Experimental and Computational Investigation of the Target and Mechanisms of Gelsemium Alkaloids in the Central Nervous System Article Swipe
Yunfan Wang
,
Zhijiang Yang
,
Tengxin Huang
,
Li Pan
,
Junjie Ding
,
Zhao‐Ying Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26031312
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26031312
Gelsemium has a long history of medicinal use but is also a poisonous plant. Some low-toxicity alkaloids in Gelsemium exhibit anxiolytic, anti-inflammatory, analgesic, and other pharmacological effects; however, certain alkaloids in Gelsemium are highly toxic. Nevertheless, the molecular targets underlying the biological effects of Gelsemium alkaloids remain poorly understood. We employed electrophysiological techniques and molecular modeling to examine the modulatory effects of Gelsemium alkaloids on inhibitory neurotransmitter receptors, as well as to elucidate the mechanisms underlying their molecular interactions. Our findings indicate that low-toxicity alkaloids primarily exert their pharmacological effects through actions on glycine receptors, with the binding site located at the orthosteric site between two α-subunits. Both highly toxic and low-toxicity alkaloids target GABAA receptors, using the β+/α− interface transmembrane structural domains as common binding sites. These results identify the targets through which Gelsemium alkaloids affect the central nervous system and predict the binding modes and key amino acids involved from a computational modeling perspective. However, further experimental validation through mutational studies is necessary to strengthen these findings.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms26031312
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4407143863Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms26031312Digital Object Identifier
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Experimental and Computational Investigation of the Target and Mechanisms of Gelsemium Alkaloids in the Central Nervous SystemWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-02-04Full publication date if available
- Authors
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Yunfan Wang, Zhijiang Yang, Tengxin Huang, Li Pan, Junjie Ding, Zhao‐Ying LiuList of authors in order
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https://doi.org/10.3390/ijms26031312Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/ijms26031312Direct OA link when available
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GABAA receptor, Pharmacology, Chemistry, Biology, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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50Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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