Exosome Processing and Characterization Approaches for Research and Technology Development Article Swipe
James J. Lai
,
Zoe L. Chau
,
Sheng‐You Chen
,
John J. Hill
,
Katalin V. Korpany
,
Nai‐Wen Liang
,
Li‐Han Lin
,
Yi‐Hsuan Lin
,
Joanne K. Liu
,
Yu‐Chung Liu
,
Ruby Lunde
,
Wei‐Ting Shen
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202103222
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202103222
Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well‐characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on‐going clinical trials.
Related Topics
Concepts
Exosome
Microvesicles
Extracellular vesicles
Computational biology
Workflow
Extracellular vesicle
Nanotechnology
Computer science
Biology
microRNA
Cell biology
Materials science
Biochemistry
Database
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202103222
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202103222
- OA Status
- gold
- Cited By
- 479
- References
- 364
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220703150
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220703150Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/advs.202103222Digital Object Identifier
- Title
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Exosome Processing and Characterization Approaches for Research and Technology DevelopmentWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-25Full publication date if available
- Authors
-
James J. Lai, Zoe L. Chau, Sheng‐You Chen, John J. Hill, Katalin V. Korpany, Nai‐Wen Liang, Li‐Han Lin, Yi‐Hsuan Lin, Joanne K. Liu, Yu‐Chung Liu, Ruby Lunde, Wei‐Ting ShenList of authors in order
- Landing page
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https://doi.org/10.1002/advs.202103222Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202103222Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202103222Direct OA link when available
- Concepts
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Exosome, Microvesicles, Extracellular vesicles, Computational biology, Workflow, Extracellular vesicle, Nanotechnology, Computer science, Biology, microRNA, Cell biology, Materials science, Biochemistry, Database, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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479Total citation count in OpenAlex
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2025: 224, 2024: 160, 2023: 75, 2022: 20Per-year citation counts (last 5 years)
- References (count)
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364Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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