Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers Article Swipe
Ella F Gunady
,
Kathryn E. Ware
,
Sarah Hoskinson Plumlee
,
Nicolas Devos
,
David L. Corcoran
,
Joseph A. Prinz
,
Hrvoje Mišetić
,
Francesca D. Ciccarelli
,
Tara M. Harrison
,
Jeffrey L. Thorne
,
Robert Schopler
,
Jeffrey I. Everitt
,
William C. Eward
,
Jason A. Somarelli
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/emph/eoac016
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/emph/eoac016
Background and objectives Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma in prosimians may point to possible causes, treatments and methods of prevention, aiding conservation efforts that are particularly crucial to the survival of endangered lemurs. Although genomic studies of cancer in non-human primates have been hampered by a lack of tools, recent studies have demonstrated the efficacy of using human exome capture reagents across primates. Methodology In this proof-of-principle study, we applied human exome capture reagents to tumor–normal pairs from five lemurs with hepatocellular carcinoma to characterize the mutational landscape of this disease in lemurs. Results Several genes implicated in human hepatocellular carcinoma, including ARID1A, TP53 and CTNNB1, were mutated in multiple lemurs, and analysis of cancer driver genes mutated in these samples identified enrichment of genes involved with TP53 degradation and regulation. In addition to these similarities with human hepatocellular carcinoma, we also noted unique features, including six genes that contain mutations in all five lemurs. Interestingly, these genes are infrequently mutated in human hepatocellular carcinoma, suggesting potential differences in the etiology and/or progression of this cancer in lemurs and humans. Conclusions and implications Collectively, this pilot study suggests that human exome capture reagents are a promising tool for genomic studies of cancer in lemurs and other non-human primates. Lay Summary Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers is unknown. In this proof-of-principle study, we applied human DNA sequencing tools to tumor–normal pairs from five lemurs with hepatocellular carcinoma and compared the lemur mutation profiles to those of human hepatocellular carcinomas.
Related Topics
Concepts
Exome sequencing
Lemur
Hepatocellular carcinoma
Medicine
Cancer
Exome
Bioinformatics
Biology
Genetics
Internal medicine
Mutation
Gene
Ecology
Primate
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/emph/eoac016
- https://academic.oup.com/emph/article-pdf/10/1/221/43625179/eoac016.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226185318
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4226185318Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/emph/eoac016Digital Object Identifier
- Title
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Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer driversWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
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Ella F Gunady, Kathryn E. Ware, Sarah Hoskinson Plumlee, Nicolas Devos, David L. Corcoran, Joseph A. Prinz, Hrvoje Mišetić, Francesca D. Ciccarelli, Tara M. Harrison, Jeffrey L. Thorne, Robert Schopler, Jeffrey I. Everitt, William C. Eward, Jason A. SomarelliList of authors in order
- Landing page
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https://doi.org/10.1093/emph/eoac016Publisher landing page
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https://academic.oup.com/emph/article-pdf/10/1/221/43625179/eoac016.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/emph/article-pdf/10/1/221/43625179/eoac016.pdfDirect OA link when available
- Concepts
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Exome sequencing, Lemur, Hepatocellular carcinoma, Medicine, Cancer, Exome, Bioinformatics, Biology, Genetics, Internal medicine, Mutation, Gene, Ecology, PrimateTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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