Expanding the uses of genome‐scale models with protein structures Article Swipe
Nathan Mih
,
Bernhard Ø. Palsson
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15252/msb.20188601
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.15252/msb.20188601
Biology is reaching a convergence point of its historic reductionist and modern holistic approaches to understanding the living system. Structural biology has historically taken the reductionist approach to deeply probe the inner workings of complex molecular machines. In contrast, systems biology and genome-scale modeling have organically grown out of the wealth of data now being generated by diverse omics measurements. In the late 2000s, a proposed interdisciplinary field of structural systems biology pitched the merger of these two approaches, with widespread applications in pharmacology, disease modeling, protein engineering, and evolutionary studies. In this commentary, we highlight the challenges of integrating these two fields, with a focus on genome-scale metabolic modeling, and the novel findings that are made possible from such a merger.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15252/msb.20188601
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/msb.20188601
- OA Status
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- Cited By
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All OpenAlex metadata
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https://doi.org/10.15252/msb.20188601Digital Object Identifier
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Expanding the uses of genome‐scale models with protein structuresWork title
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articleOpenAlex work type
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enPrimary language
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2019Year of publication
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2019-11-01Full publication date if available
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Nathan Mih, Bernhard Ø. PalssonList of authors in order
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https://doi.org/10.15252/msb.20188601Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/msb.20188601Direct link to full text PDF
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goldOpen access status per OpenAlex
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Library science, Biology, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
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2024: 3, 2023: 1, 2021: 2, 2020: 6, 2019: 1Per-year citation counts (last 5 years)
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11Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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