].id | https://openalex.org/I102398690 |
| authorships[6].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Zhen-Yan Fu |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[7].author.id | https://openalex.org/A5113786765 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Xiang Ma |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[7].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[7].institutions[0].id | https://openalex.org/I102398690 |
| authorships[7].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Xiang Ma |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[8].author.id | https://openalex.org/A5100724433 |
| authorships[8].author.orcid | https://orcid.org/0009-0003-5325-1604 |
| authorships[8].author.display_name | Fen Liu |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[8].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[8].institutions[0].id | https://openalex.org/I102398690 |
| authorships[8].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[8].institutions[0].type | government |
| authorships[8].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Fen Liu |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[9].author.id | https://openalex.org/A5101003151 |
| authorships[9].author.orcid | https://orcid.org/0009-0003-4909-858X |
| authorships[9].author.display_name | Zi-Xiang Yu |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[9].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[9].institutions[0].id | https://openalex.org/I102398690 |
| authorships[9].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Zi-Xiang Yu |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[10].author.id | https://openalex.org/A5100714055 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-4916-0334 |
| authorships[10].author.display_name | You Chen |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[10].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[10].institutions[0].id | https://openalex.org/I102398690 |
| authorships[10].institutions[0].ror | https://ror.org/01h0zpd94 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I102398690 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | National Natural Science Foundation of China |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | You Chen |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
| authorships[11].author.id | https://openalex.org/A5005827885 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0543-0256 |
| authorships[11].author.display_name | Ying Huang |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I102398690 |
| authorships[11].affiliations[0].raw_affiliation_string | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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| authorships[11].raw_author_name | Ying Huang |
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| authorships[11].raw_affiliation_strings | Abbreviations: AMI = acute myocardial infarction, BMI = body mass index, BWA = Burrows–Wheeler alignment, CAD = coronary artery disease, GATK = Genome Analysis Toolkit, GWAS = genome-wide association studies, MI = myocardial infarction.; Accepted January 15, 2016; Disclosure: None.; From the Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.; Funding: this work has been supported financially by grants from the National Natural Science Foundation of China (81470014).; Received May 21, 2015; Received in revised form January 12, 2016; The authors have no conflicts of interest to disclose.; This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0; XX and Y-YZ equally contributed to this study.; Yi-Ning Yang, No. 137, Liyushan Road, Urumqi, China (e-mail: [email protected]). |
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