Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair Article Swipe
Ning Zhang
,
Jinyun Zhu
,
Qunchao Ma
,
Yun Zhao
,
Yingchao Wang
,
Xinyang Hu
,
Jinghai Chen
,
Wei Zhu
,
ZhongChao Han
,
Hong Yu
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.23883/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.2.23883/v1
Backhround: Age and other cardiovascular risk factors have been reported to impair the activities of mesenchymal stem cells (MSCs), which will affect the efficacy of stem cell transplantation. The objective of the study is to investigate whether exosomes derived from human umbilical cord MSCs (UMSCs) could enhance the activities of bone marrow MSCs from old person (OMSCs), and improve their capacity for cardiac repair. Methods: Exosomes extracted from conditioned medium of UMSCs were used to treat OMSCs to generate OMSCs Exo . The key molecule in the exosomes that have potential to rejuvenate aged MSCs were screened, and the role of OMSC was tested in the mouse model of mycardiac infarction(MI). Results: We found the activity of senescence-associated β-galactosidase and the expression of aging-related factors such as p53, p21, and p16 were significantly higher in OMSCs than those in UMSCs. After treatment with UMSC exosomes, these senescence phenotypes of OMSCs were remarkably reduced. The proliferation, migration, differentiation, anti-apoptotic and paracrine effect were increased in OMSCs Exo . In vivo study, mice with cardiac infarction had significantly better cardiac function, less fibrosis, and more angiogenesis after they were injected with OMSCs Exo as compared with those with OMSC. There was more miR-136 expression in UMSCs and OMSCs Exo than in OMSCs. Upregulation of miR-136 by transfection of miR-136 mimic into OMSCs significantly attenuated the apoptosis and senescence of OMSCs. Apoptotic peptidase activating factor (Apaf1) was found to be the downstream gene that is negatively regulated by miR-136 via directly targeting at its 3’UTR. Conclusion: Our data suggest that exosomes from young MSCs can improve activities of aged MSCs and enhance their function for myocardial repair by transferring exosomal miR-136 and downregulating Apaf1.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.2.23883/v1
- https://www.researchsquare.com/article/rs-14444/v1.pdf
- OA Status
- green
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4246357810
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4246357810Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.2.23883/v1Digital Object Identifier
- Title
-
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repairWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-18Full publication date if available
- Authors
-
Ning Zhang, Jinyun Zhu, Qunchao Ma, Yun Zhao, Yingchao Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, ZhongChao Han, Hong YuList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.2.23883/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-14444/v1.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-14444/v1.pdfDirect OA link when available
- Concepts
-
Microvesicles, Umbilical cord, Mesenchymal stem cell, Medicine, Cell biology, Biology, Bioinformatics, Immunology, microRNA, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4246357810 |
|---|---|
| doi | https://doi.org/10.21203/rs.2.23883/v1 |
| ids.doi | https://doi.org/10.21203/rs.2.23883/v1 |
| ids.openalex | https://openalex.org/W4246357810 |
| fwci | |
| type | preprint |
| title | Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10773 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9991999864578247 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Extracellular vesicles in disease |
| topics[1].id | https://openalex.org/T12264 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9860000014305115 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Tissue Engineering and Regenerative Medicine |
| topics[2].id | https://openalex.org/T11277 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.9807000160217285 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2505 |
| topics[2].subfield.display_name | Materials Chemistry |
| topics[2].display_name | Thermal properties of materials |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C20518536 |
| concepts[0].level | 4 |
| concepts[0].score | 0.9064486622810364 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q6840469 |
| concepts[0].display_name | Microvesicles |
| concepts[1].id | https://openalex.org/C2776955114 |
| concepts[1].level | 2 |
| concepts[1].score | 0.8627697825431824 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q172563 |
| concepts[1].display_name | Umbilical cord |
| concepts[2].id | https://openalex.org/C198826908 |
| concepts[2].level | 2 |
| concepts[2].score | 0.8368958234786987 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1922379 |
| concepts[2].display_name | Mesenchymal stem cell |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4628784656524658 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C95444343 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3872010111808777 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[4].display_name | Cell biology |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.3463869094848633 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C60644358 |
| concepts[6].level | 1 |
| concepts[6].score | 0.33966994285583496 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[6].display_name | Bioinformatics |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.30626600980758667 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C145059251 |
| concepts[8].level | 3 |
| concepts[8].score | 0.2024257779121399 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q310899 |
| concepts[8].display_name | microRNA |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.08149203658103943 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/microvesicles |
| keywords[0].score | 0.9064486622810364 |
| keywords[0].display_name | Microvesicles |
| keywords[1].id | https://openalex.org/keywords/umbilical-cord |
| keywords[1].score | 0.8627697825431824 |
| keywords[1].display_name | Umbilical cord |
| keywords[2].id | https://openalex.org/keywords/mesenchymal-stem-cell |
| keywords[2].score | 0.8368958234786987 |
| keywords[2].display_name | Mesenchymal stem cell |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.4628784656524658 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/cell-biology |
| keywords[4].score | 0.3872010111808777 |
| keywords[4].display_name | Cell biology |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.3463869094848633 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/bioinformatics |
| keywords[6].score | 0.33966994285583496 |
| keywords[6].display_name | Bioinformatics |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.30626600980758667 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/microrna |
| keywords[8].score | 0.2024257779121399 |
| keywords[8].display_name | microRNA |
| keywords[9].id | https://openalex.org/keywords/genetics |
| keywords[9].score | 0.08149203658103943 |
| keywords[9].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.21203/rs.2.23883/v1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402450 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Research Square (Research Square) |
| locations[0].source.host_organization | https://openalex.org/I4210096694 |
| locations[0].source.host_organization_name | Research Square (United States) |
| locations[0].source.host_organization_lineage | https://openalex.org/I4210096694 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-14444/v1.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.2.23883/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5100404874 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6430-4236 |
| authorships[0].author.display_name | Ning Zhang |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[0].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[0].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[0].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ning Zhang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[1].author.id | https://openalex.org/A5102481302 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Jinyun Zhu |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[1].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[1].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[1].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | JinYun Zhu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[2].author.id | https://openalex.org/A5057592558 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Qunchao Ma |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[2].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[2].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[2].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | QunChao Ma |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[3].author.id | https://openalex.org/A5056950769 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6357-9422 |
| authorships[3].author.display_name | Yun Zhao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[3].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[3].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[3].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yun Zhao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[4].author.id | https://openalex.org/A5101867157 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3590-9233 |
| authorships[4].author.display_name | Yingchao Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I76130692 |
| authorships[4].affiliations[0].raw_affiliation_string | Zhejiang University |
| authorships[4].institutions[0].id | https://openalex.org/I76130692 |
| authorships[4].institutions[0].ror | https://ror.org/00a2xv884 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I76130692 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Zhejiang University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | YingChao Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Zhejiang University |
| authorships[5].author.id | https://openalex.org/A5019986276 |
| authorships[5].author.orcid | https://orcid.org/0009-0009-4490-6043 |
| authorships[5].author.display_name | Xinyang Hu |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[5].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[5].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[5].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | XinYang Hu |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[6].author.id | https://openalex.org/A5045814682 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-5401-047X |
| authorships[6].author.display_name | Jinghai Chen |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[6].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[6].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[6].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | JingHai Chen |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[7].author.id | https://openalex.org/A5102751085 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2085-4092 |
| authorships[7].author.display_name | Wei Zhu |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210158318 |
| authorships[7].affiliations[0].raw_affiliation_string | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[7].institutions[0].id | https://openalex.org/I4210158318 |
| authorships[7].institutions[0].ror | https://ror.org/059cjpv64 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210158318 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Second Affiliated Hospital of Zhejiang University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Wei Zhu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Zhejiang University School of Medicine Second Affiliated Hospital |
| authorships[8].author.id | https://openalex.org/A5008374233 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | ZhongChao Han |
| authorships[8].affiliations[0].raw_affiliation_string | State Key Laboratory Of Experimental Hematology |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | ZhongChao Han |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | State Key Laboratory Of Experimental Hematology |
| authorships[9].author.id | https://openalex.org/A5075662890 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0521-8933 |
| authorships[9].author.display_name | Hong Yu |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Hong Yu |
| authorships[9].is_corresponding | False |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-14444/v1.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10773 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9991999864578247 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Extracellular vesicles in disease |
| related_works | https://openalex.org/W4238390078, https://openalex.org/W2903989816, https://openalex.org/W1985945858, https://openalex.org/W4253711409, https://openalex.org/W2150281802, https://openalex.org/W2470671226, https://openalex.org/W3214468175, https://openalex.org/W1785326690, https://openalex.org/W4400748341, https://openalex.org/W2799494827 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.2.23883/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402450 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Research Square (Research Square) |
| best_oa_location.source.host_organization | https://openalex.org/I4210096694 |
| best_oa_location.source.host_organization_name | Research Square (United States) |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-14444/v1.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.2.23883/v1 |
| primary_location.id | doi:10.21203/rs.2.23883/v1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402450 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Research Square (Research Square) |
| primary_location.source.host_organization | https://openalex.org/I4210096694 |
| primary_location.source.host_organization_name | Research Square (United States) |
| primary_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-14444/v1.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.2.23883/v1 |
| publication_date | 2020-02-18 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2039700634, https://openalex.org/W1983344320, https://openalex.org/W4244734753, https://openalex.org/W2736437772, https://openalex.org/W2106504494, https://openalex.org/W2886514991, https://openalex.org/W2574261953, https://openalex.org/W2585783657, https://openalex.org/W4213385752, https://openalex.org/W1909192843, https://openalex.org/W4248820821, https://openalex.org/W2151948534, https://openalex.org/W2224328263, https://openalex.org/W2774920603, https://openalex.org/W2756231443, https://openalex.org/W2925372744, https://openalex.org/W2020833650, https://openalex.org/W2143836800, https://openalex.org/W2778694820, https://openalex.org/W2935837027, https://openalex.org/W2259600410, https://openalex.org/W1497251274, https://openalex.org/W2763782267, https://openalex.org/W2073567151, https://openalex.org/W2589092927, https://openalex.org/W1980295643, https://openalex.org/W2052344110, https://openalex.org/W2497469513, https://openalex.org/W2177351862, https://openalex.org/W2508206631, https://openalex.org/W2942100880, https://openalex.org/W2150940840, https://openalex.org/W2037361029, https://openalex.org/W1982294959, https://openalex.org/W2592069257, https://openalex.org/W2587756991, https://openalex.org/W2794480120, https://openalex.org/W1966780233 |
| referenced_works_count | 38 |
| abstract_inverted_index.. | 82, 167 |
| abstract_inverted_index.In | 168 |
| abstract_inverted_index.We | 113 |
| abstract_inverted_index.as | 127, 192 |
| abstract_inverted_index.at | 250 |
| abstract_inverted_index.be | 237 |
| abstract_inverted_index.by | 214, 245, 275 |
| abstract_inverted_index.in | 86, 105, 135, 139, 164, 203, 209 |
| abstract_inverted_index.is | 34, 242 |
| abstract_inverted_index.of | 15, 25, 31, 50, 71, 101, 109, 117, 123, 149, 212, 216, 227, 265 |
| abstract_inverted_index.to | 11, 35, 75, 78, 92, 236 |
| abstract_inverted_index.Age | 2 |
| abstract_inverted_index.Exo | 81, 166, 191, 207 |
| abstract_inverted_index.Our | 254 |
| abstract_inverted_index.The | 29, 83, 154 |
| abstract_inverted_index.and | 3, 58, 98, 120, 130, 159, 182, 205, 225, 268, 279 |
| abstract_inverted_index.can | 262 |
| abstract_inverted_index.for | 62, 272 |
| abstract_inverted_index.had | 175 |
| abstract_inverted_index.its | 251 |
| abstract_inverted_index.key | 84 |
| abstract_inverted_index.old | 55 |
| abstract_inverted_index.p16 | 131 |
| abstract_inverted_index.the | 13, 23, 32, 48, 87, 99, 106, 115, 121, 223, 238 |
| abstract_inverted_index.via | 247 |
| abstract_inverted_index.was | 103, 199, 234 |
| abstract_inverted_index.MSCs | 44, 53, 95, 261, 267 |
| abstract_inverted_index.OMSC | 102 |
| abstract_inverted_index.UMSC | 144 |
| abstract_inverted_index.aged | 94, 266 |
| abstract_inverted_index.been | 9 |
| abstract_inverted_index.bone | 51 |
| abstract_inverted_index.cell | 27 |
| abstract_inverted_index.cord | 43 |
| abstract_inverted_index.data | 255 |
| abstract_inverted_index.from | 40, 54, 68, 259 |
| abstract_inverted_index.gene | 240 |
| abstract_inverted_index.have | 8, 90 |
| abstract_inverted_index.into | 219 |
| abstract_inverted_index.less | 180 |
| abstract_inverted_index.mice | 171 |
| abstract_inverted_index.more | 183, 200 |
| abstract_inverted_index.p21, | 129 |
| abstract_inverted_index.p53, | 128 |
| abstract_inverted_index.risk | 6 |
| abstract_inverted_index.role | 100 |
| abstract_inverted_index.stem | 17, 26 |
| abstract_inverted_index.such | 126 |
| abstract_inverted_index.than | 137, 208 |
| abstract_inverted_index.that | 89, 241, 257 |
| abstract_inverted_index.they | 186 |
| abstract_inverted_index.used | 74 |
| abstract_inverted_index.vivo | 169 |
| abstract_inverted_index.were | 73, 96, 132, 151, 162, 187 |
| abstract_inverted_index.will | 21 |
| abstract_inverted_index.with | 143, 172, 189, 194, 196 |
| abstract_inverted_index.After | 141 |
| abstract_inverted_index.OMSC. | 197 |
| abstract_inverted_index.OMSCs | 77, 80, 136, 150, 165, 190, 206, 220 |
| abstract_inverted_index.There | 198 |
| abstract_inverted_index.UMSCs | 72, 204 |
| abstract_inverted_index.after | 185 |
| abstract_inverted_index.cells | 18 |
| abstract_inverted_index.could | 46 |
| abstract_inverted_index.found | 114, 235 |
| abstract_inverted_index.human | 41 |
| abstract_inverted_index.mimic | 218 |
| abstract_inverted_index.model | 108 |
| abstract_inverted_index.mouse | 107 |
| abstract_inverted_index.other | 4 |
| abstract_inverted_index.study | 33 |
| abstract_inverted_index.their | 60, 270 |
| abstract_inverted_index.these | 146 |
| abstract_inverted_index.those | 138, 195 |
| abstract_inverted_index.treat | 76 |
| abstract_inverted_index.which | 20 |
| abstract_inverted_index.young | 260 |
| abstract_inverted_index.Apaf1. | 281 |
| abstract_inverted_index.OMSCs. | 210, 228 |
| abstract_inverted_index.UMSCs. | 140 |
| abstract_inverted_index.affect | 22 |
| abstract_inverted_index.better | 177 |
| abstract_inverted_index.effect | 161 |
| abstract_inverted_index.factor | 232 |
| abstract_inverted_index.higher | 134 |
| abstract_inverted_index.impair | 12 |
| abstract_inverted_index.marrow | 52 |
| abstract_inverted_index.medium | 70 |
| abstract_inverted_index.person | 56 |
| abstract_inverted_index.repair | 274 |
| abstract_inverted_index.study, | 170 |
| abstract_inverted_index.tested | 104 |
| abstract_inverted_index.(Apaf1) | 233 |
| abstract_inverted_index.(MSCs), | 19 |
| abstract_inverted_index.(UMSCs) | 45 |
| abstract_inverted_index.cardiac | 63, 173, 178 |
| abstract_inverted_index.derived | 39 |
| abstract_inverted_index.enhance | 47, 269 |
| abstract_inverted_index.factors | 7, 125 |
| abstract_inverted_index.improve | 59, 263 |
| abstract_inverted_index.miR-136 | 201, 213, 217, 246, 278 |
| abstract_inverted_index.repair. | 64 |
| abstract_inverted_index.suggest | 256 |
| abstract_inverted_index.whether | 37 |
| abstract_inverted_index.(OMSCs), | 57 |
| abstract_inverted_index.3’UTR. | 252 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Exosomes | 66 |
| abstract_inverted_index.Methods: | 65 |
| abstract_inverted_index.Results: | 112 |
| abstract_inverted_index.activity | 116 |
| abstract_inverted_index.capacity | 61 |
| abstract_inverted_index.compared | 193 |
| abstract_inverted_index.directly | 248 |
| abstract_inverted_index.efficacy | 24 |
| abstract_inverted_index.exosomal | 277 |
| abstract_inverted_index.exosomes | 38, 88, 258 |
| abstract_inverted_index.function | 271 |
| abstract_inverted_index.generate | 79 |
| abstract_inverted_index.injected | 188 |
| abstract_inverted_index.molecule | 85 |
| abstract_inverted_index.reduced. | 153 |
| abstract_inverted_index.reported | 10 |
| abstract_inverted_index.Apoptotic | 229 |
| abstract_inverted_index.apoptosis | 224 |
| abstract_inverted_index.exosomes, | 145 |
| abstract_inverted_index.extracted | 67 |
| abstract_inverted_index.fibrosis, | 181 |
| abstract_inverted_index.function, | 179 |
| abstract_inverted_index.increased | 163 |
| abstract_inverted_index.mycardiac | 110 |
| abstract_inverted_index.objective | 30 |
| abstract_inverted_index.paracrine | 160 |
| abstract_inverted_index.peptidase | 230 |
| abstract_inverted_index.potential | 91 |
| abstract_inverted_index.regulated | 244 |
| abstract_inverted_index.screened, | 97 |
| abstract_inverted_index.targeting | 249 |
| abstract_inverted_index.treatment | 142 |
| abstract_inverted_index.umbilical | 42 |
| abstract_inverted_index.activating | 231 |
| abstract_inverted_index.activities | 14, 49, 264 |
| abstract_inverted_index.attenuated | 222 |
| abstract_inverted_index.downstream | 239 |
| abstract_inverted_index.expression | 122, 202 |
| abstract_inverted_index.infarction | 174 |
| abstract_inverted_index.migration, | 156 |
| abstract_inverted_index.myocardial | 273 |
| abstract_inverted_index.negatively | 243 |
| abstract_inverted_index.phenotypes | 148 |
| abstract_inverted_index.rejuvenate | 93 |
| abstract_inverted_index.remarkably | 152 |
| abstract_inverted_index.senescence | 147, 226 |
| abstract_inverted_index.Backhround: | 1 |
| abstract_inverted_index.Conclusion: | 253 |
| abstract_inverted_index.conditioned | 69 |
| abstract_inverted_index.investigate | 36 |
| abstract_inverted_index.mesenchymal | 16 |
| abstract_inverted_index.Upregulation | 211 |
| abstract_inverted_index.angiogenesis | 184 |
| abstract_inverted_index.transfection | 215 |
| abstract_inverted_index.transferring | 276 |
| abstract_inverted_index.aging-related | 124 |
| abstract_inverted_index.significantly | 133, 176, 221 |
| abstract_inverted_index.anti-apoptotic | 158 |
| abstract_inverted_index.cardiovascular | 5 |
| abstract_inverted_index.downregulating | 280 |
| abstract_inverted_index.proliferation, | 155 |
| abstract_inverted_index.infarction(MI). | 111 |
| abstract_inverted_index.differentiation, | 157 |
| abstract_inverted_index.transplantation. | 28 |
| abstract_inverted_index.β-galactosidase | 119 |
| abstract_inverted_index.senescence-associated | 118 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.19823851 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |